DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and LOC100332329

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_009294229.1	Gene:	LOC100332329 / 100332329	-ID:	-	Length:	2281	Species:	Danio rerio

Alignment Length:	716	Identity:	144/716 - (20%)
Similarity:	260/716 - (36%)	Gaps:	166/716 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SALA-----SFDDLRRCMQVLTDGTPEEEFLRFLRMFEQYHEKCAGYAAETARIQNELDKSLTKM 63
            ||:|     |.::..:..:.|...|..|..:...|..|..:.|    ..:...|...||......
Zfish  1411 SAIASQSGISKEEASKKKEPLRSNTQPENLIAGPRSLEDKNIK----TLQNRGISMSLDDVSKIG 1471

  Fly    64 GDLEGKLFHARR-----------IIDMEIKARRQAEHERDAMESKIMAVADLLRH-------ERN 110
            |..:||....|:           ::.:|::         ||....:::::.|...       :|.
Zfish  1472 GSSQGKARQRRKQRLALARICLPVLSLEME---------DAEYIPLVSLSPLETRSTTEAGPDRL 1527

  Fly   111 LNNETRDKLAFLHTL-------PSSRKR----------KSLNAVREDKSYGDINSTGSLLS---- 154
            ..|..::|:...|:|       ||:.:|          |..:...:....||: |..|:|.
Zfish  1528 KANTLKEKVHDTHSLQDASPAQPSTPERTTGFFRKILKKRPHKEAQTPEDGDV-SLASILDHKEA 1591

  Fly   155 --------------------DLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRSRLSTG 199
                                .:.|:||.:     |.|:.|   ..||  |::.:..|:...|...
Zfish  1592 ISPTRSHNSKPQSGRPGRTPSIMISHSTN-----RASEQW---NASL--NRVITNANELRHLDEF 1646

  Fly   200 LNGSMSGTTPTTGKSRRSSVGIGVEQHTVDVG-QGAERFCATTKVTIPQDGQGVIRAESTIESLP 263
            |...::..     :||...:. |.||..::.. |..|.......::.||.|...: ..|....:.
Zfish  1647 LGNQVNDL-----RSRGKQLS-GTEQIFINATMQFRENIKGMYSISKPQIGYKAL-MNSYQNKVI 1704

  Fly   264 VIAGNERIGDGLSSTPR-------------RSVLKEATAPPLTPVNAMAPHVVAESGTPLQHRPL 315
            ::|..::.|:    .|.             |:.:|:..|.|..|....  .:..:.|..|::
Zfish  1705 ILATEKQKGE----VPLVVNLFQSVLDIFIRAEIKKEEAEPAKPPKGR--KMRKKKGKGLEN--- 1760

  Fly   316 MRNHTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCH--------IDCRYLLTVSCVPQTG 372
            ..:|.|:........:|.||...|........|..|.:.||        .||....:..|..:.|
Zfish  1761 ALDHVFTHYQVNIMQSCDQCTSYIWGMEKAYMCSYCKMVCHKKCICKIVTDCSTFSSKKCEDEPG 1825

  Fly   373 TPTTKTMTG-YVTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGK 436
            :.......| .|.:..|     :|.::...:..:|..||...|:||.|.|....|.|.:....|.
Zfish  1826 SNHFGVRVGNLVNNKTP-----VPIVLEIMLEHVEMNGLYTEGIYRKSGSANRMKELHQLLEAGP 1885

  Fly   437 ATPHLGNTDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANR 501
            ....|.:..|:.:...||.:||.|.|||:..:.:.||..|::.|:.:.....:.:.::|||.||.
Zfish  1886 ENVCLEDYPIHAVTGLVKQWLRELPEPLMTFTHYNDFLYAIELPEKQEQLQAIYRVLEQLPTANF 1950

  Fly   502 DTLAFLILHFQRIAQ-------CPVVLMPIDNISLIFGPTIVGY-STPDPDQHAIYTEVFTQKQV 558
            :||..||.|..|:|:       .|      ::::::|.|.|:.. .:.||        :.:.|.|
Zfish  1951 NTLERLIFHLVRVAKEEKSNRMTP------NSLAIVFAPCILRCPDSADP--------LMSMKDV 2001

  Fly   559 MKA-------LLELPVSFWEQYIVIDPTR-TPATVIKRVP-SNKNDLLSL---YATPFKGGTIKK 611
            .|.       |:|....:.|:...|:... ..|..:.::. ..||....|   :.||:|...|::
Zfish  2002 AKTTTCVEMLLIEQIRRYNEKMEEIEQLEYAEALAVNQLKLKRKNTCWHLPLRFITPYKEVAIRE 2066

  Fly   612 R 612
            :
Zfish  2067 K 2067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	12/55 (22%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	52/204 (25%)
LOC100332329	XP_009294229.1	UBQ	13..111	CDD:294102
		MYSc	140..969	CDD:214580
		MYSc_Myo9	160..964	CDD:276836
		DUF4887	1082..1249	CDD:292845
		Stathmin	<1082..1159	CDD:279209
		C1	1764..1812	CDD:237996	10/47 (21%)
		RhoGAP_myosin_IXB	1829..2014	CDD:239872	51/203 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910