DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tum and arhgap35a

DIOPT Version :9

Sequence 1:	NP_610912.2	Gene:	tum / 36538	FlyBaseID:	FBgn0086356	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_001343636.1	Gene:	arhgap35a / 100004299	ZFINID:	ZDB-GENE-120516-2	Length:	1536	Species:	Danio rerio

Alignment Length:	690	Identity:	136/690 - (19%)
Similarity:	240/690 - (34%)	Gaps:	183/690 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LRMFEQYHEKCAGYAA------ET-----ARIQNELDKSLTKMGDLEGKLFHARRIIDMEIKARR 85
            ||.....|...|.|:|      ||     ..:|:.:...|..:.:.:.:|..:..:.| ::....
Zfish   865 LRKSRLVHGYIAVYSAKRKASMETLCAFLCEVQDIIPVQLLAVAETQSELADSEAVRD-QLAQGE 928

  Fly    86 QAEHERDAMESKIM-----AVADLLR--HERNLNNETRDKLAFLHTLPSSRKRKSLNAVREDKSY 143
            :..||.||..|.::     .|..|.|  |.:....|..:|...:..      ....:.|.|:.:.
Zfish   929 ELAHEIDARFSSVICGPGGVVGGLHRIDHFQPFFKEVVEKKTIVEA------THMYDNVAENVTN 987

  Fly   144 GDINSTGSLLSDLSITHSEDDFLDVRTSKSWREHRPSLPKN-----------QIPSV-GNKRSRL 196
            .:::|.......:::..||||.          |..|..|.:           ::|.: |:..|.:
Zfish   988 ENVSSPRCSSPSITLLDSEDDI----------EPSPPYPTSRNDDTLTRGGFKLPDLEGDSYSLI 1042

  Fly   197 S--TGLNGSMSGTTPTT--------------------------GKSRRSSVGIGVEQHTVDVGQG 233
            |  |.|...::...|..                          |.:|||...:...:...|....
Zfish  1043 SEITNLENKINNKVPPQVRPKPNVTFDIPKTQNSSLYTDLALHGSNRRSLPSVTWPEAGYDPSDY 1107

  Fly   234 AERFCATTK---------VTIPQDG-QG---VIRAESTIESLPVIAGNERIGDGLSSTPRRSVLK 285
            ||...|..|         .::|.|. ||   .||..:...|.....|::...|..|...||.:..
Zfish  1108 AEPMDAVAKPRPTEEENIYSVPHDSTQGKIITIRNANKSHSNGAGNGSDSEADSSSLERRRKLSA 1172

  Fly   286 EATAPPL---------------------------TPVNAMAPHVVAESG-TPLQHR---PLMRN- 318
            ....|.|                           || .|....:.|:.| |.|...   |..||
Zfish  1173 LGVKPRLYRDRSKRLGKFSSFRTSFIGSDDELGGTP-KAKEDELGAQKGDTSLNEEGEDPKKRNI 1236

  Fly   319 -HTFSQKTFLRGDNCVQCQKRIRFGAVGLRCRDCPVRCHIDCRYLLTVSCVPQTGTPTTKTMTGY 382
             .:..::|          .|:.|     .:.|...:....:..|.         |.|    :...
Zfish  1237 LRSLGRRT----------TKKTR-----PKARQTSLSKPPESNYF---------GVP----LANV 1273

  Fly   383 VTDFAPSIAPMIPALIVHCVNEIEARGLTEVGLYRLSSSEREYKALKEQFLRGKATPHLG----N 443
            ||...|     ||..|..|::.||..||:..|:||:|.::.|.::::.||   ...|::.    :
Zfish  1274 VTPERP-----IPLFIEKCIHYIETTGLSTEGIYRVSGNKAEMESMQRQF---DQDPNIDLVEKD 1330

  Fly   444 TDIYVLCCCVKDFLRSLTEPLIPTSQWKDFANAVQNPDTK----TAQDMLVKSVKQLPQANRDTL 504
            ..:..:...:|.|...|.:||:|.|...:...|.:..|.:    |.:|:|    ::.|:.|.|..
Zfish  1331 MSVNTVAGALKSFFSELPDPLVPYSMQVELVEAFKINDREHRLHTMKDVL----RRFPRENYDVF 1391

  Fly   505 AFLILHFQRIA-QCPVVLMPIDNISLIFGPTIVGYSTPDPDQHAIYTEVFTQKQVMKALL-ELPV 567
            .::|.|..::: ...:.||..:|:|:.|.||::   .||.......|...|.:.:::..: :...
Zfish  1392 KYVITHLNKVSLNSRLNLMTSENLSICFWPTLM---RPDFTTMDALTATRTYQTIIETFIHQCAF 1453

  Fly   568 SFWEQYIVIDPTRTPATVIKRVPSNKNDLL---SLYATPF 604
            .|:.|.....|:..|..     |::....|   |.|:|.:
Zfish  1454 FFYNQPFADTPSGLPGQ-----PASPTATLSSGSAYSTSY 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tum	NP_610912.2	C1	319..367	CDD:237996	5/47 (11%)
tum	NP_610912.2	RhoGAP_MgcRacGAP	381..570	CDD:239847	47/198 (24%)
arhgap35a	XP_001343636.1	RAB	29..247	CDD:197555
		Ras_like_GTPase	29..245	CDD:206648
		RhoGAP-FF1	261..340	CDD:293121
		FF	431..482	CDD:128718
		RhoGAP_p190	1266..1450	CDD:239838	49/211 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910