DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and Myo9a

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_599162.2	Gene:	Myo9a / 171296	RGDID:	621395	Length:	2626	Species:	Rattus norvegicus

Alignment Length:	229	Identity:	58/229 - (25%)
Similarity:	93/229 - (40%)	Gaps:	2/229 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 HTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYV 383
            |.|....:.....|..|...|........|:.|...||..|....|..|..:.....:....|..
  Rat  2068 HMFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVE 2132

  Fly   384 TDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTDIYV 448
            .....|....:|.::...:|.||..||...|:||.|.|..:.|.|::.......:.:|.:.:|:|
  Rat  2133 LSRLTSEDRAVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHV 2197

  Fly   449 LCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQR 513
            :....|.:||.|..||:....:::|..|:...:.|.....:...:.||.:.:..||..||.|..|
  Rat  2198 IASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLSTLERLIFHLVR 2262

  Fly   514 IA-QCPVVLMPIDNISLIFGPTIVGY-STPDPDQ 545
            || |.....|..:.::::|.|.|:.. .|.||.|
  Rat  2263 IALQEDTNRMSANALAIVFAPCILRCPDTTDPLQ 2296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	11/47 (23%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	46/167 (28%)
Myo9a	NP_599162.2	Actin-binding. /evidence=ECO:0000250	908..919
		Neck or regulatory domain. /evidence=ECO:0000250	1022..1163
		Tail. /evidence=ECO:0000250	1164..2589		58/229 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1276
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1360..1397
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1562..1602
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1618..1673
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1689..1726
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1765..1784
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1872..1907
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2365..2385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2449..2527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2552..2614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910