DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and RALBP1

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_006779.1	Gene:	RALBP1 / 10928	HGNCID:	9841	Length:	655	Species:	Homo sapiens

Alignment Length:	258	Identity:	68/258 - (26%)
Similarity:	111/258 - (43%)	Gaps:	34/258 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 VPQTGTPTTKTMTGYVTDFAPSIAPM-----IPALIVHCVNEIEARGLTEVGLYRLSSSEREYKA 427
            |||...|..|.:.|.....|.....|     :||:...|::.:|..|:...|:||:|..:.:...
Human   178 VPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDE 242

  Fly   428 LKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAV-QNPDTKTAQDMLVK 491
            ||..:.|.::| :|.:.:...:...:|.:||.|.|.|:.......|..|. :..:|:..|: ..:
Human   243 LKAAYDREEST-NLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQE-FQR 305

  Fly   492 SVKQLPQANRDTLAFLILHFQR-IAQCPVVLMPIDNISLIFGPTIVGYSTPDPDQHAIYT----- 550
            .:|:||:.|...:::||:|... ||:.....|.|.|||::..||:      ......:|.
Human   306 LLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTV------QISNRVLYVFFTHV 364

  Fly   551 -EVF---TQKQVMKALLELPVSFWEQYIVIDPTRTPATV--IKRVPSNKNDLLSLYATPFKGG 607
             |:|   ..|||||.|.      |.....: || .|.|.  ||.....:..||:......:||
Human   365 QELFGNVVLKQVMKPLR------WSNMATM-PT-LPETQAGIKEEIRRQEFLLNCLHRDLQGG 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	52/204 (25%)
RALBP1	NP_006779.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..158
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9PT60	102..119
		Mediates association with membranes and could form transmembrane domains. /evidence=ECO:0000269\|PubMed:15610018	154..219		11/40 (28%)
		RhoGap_RalBP1	190..371	CDD:239846	46/188 (24%)
		SMC_N	<400..>627	CDD:330553	4/20 (20%)
		Mediates interaction with RALA and RALB. /evidence=ECO:0000269\|PubMed:20696399, ECO:0000269\|PubMed:7673236	403..499		4/17 (24%)
		Mediates interaction with REPS1 and REPS2. /evidence=ECO:0000250\|UniProtKB:Q62796	500..655
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..551
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910