DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tum and DLC1

DIOPT Version :9

Sequence 1:NP_610912.2 Gene:tum / 36538 FlyBaseID:FBgn0086356 Length:625 Species:Drosophila melanogaster
Sequence 2:NP_001335010.1 Gene:DLC1 / 10395 HGNCID:2897 Length:1528 Species:Homo sapiens


Alignment Length:454 Identity:92/454 - (20%)
Similarity:153/454 - (33%) Gaps:121/454 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 RKRKSLNAVREDKSYGDINSTGSLL----SDLSITHSEDDFLDV-----------RTSKSWREH- 177
            ::|.|.:::....|..| |..||:|    .||:...:||.|.::           |....|.|. 
Human   864 KRRNSSSSMSSRLSIYD-NVPGSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEKF 927

  Fly   178 ---------------RPSLPKNQIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHT 227
                           .||.||.....|.|.|             |||:...|..:|:....|...
Human   928 SDEGDSDSALDSVSPCPSSPKQIHLDVDNDR-------------TTPSDLDSTGNSLNEPEEPSE 979

  Fly   228 V----DVGQGAERFCATTKVTIPQDGQGVIRAESTIESLPVIAGNERIGDGLSSTPRRSVLKEAT 288
            :    |.|.||         ::.:..:..:|..|...|......:..:.....|..:.::|::.:
Human   980 IPERRDSGVGA---------SLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYS 1035

  Fly   289 APPLTPVNAMAPHVVAESGTPLQHRPLMRNHTFSQKT--FLRGDNCVQCQKRIRFGAVGLRCRDC 351
            ...||        .:.|..||      ...|.||...  |::.......:.|..||..       
Human  1036 LLKLT--------ALLEKYTP------SNKHGFSWAVPKFMKRIKVPDYKDRSVFGVP------- 1079

  Fly   352 PVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLY 416
                       |||: |.:||.|..:           ||...:..|..||        |.:|||:
Human  1080 -----------LTVN-VQRTGQPLPQ-----------SIQQAMRYLRNHC--------LDQVGLF 1113

  Fly   417 RLSSSEREYKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPD 481
            |.|..:...:||::.........:......|.:...:|.:.|.|.|||:.....:.|....|   
Human  1114 RKSGVKSRIQALRQMNEGAIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQ--- 1175

  Fly   482 TKTAQDMLVKSVKQ----LPQANRDTLAFLILHFQRI-AQCPVVLMPIDNISLIFGPTIVGYST 540
             ...:|..::::|.    ||..||:.|..|:.....: |......|...|:::...|::...:|
Human  1176 -YVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFHLNT 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tumNP_610912.2 C1 319..367 CDD:237996 10/49 (20%)
RhoGAP_MgcRacGAP 381..570 CDD:239847 35/165 (21%)
DLC1NP_001335010.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..94
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..310
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..436
SAM_DLC1 454..513 CDD:188990
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 558..617
Focal adhesion-targeting (FAT) 710..884 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..764
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 829..876 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 928..990 15/74 (20%)
Polybasic cluster (PBR) 1051..1073 4/21 (19%)
RhoGAP_DLC1 1072..1290 CDD:239840 45/209 (22%)
START_STARD12-like 1315..1518 CDD:176917
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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