Protein Alignment tum and AgaP_AGAP008912

DIOPT Version :9

• Sequence 1: NP_610912.2
• Gene: tum / 36538
• FlyBaseID: FBgn0086356
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: XP_319660.4
• Gene: AgaP_AGAP008912 / 1279880
• VectorBaseID: AGAP008912
• Length: 629
• Species: Anopheles gambiae
• Alignment Length: 676
• Identity: 268/676 - (39%)
• Similarity: 365/676 - (53%)
• Gaps: 104/676 - (15%)

  Fly     1 MALSALASFDDLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKMGD 65
            |.||.:|.||:|||...||.|||.|.|||||:::.::...:......|..|:|.|||.:|..:.:
Mosquito     5 MELSLVAQFDELRRSCDVLLDGTAEVEFLRFVQLQDECRMQWLKSIEEAKRLQRELDNALRSITN 69

  Fly    66 LEGKLFHARRIIDMEIKARRQAEHERDAMESKIMAVADLLRHERNLNNETRDKLAFLHTLPSSRK 130
            ||.||||||::::.|.||||.||||||.||.|:|||.:::|:|:.|.:|||::||...|.|   :
Mosquito    70 LESKLFHARKLLETETKARRHAEHERDTMERKMMAVCEIVRNEQTLRDETREQLAVFATEP---R 131

  Fly   131 RKSLNAVREDKSY----------GDINSTGSLLSDLSITHSEDDFLD----VRTSKSWREHRPSL 181
            |:|.:|..:|:..          .|||||||.|.|||:|.||||||:    ....|||::||||.
Mosquito   132 RRSRHAGHDDREMTGGGGGGGVDNDINSTGSFLVDLSLTQSEDDFLEPLKLQAKRKSWKKHRPSY 196

  Fly   182 PKN---QIPSVGNKR-SRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTK 242
            ..|   ::|....|| ..:|         ||..|.:.|...                 ...|..|
Mosquito   197 NNNASFKMPQEPTKRVMEIS---------TTANTMEPRTEG-----------------EIIAHAK 235

  Fly   243 VTIP--QDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEATAPPLTPVNAMAPHV--V 303
            ||:|  .|| |.|:||||..::               .|:|   :.|........|:.|..|  |
Mosquito   236 VTVPTGPDG-GPIQAESTFRTM---------------APQR---QPAVVTSCASSNSTAATVVNV 281

  Fly   304 AESGTPL----QHRP----LMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCR 360
            ..:.||.    .|.|    :.|.|....:|.:....|.|||:|||||...||||:|....|..||
Mosquito   282 PTAATPTAPEKHHEPMRTVIQRQHDLVSRTLISSVTCNQCQQRIRFGNSSLRCRECKAMFHAYCR 346

  Fly   361 YLLTVSCVPQTGTPTTKTMTGYVT---DFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSE 422
            ..::..||||  :.|.....|.::   |:.||.:|.|||||||||:|||.||||||||||||.||
Mosquito   347 EKISFPCVPQ--SQTKNGPAGAISCLDDYCPSSSPRIPALIVHCVSEIENRGLTEVGLYRLSGSE 409

  Fly   423 REYKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDT----K 483
            ||.:||||:||.||..|.||..|:.|||.|:|||||:|.|||||.:...:|::||....:    :
Mosquito   410 REVRALKEKFLHGKTIPTLGQIDVNVLCSCIKDFLRTLREPLIPNALLGEFSSAVSGATSPNGGQ 474

  Fly   484 TAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQCPVVLMPIDNISLIFGPTIVGYSTPDPDQHAI 548
            ..:..|.:.:::||..||||||||:|||||:||.....|||||::.:|.||||||:..|.|.:.:
Mosquito   475 RMRQQLCQLIERLPAPNRDTLAFLMLHFQRVAQSEAAKMPIDNLARVFAPTIVGYTRADLDMNEM 539

  Fly   549 YTEVFTQKQVMKALLELPVSFWEQYIVIDP--------TRTPATVIKRVPSNKNDLL--SL---- 599
            ..|.:.|..:::|:|.:...:|.|:|::.|        :...|...:|  ....||:  ||
Mosquito   540 CAETYVQFSIVQAMLHISTDYWSQFIMLQPVDQGGDGGSNMGAPTPRR--GGAGDLMMQSLSKDR 602

  Fly   600 -YATPFKGGTIKKRKFYGTPPASAHK 624
             ..||......|.||:|.|||....|
Mosquito   603 RMETPILRRPRKDRKYYATPPYKTSK 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	19/47 (40%)
		RhoGAP_MgcRacGAP	381..570	CDD:239847	99/195 (51%)
AgaP_AGAP008912	XP_319660.4	C1	305..353	CDD:197519	19/47 (40%)
		RhoGAP_MgcRacGAP	365..561	CDD:239847	99/195 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	172	1.000	Domainoid score	I7713
eggNOG	1	0.900	-	-		E1_KOG3564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8077
Inparanoid	1	1.050	415	1.000	Inparanoid score	I3815
OMA	1	1.010	-	-		QHG49807
OrthoDB	1	1.010	-	-		D184774at33208
OrthoFinder	1	1.000	-	-		FOG0004815
OrthoInspector	1	1.000	-	-		oto108302
Panther	1	1.100	-	-	LDO	PTHR46199
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3396
TreeFam	1	0.960	-	-
	13	12.940