DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and Arhgap5

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_033836.2	Gene:	Arhgap5 / 11855	MGIID:	1332637	Length:	1503	Species:	Mus musculus

Alignment Length:	513	Identity:	107/513 - (20%)
Similarity:	185/513 - (36%)	Gaps:	139/513 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 RNLNNET-RDKLAFLHTLPSSRKR-KSLNAVREDKSYGD--------------------INSTGS 151
            :|...:| |..||....:.||... :.|:.:.:.|.|.|                    :|:|..
Mouse  1068 KNPRKQTSRVPLAHPEDMDSSDNYVEPLDTIFKQKGYSDEIYVVPDDSQNRIIKIRNSFVNNTQG 1132

  Fly   152 LLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTGLNGSMSGTTP-TTGKSR 215
                    ..|:.|.| ||||...|.|||..|.:..::.:|........:...|.... ||.|::
Mouse  1133 --------DEENGFSD-RTSKGHGERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFTTSKTK 1188

  Fly   216 RSSVGIGVEQHTVDVGQGAERFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPR 280
            |..      :|     :|:|.....:.|...:.|         |:: |.|..::.:.|
Mouse  1189 RKG------RH-----RGSEEDPLLSPVETWKGG---------IDN-PAITSDQEVDD------- 1225

  Fly   281 RSVLKEATAPPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVG 345
             ..:|:.|            |.|.|.          :......|||
Mouse  1226 -KKIKKKT------------HKVKED----------KKQKKKTKTF------------------- 1248

  Fly   346 LRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGL 410
                :.|.|.:.:..|.         |.|        :.|...:..| ||..:..||..||..||
Mouse  1249 ----NPPTRRNWESNYF---------GMP--------LQDLVTAEKP-IPLFVEKCVEFIEDTGL 1291

  Fly   411 TEVGLYRLSSSEREYKALKEQFLRGKATPHLGNTDIYV--LCCCVKDFLRSLTEPLIPTSQWKDF 473
            ...||||:|.::.:...:::||.:.. ..:|.:.::.|  :...:|.|...|.:||||.|...:.
Mouse  1292 CTEGLYRVSGNKTDQDNIQKQFDQDH-NINLASMEVTVNAVAGALKAFFADLPDPLIPYSLHPEL 1355

  Fly   474 ANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIA-QCPVVLMPIDNISLIFGPTIVG 537
            ..|.:.||.......|.:.||:....|.|...::|.|..|:: |..:.||..||:|:.|.||::
Mouse  1356 LEAAKIPDKTERFHALKEIVKKFHPVNYDVFRYVITHLNRVSQQNKINLMTADNLSICFWPTLM- 1419

  Fly   538 YSTPDPDQHAIYTEVFTQKQVMKALLELPVSFWEQYIVID--------PTRTPATVIK 587
              .||.:.....:.....:.|::..::....|:....:::        ||..|..:::
Mouse  1420 --RPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGEIVETANTVAPPPTSNPGQLVE 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	6/47 (13%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	50/191 (26%)
Arhgap5	NP_033836.2	P-loop_NTPase	31..246	CDD:393306
		RhoGAP-FF1	260..338	CDD:374593
		FF	368..420	CDD:128718
		FF	428..481	CDD:128718
		FF	484..533	CDD:128718
		RhoGAP_p190	1261..1445	CDD:239838	52/205 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910