Protein Alignment CG6553 and LRP1

DIOPT Version :10

• Sequence 1: NP_610911.1
• Gene: CG6553 / 36537
• FlyBaseID: FBgn0033880
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_002323.2
• Gene: LRP1 / 4035
• HGNCID: 6692
• Length: 4544
• Species: Homo sapiens
• Alignment Length: 252
• Identity: 65/252 - (25%)
• Similarity: 90/252 - (35%)
• Gaps: 83/252 - (32%)

  Fly    23 CLGSQNATSCGHRCGGGD-------CIQLDQLCDGSANCLDGSDETVAMCEKVWCPGYAFRC-SY 79
            |...::.|.|...|....       ||....|||||.:|.||||| .|.||...|...:|.| ..
Human  2721 CEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE-AAHCEGKTCGPSSFSCPGT 2784

  Fly    80 GACIASTAVCDGVQDCVDGSDEQGWLCRAQMQQANCDNWEMYCSSGQCMTYSKLCDGIRDCRDGD 144
            ..|:....:|||.:||.||:||.  :....:..:.||:.|..|.:.||:....:||..|||.||.
Human  2785 HVCVPERWLCDGDKDCADGADES--IAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGS 2847

  Fly   145 DELESLCEGVTIPTTTVSSTTSTTTESSIHRITPTVPVTRKASRPNPLQENGECVVPQLPNVMVK 209
            |                                                |:.||..|
Human  2848 D------------------------------------------------ESPECEYP-------- 2856

  Fly   210 HFTDAILTVGS---RVANGTRIYYDCPAEHRLKGENQNICQD-ALWARKFPYCETPQ 262
                   |.|.   |.|||.     |.:..:.:.:.:|.|.| :..|.|.|:|.:.:
Human  2857 -------TCGPSEFRCANGR-----CLSSRQWECDGENDCHDQSDEAPKNPHCTSQE 2901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6553	NP_610911.1	LDLa	34..60	CDD:197566	12/32 (38%)
		LDLa	70..101	CDD:197566	11/31 (35%)
		LDLa	115..146	CDD:197566	13/30 (43%)
LRP1	NP_002323.2	LDLa	26..59	CDD:197566
		Ldl_recept_a	71..104	CDD:395011
		FXa_inhibition	119..148	CDD:464251
		FXa_inhibition	158..188	CDD:464251
		LY	275..314	CDD:214531
		LDL-receptor class B 1	292..334
		LY	316..358	CDD:214531
		LDL-receptor class B 2	335..378
		LY	361..401	CDD:214531
		LDL-receptor class B 3	379..422
		FXa_inhibition	486..519	CDD:464251
		LY	551..593	CDD:214531
		LDL-receptor class B 4	571..613
		LY	594..633	CDD:214531
		LDL-receptor class B 5	614..659
		LY	640..689	CDD:214531
		LDL-receptor class B 6	660..710
		LY	<700..733	CDD:214531
		LDL-receptor class B 7	711..754
		FXa_inhibition	807..842	CDD:464251
		LDLa	853..885	CDD:197566
		LDLa	895..928	CDD:238060
		LDLa	935..967	CDD:197566
		LDLa	978..1011	CDD:238060
		LDLa	1015..1048	CDD:238060
		LDLa	1062..1097	CDD:238060
		LDLa	1104..1140	CDD:238060
		LDLa	1145..1178	CDD:238060
		FXa_inhibition	1185..1221	CDD:464251
		LDL-receptor class B 8	1309..1355
		Vgb	1310..>1503	CDD:443399
		LY	1336..1376	CDD:214531
		LDL-receptor class B 9	1356..1398
		LY	1380..1423	CDD:214531
		LDL-receptor class B 10	1399..1445
		LDL-receptor class B 11	1446..1490
		LDL-receptor class B 12	1491..1531
		LY	1613..1649	CDD:214531
		LDL-receptor class B 13	1627..1669
		LY	1650..1693	CDD:214531
		LDL-receptor class B 14	1670..1713
		LY	1697..1734	CDD:214531
		LDL-receptor class B 15	1714..1753
		LY	1734..1775	CDD:214531
		LDL-receptor class B 16	1754..1798
		FXa_inhibition	1850..1886	CDD:464251
		YncE	1872..2084	CDD:442618
		LDL-receptor class B 17	1934..1976
		LY	1959..1999	CDD:214531
		LDL-receptor class B 18	1977..2019
		LDL-receptor class B 19	2020..2063
		Ldl_recept_b	2020..2061	CDD:459654
		LY	2045..2087	CDD:214531
		LDL-receptor class B 20	2064..2107
		FXa_inhibition	2159..2194	CDD:464251
		LDL-receptor class B 21	2253..2294
		LDL-receptor class B 22	2295..2343
		LDL-receptor class B 23	2344..2388
		Ldl_recept_b	2344..2386	CDD:459654
		LY	2370..2411	CDD:214531
		LDL-receptor class B 24	2389..2431
		LDL-receptor class B 25	2432..2473
		FXa_inhibition	2482..2517	CDD:464251
		LDLa	2527..2557	CDD:238060
LDLa	2566..2600	CDD:238060
LDLa	2605..2639	CDD:238060
LDLa	<2666..2688	CDD:238060
LDLa	2696..2730	CDD:238060	2/8 (25%)
LDLa	2734..2765	CDD:197566	12/30 (40%)
LDLa	2773..2806	CDD:197566	11/32 (34%)
LDLa	2817..2849	CDD:197566	14/79 (18%)
LDLa	2857..2890	CDD:197566	10/37 (27%)
LDLa	2907..2939	CDD:238060
cEGF	2964..2985	CDD:463661
EGF_CA	2982..>3011	CDD:214542
LY	3049..3093	CDD:214531
LDL-receptor class B 26	3069..3113
LY	3094..3136	CDD:214531
LDL-receptor class B 27	3114..3156
LY	3138..3180	CDD:214531
LDL-receptor class B 28	3157..3200
LY	3182..3223	CDD:214531
LDL-receptor class B 29	3201..3243
LY	3224..3264	CDD:214531
LDL-receptor class B 30	3244..3284
FXa_inhibition	3294..3330	CDD:464251
LDLa	3334..3365	CDD:238060
LDLa	3374..3408	CDD:238060
LDLa	3413..3448	CDD:238060
LDLa	3452..3485	CDD:197566
LDLa	3493..3526	CDD:197566
LDLa	3536..3570	CDD:238060
LDLa	3575..3609	CDD:238060
LDLa	3613..3647	CDD:238060
LDLa	3653..3685	CDD:197566
LDLa	3695..3731	CDD:238060
LDLa	3746..3776	CDD:238060
YncE	3862..4064	CDD:442618
LDL-receptor class B 31	3912..3954
Recognition site for proteolytical processing. /evidence=ECO:0000255	3940..3943
LY	3955..3992	CDD:214531
LDL-receptor class B 32	3970..4012
LDL-receptor class B 33	4013..4056
Ldl_recept_b	4013..4054	CDD:459654
LY	4037..4078	CDD:214531
LDL-receptor class B 34	4057..4101
Interaction with MAFB. /evidence=ECO:0000250|UniProtKB:Q91ZX7	4445..4544
NPXY motif	4502..4507