DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and Arhgap4

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_011245832.1	Gene:	Arhgap4 / 171207	MGIID:	2159577	Length:	965	Species:	Mus musculus

Alignment Length:	783	Identity:	145/783 - (18%)
Similarity:	247/783 - (31%)	Gaps:	267/783 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RMFEQYH-------------EKCAGYAAETARIQNELDKSLTKMGD----LEGKLFHARRIIDME 80
            ::.||.|             ::.|.:....|.::.|..:.|.|:.:    ..|:|..:.:
Mouse    31 QLSEQLHCLELQGELRRDLLQELAEFMRRRAEVELEYSRGLDKLAERFTSRSGRLGGSSQ----- 90

  Fly    81 IKARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLHTLPSSRKRKSLNAVRED----- 140
               .:|:..:...:.|.:...|.||.|.|   .::|:..|....|.....:: |:.:.||
Mouse    91 ---EQQSFRKEPTLLSPLHCWAVLLEHTR---QQSRESAALSEVLAGPLAQR-LSHISEDVGRIV 148

  Fly   141 -KSYGDINSTGS----LLSDLSIT-------HSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKR 193
             ||...:....:    ::|:|..|       |||....:.:..::.|:....          :.|
Mouse   149 KKSKDLVQQLQAELLEVVSELQTTKKMYHVYHSESMNAETKLREAERQEEKR----------SGR 203

  Fly   194 SRLSTGLNGSMSGTTPT----TGKSRRSSVGIG---VEQ-------------------------- 225
            |.|||....|.:.||.|    ||..|:||:..|   ||:
Mouse   204 SALSTTTTTSATTTTTTTTVETGPHRKSSLKKGGRLVEKRQAKYLEHKLKCTKARNEYLLSLASV 268

  Fly   226 ---------HTV-------DVG------QGAERFCATTKVTIPQDGQGVIRAESTIESL------ 262
                     |.:       |.|      |....:.|....|.....||:...|..:|:|
Mouse   269 NAAISNYYLHDILDLMDCCDTGFHLALEQALRSYTAAESRTQTSQMQGLGSLEEALEALDPPGDK 333

  Fly   263 ----------------------------------------------------------------- 262

Mouse   334 AKVLEVHAMAFCPPLRFEYQPHEDDEVAEVLIEMELWDEILPRAQNIQSRLDQKTIETEEVNKTL 398

  Fly   263 ---------PVIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAMAPHVVAESG----TPLQH-- 312
                     .|.:.:..|.|.|.::|....||..::.|.|.......:...|:.    |.||.
Mouse   399 KATLKALLEAVASEDGDILDSLQASPSTESLKSTSSDPGTRQTGRRRNQQQETETFYITKLQEYL 463

  Fly   313 ------RPLMRNHTFSQKTFLRGD------NCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTV 365
                  ..|...|...|:...:|:      :..||.:| :|.      :..|.  |...:|
Mouse   464 SGRSILSKLQAKHEKLQEAIQQGNKEKQETSRTQCTER-KFH------KSHPP--HPRFQY---- 515

  Fly   366 SCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKE 430
                     ..:...|.:..|..|....:|.::..|:..|...||...|::|:|.::.....:::
Mouse   516 ---------NQRLFGGDLEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQARISEIRD 571

  Fly   431 QFLRGKATPHLGNT--DIYVLCCCVKDFLRSLTEPLIPTSQWKD-FANA---VQNPDTKTAQDML 489
            .|.||:.....|.|  |:..:...:|.:.|||..||.|...:.: .|:|   |.....:....:|
Mouse   572 AFERGEDPLEKGCTVHDLDSVAGVLKLYFRSLEPPLFPLDMFNELLASAELEVVGERVEPVSHLL 636

  Fly   490 VKSVKQLPQANRDTLAFLILHFQRIAQ-CPVVLMPIDNISLIFGPTIVGYSTPDP---DQHAIYT 550
            .|    ||:.....|.:|......:|| ....:|...|:::.||||::    |.|   |..|:..
Mouse   637 FK----LPRPVLVVLRYLFTFLNHLAQYSDENMMDSYNLAVCFGPTLL----PVPAGQDPVALQG 693

  Fly   551 EVFTQKQVMKALLELPVSFWEQYIVIDPTRTPATVIKRV---PS----NKNDLLSLYATP---FK 605
            .|   .|:::.|:..|..     |...|...|..:.::.   ||    ....|.||...|   .|
Mouse   694 RV---NQLVQTLILQPAR-----IFPPPAMLPGPIYEKCMAPPSASCLGDGQLESLIGEPELELK 750

  Fly   606 GGT 608
            .||
Mouse   751 TGT 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	10/53 (19%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	49/198 (25%)
Arhgap4	XP_011245832.1	F-BAR_srGAP	30..296	CDD:153340	52/286 (18%)
		RhoGAP	518..705	CDD:383032	48/197 (24%)
		SH3	769..823	CDD:388381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910