Protein Alignment CG6553 and LRP1B

DIOPT Version :10

• Sequence 1: NP_610911.1
• Gene: CG6553 / 36537
• FlyBaseID: FBgn0033880
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_061027.2
• Gene: LRP1B / 53353
• HGNCID: 6693
• Length: 4599
• Species: Homo sapiens
• Alignment Length: 169
• Identity: 54/169 - (31%)
• Similarity: 69/169 - (40%)
• Gaps: 38/169 - (22%)

  Fly    21 TICLG---------------SQNATSC--------GHRCGGGD-------CIQLDQLCDGSANCL 55
            |:||.               .:|.|:|        .|.|..|:       |||....|||..:||
Human   807 TLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCL 871

  Fly    56 DGSDETVAMCEKVWCPGYAFRCSYGACIASTAVCDGVQDCVDGSDEQGWLCRAQMQQANCDNWEM 120
            |||||....|....||...|:|....||....:|||..||....||....|.|:    .|...:.
Human   872 DGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTAR----TCQVDQF 932

  Fly   121 YCSSGQCMTYSKLCDGIRDCRDGDDELES----LCEGVT 155
            .|.:|:|:..:.|||...||.|..||:.|    .||.:|
Human   933 SCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLT 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6553	NP_610911.1	LDLa	34..60	CDD:197566	14/32 (44%)
		LDLa	70..101	CDD:197566	11/30 (37%)
		LDLa	115..146	CDD:197566	10/30 (33%)
LRP1B	NP_061027.2	LDLa	76..109	CDD:197566
		FXa_inhibition	163..193	CDD:464251
		NHL	282..459	CDD:302697
		NHL repeat	285..321	CDD:271320
		LDL-receptor class B 1	295..337
		LY	319..361	CDD:214531
		NHL repeat	328..367	CDD:271320
		LDL-receptor class B 2	338..381
		NHL repeat	371..406	CDD:271320
		LDL-receptor class B 3	382..425
		NHL repeat	415..445	CDD:271320
		FXa_inhibition	475..516	CDD:464251
		LY	548..590	CDD:214531
		LDL-receptor class B 4	568..610
		LY	591..630	CDD:214531
		LDL-receptor class B 5	611..656
		LY	637..686	CDD:214531
		LDL-receptor class B 6	657..706
		LY	687..729	CDD:214531
		LDL-receptor class B 7	707..750
		FXa_inhibition	798..833	CDD:464251	5/25 (20%)
		LDLa	886..919	CDD:238060	13/32 (41%)
		LDLa	926..958	CDD:197566	10/31 (32%)
		LDLa	1006..1038	CDD:238060
		LDLa	1053..1088	CDD:238060
		LDLa	1097..1131	CDD:238060
		LDLa	1136..1169	CDD:197566
		FXa_inhibition	1176..1212	CDD:464251
		YncE	1282..1506	CDD:442618
		LDL-receptor class B 8	1300..1346
		LY	1327..1367	CDD:214531
		LDL-receptor class B 9	1347..1389
		LY	1371..1414	CDD:214531
		LDL-receptor class B 10	1390..1436
		LDL-receptor class B 11	1437..1480
		LDL-receptor class B 12	1481..1522
		LDL-receptor class B 13	1618..1660
		Ldl_recept_b	1618..1658	CDD:459654
		LY	1641..1683	CDD:214531
		LDL-receptor class B 14	1661..1704
		LDL-receptor class B 15	1705..1744
		Ldl_recept_b	1705..1742	CDD:459654
		LY	<1735..1766	CDD:214531
		LDL-receptor class B 16	1745..1787
		FXa_inhibition	1838..1874	CDD:464251
		Vgb	1921..>2110	CDD:443399
		LDL-receptor class B 17	1922..1964
		LY	1947..1987	CDD:214531
		LDL-receptor class B 28	1965..2007
		LDL-receptor class B 19	2008..2051
		LY	2033..2075	CDD:214531
		LDL-receptor class B 20	2052..2095
		FXa_inhibition	2147..2182	CDD:464251
		LDL-receptor class B 21	2239..2280
		LDL-receptor class B 22	2281..2329
		LDL-receptor class B 23	2330..2374
		Ldl_recept_b	2330..2372	CDD:459654
		LY	2355..2397	CDD:214531
		LDL-receptor class B 24	2375..2416
		LDL-receptor class B 25	2417..2459
		FXa_inhibition	2468..2502	CDD:464251
		LDLa	2514..2543	CDD:238060
		LDLa	2552..2586	CDD:238060
		LDLa	2591..2625	CDD:238060
LDLa	2645..2674	CDD:238060
LDLa	2682..2716	CDD:238060
LDLa	2720..2753	CDD:238060
LDLa	2760..2793	CDD:197566
LDLa	2844..2877	CDD:197566
LDLa	2891..2925	CDD:238060
FXa_inhibition	2937..2966	CDD:464251
EGF_CA	2968..2998	CDD:214542
LY	3035..3079	CDD:214531
LDL-receptor class B 26	3055..3098
LY	3080..3118	CDD:214531
LDL-receptor class B 27	3099..3141
LY	3123..3164	CDD:214531
LDL-receptor class B 28	3142..3185
LY	3167..3206	CDD:214531
LDL-receptor class B 29	3186..3224
LDL-receptor class B 30	3225..3268
FXa_inhibition	3277..3313	CDD:464251
LDLa	3317..3348	CDD:197566
LDLa	3357..3391	CDD:238060
LDLa	3396..3431	CDD:238060
LDLa	3436..3471	CDD:238060
LDLa	3476..3510	CDD:238060
LDLa	3515..3549	CDD:238060
LDLa	3553..3587	CDD:238060
LDLa	3594..3628	CDD:238060
LDLa	3632..3667	CDD:238060
LDLa	3674..3706	CDD:238060
LDLa	3721..3751	CDD:238060
LDLa	3762..3796	CDD:238060
EGF_CA	3844..3878	CDD:214542
LDL-receptor class B 31	3933..3980
LY	<3971..>3990	CDD:214531
LDL-receptor class B 32	3981..4038
LDL-receptor class B 33	4039..4082
Ldl_recept_b	4039..4080	CDD:459654
LY	4063..4102	CDD:214531
LDL-receptor class B 34	4083..4127
EGF_CA	4250..4284	CDD:238011
Endocytosis signal. /evidence=ECO:0000255	4492..4495
Endocytosis signal. /evidence=ECO:0000255	4559..4562