DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and arhgap44b

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_021336115.1	Gene:	arhgap44b / 100333556	ZFINID:	ZDB-GENE-120206-2	Length:	862	Species:	Danio rerio

Alignment Length:	511	Identity:	95/511 - (18%)
Similarity:	178/511 - (34%)	Gaps:	152/511 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 MEIKARRQAEHERDAMESKIMAVADLLRHERNL------NNETRDKLAFL-----------HTLP 126
            ::|.:||:.....:|.:::::: .|||:.|:.|      ::.|..||:..           .::.
Zfish     8 LQISSRRKRRAPPEAEKTEVLS-DDLLQVEKRLELVKQVSHSTHKKLSACLQGQQCVEVDKRSVR 71

  Fly   127 SSRKRKSLNAVREDKSYGDINSTGSLLSD-------LSITHSEDDFL-------DVRTSKSWREH 177
            |..|:..|.::.:....|     .::|.|       |.|.....|.|       :::..:...|.
Zfish    72 SPSKKLPLTSLAQCLVEG-----AAVLGDDCLLGKMLKICGEAQDSLAQELLLFELQIERDVVEP 131

  Fly   178 RPSLPKNQIPSVGNKRSRLSTGLNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVGQGAERFCATTK 242
            ..:|.:.:||::..:|..|:. |...|........:|.:||.....|..|     ||
Zfish   132 LYTLSEVEIPNIQKQRKHLAK-LVLDMDSARTRWHQSSKSSTLSNKETPT-----GA-------- 182

  Fly   243 VTIPQDGQGVIRAESTIESLPVIAGNERI-GDGLSSTPRRSVLKEAT----------------AP 290
                       :|::..|.:...|....| .|.||:.....|.||..                ..
Zfish   183 -----------KADALREEMEEAANRMEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRK 236

  Fly   291 PLTPVNAMAPHVVAESGT----PLQHRPLMRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDC 351
            .|..:.::.|.:.|:..:    |...:||..:.|.|             .:.|.|
Zfish   237 SLELLQSVLPQIKAQQESWVEKPCYGKPLEEHLTLS-------------GREIAF---------- 278

  Fly   352 PVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLY 416
            |:.           :||                           .:::.|       ||.|.||:
Zfish   279 PIE-----------ACV---------------------------TMLLDC-------GLQEEGLF 298

  Fly   417 RLSSSEREYKALKEQFLRGKATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPD 481
            |::.|..:.|.||.....|.......:.|.:.:...:|.:||.|.|||:....::|:..|....|
Zfish   299 RVAPSASKLKKLKASLDCGVLDYQEYSADPHAIAGALKSYLRELPEPLLTFDLYEDWIQASNIAD 363

  Fly   482 TKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQCPVV-LMPIDNISLIFGPTIV 536
            .......|:.:.::||.||.:...:||....::.:.... .|...||:::.||.::
Zfish   364 QDKRLQALLSTCEKLPVANSNNFKYLIKFLAKMNEYQEYNKMTPGNIAIVLGPNLL 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	5/47 (11%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	35/157 (22%)
arhgap44b	XP_021336115.1	BAR	22..268	CDD:325158	50/276 (18%)
arhgap44b	XP_021336115.1	RhoGAP	257..457	CDD:295372	45/231 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910