DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tum and arhgap21

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_031759009.1	Gene:	arhgap21 / 100037846	XenbaseID:	XB-GENE-1011028	Length:	1952	Species:	Xenopus tropicalis

Alignment Length:	557	Identity:	110/557 - (19%)
Similarity:	189/557 - (33%)	Gaps:	158/557 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RRQAEHERDAMESKIMAVADLLRHERNLNNETRD-----KLAF-----------LHTLPSSRKRK 132
            ||...|:.|::...|:.|.......::.:....|     ||:.           ...:|||...:
Frog   860 RRHFSHDHDSIRPSILEVNSKTERSKSCDEGLDDYKDEGKLSLKQGSSLKGIKARENVPSSEDSE 924

  Fly   133 SLNAVREDKS---YGDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKNQIPSVGNKRS 194
            |    |:|.|   :.|.|..|.|.           |..:.|.|..|......|..|:..|
Frog   925 S----RKDSSSDVFSDSNKEGFLY-----------FRQLTTEKGKRVSGSMRPWKQMYVV----- 969

  Fly   195 RLSTGLNGSMSGTTPTTGKSRRSSVG-----------IGVEQHTVDVGQGAER----FCATTKVT 244
                     :.|:.....|.::...|           ||:....:|:.....:    |..||
Frog   970 ---------LRGSALYLQKDKKEQSGHSSAQSDEEQLIGINGCLIDISYSETKRKNVFRLTT--- 1022

  Fly   245 IPQDGQGVIRAESTIESL---PVIAGNERIGDG--------------------LSSTPRRSVLKE 286
              .|.:.:.:||...:.|   ..|..|..:.|.                    :||:..:|  ::
Frog  1023 --SDREFLFQAEDRDDMLAWIKAIQENGNLNDEQTDQASRVLISKRIKEYNTMMSSSSNKS--EQ 1083

  Fly   287 ATAPPLTPVNAMAPHVVAESGTPLQ--HRPLMRNHTFSQKTFLRGDNCVQCQK----RI------ 339
            :..|....::...|....:....||  |.|...:   .::.|.:.|......|    ||
Frog  1084 SPKPSRQTLSIRQPFRATKPEGKLQSPHSPKQES---ERRLFSKDDISPPKDKGSWRRIMKKPFE 1145

  Fly   340 ----RFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGYVTDFAPSIAPMIPALIVH 400
                ..|..|:|..||| ..| :.:|                                :|.::..
Frog  1146 KKPTTGGTFGVRLDDCP-PAH-NNKY--------------------------------VPLIVDV 1176

  Fly   401 CVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLGN---TDIYVLCCCVKDFLRSLTE 462
            |...:|.|||...|:||:..:.....:::|:..:|.....:.:   .|:.|:...:|.|.|.|.:
Frog  1177 CCKLVEDRGLETTGIYRVPGNNAAISSMQEELNKGSTDIDIQDDKWRDLNVISSLLKSFFRKLPD 1241

  Fly   463 PLIPTSQWKDFANAVQNPDTKTAQDMLVKSVKQLPQANRDTLAFLILHFQRIAQ-CPVVLMPIDN 526
            ||....::.||..|.:..|.......|.:.:..||..:.:||.:|..|.:.:|: .....|...|
Frog  1242 PLFTNEKYNDFIEANRTEDPVERLKTLKRLILDLPDHHYETLKYLSAHLKAVAENSEKNKMEPRN 1306

  Fly   527 ISLIFGPTIVGYS--------TPDPDQHAIYTEVFTQ 555
            ::::||||:|..|        |..|||:.|...:..|
Frog  1307 LAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQQ 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	13/61 (21%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	45/187 (24%)
arhgap21	XP_031759009.1	PDZ_signaling	55..165	CDD:238492
		PH_ARHGAP21-like	938..1051	CDD:269955	25/142 (18%)
		RhoGAP_ARHGAP21	1153..1348	CDD:239860	52/225 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910