DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and AgaP_AGAP003944

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_318402.5	Gene:	AgaP_AGAP003944 / 1278773	VectorBaseID:	AGAP003944	Length:	1908	Species:	Anopheles gambiae

Alignment Length:	627	Identity:	144/627 - (22%)
Similarity:	223/627 - (35%)	Gaps:	165/627 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 TARIQNELDKSLT----------KMGDLEGKLFHARRIIDMEIKARRQAEHE---RDAMESKIMA 100
            |.|:|:|.|.:::          .:.||..::..:..|...:       |:.   |.|..|.  |
Mosquito   551 TDRLQDEADGNVSAPEYSLPIRRDIRDLRNRITASPSIFTSD-------EYRAWLRRAPSSS--A 606

  Fly   101 VADLLRHERNLNNETRDKLAFLHTLPSS--------RKRKSLNAVREDKSYGDINSTGSLLSDLS 157
            :.:.:|..|:|.|:.|     .|....|        :..:.:.:.|.....|...:.|.::....
Mosquito   607 ICEQMRASRDLLNQQR-----AHRFSCSAENIHDVLKNTEHIYSSRTGLGMGGAGAGGGVVGGTL 666

  Fly   158 ITHS------EDDFLDVRT-------------SKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGS 203
            ..||      ....|.||:             |.|.|..|..|...|...||.....:...|.|.
Mosquito   667 DRHSMAAGGPRMSSLPVRSLSSQHIGGPSSIRSPSVRRMRQLLELTQGAGVGGVPGSVVAALTGH 731

  Fly   204 MS-GTTPTTGKSR-RSSVGIGVEQHT--------VD-------------VGQGAERFCATTKVTI 245
            .| ..||:|...| ...:.|...::|        ||             .|:|......|:::..
Mosquito   732 QSPAPTPSTTLPRAHRQIDINPAEYTKYKLDKPVVDAVGMSGMLWIHLLAGRGLRAMSETSQIQQ 796

  Fly   246 P--QDGQGVIRAESTIESLPVIAGNERIGD-----------GLSSTPRRSVLKEATAPPLTPVNA 297
            |  :|...|:..:...::..|:    |.||           .|....:..||..:..|
Mosquito   797 PLIRDLYCVLECDRIHKARTVV----RSGDLQFDWDESFELDLVCNKQLDVLVYSWDP------- 850

  Fly   298 MAPHVVAESGTPLQHR-PLMRNHTFSQKTFLRGDNCVQCQKRIR-FGAVGLRCRDCPVRCHIDCR 360
                         ||| .|......|..|.||.....|...::. .|.:.||.|      |.|..
Mosquito   851 -------------QHRHKLCYRGALSLTTLLRQSPIHQLALKVEPRGTIYLRLR------HTDPF 896

  Fly   361 YLLTVSCVPQTGTPTTK------------TMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEV 413
            .|..     :.|.|:.:            |:....:..||..|| :|.::..||.|:|.|||..:
Mosquito   897 QLFR-----RRGLPSLRGNVPALFGADLETVVTRESKGAPGCAP-VPIILRRCVEEVERRGLDII 955

  Fly   414 GLYRLSSSEREYKALKEQFLRG----KATP-HLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDF 473
            |||||..|..:.:.|:|.|.|.    :.|| |:  .||.|:...:||:||.|.|||.....::..
Mosquito   956 GLYRLCGSATKKRLLREAFERNSRAVELTPEHV--PDINVITGVLKDYLRELPEPLFTKCLFQMT 1018

  Fly   474 ANA--VQNPDTKTAQDMLVKSVKQ-LPQANRDTLAFLILHFQRIAQCPV-VLMPIDNISLIFGPT 534
            .:|  |..||.......|:.|:.. ||:|||.||.||:.|...:..... ..|....::...||.
Mosquito  1019 VDALGVCLPDDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSAAERNKMSAQALATALGPP 1083

  Fly   535 IVGYSTP----DPDQHAIYTEVFTQKQVMKALLELPVSFWEQ 572
            ::.:|..    :...||      ....|:|.||::    |.|
Mosquito  1084 LMLHSASVGANEEIDHA------QPIAVLKYLLQI----WPQ 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	12/48 (25%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	62/201 (31%)
AgaP_AGAP003944	XP_318402.5	PDZ_signaling	140..223	CDD:238492
		C2	775..874	CDD:175973	22/122 (18%)
		RhoGAP	915..1114	CDD:295372	63/211 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910