Protein Alignment CG6553 and Lrp1

DIOPT Version :10

• Sequence 1: NP_610911.1
• Gene: CG6553 / 36537
• FlyBaseID: FBgn0033880
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: XP_036011543.1
• Gene: Lrp1 / 16971
• MGIID: 96828
• Length: 4562
• Species: Mus musculus
• Alignment Length: 250
• Identity: 65/250 - (26%)
• Similarity: 90/250 - (36%)
• Gaps: 79/250 - (31%)

  Fly    23 CLGSQNATSCGHRCGGGD-------CIQLDQLCDGSANCLDGSDETVAMCEKVWCPGYAFRC-SY 79
            |...::.|.|...|....       ||....|||||.:|.||||| .|.||...|...:|.| ..
Mouse  2739 CENGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE-AAHCEGKTCGPSSFSCPGT 2802

  Fly    80 GACIASTAVCDGVQDCVDGSDEQGWLCRAQMQQANCDNWEMYCSSGQCMTYSKLCDGIRDCRDGD 144
            ..|:....:|||.:||.||:||.  :....:..:.||:.|..|.:..|:....:||..|||.||.
Mouse  2803 HVCVPERWLCDGDKDCTDGADES--VTAGCLYNSTCDDREFMCQNRLCIPKHFVCDHDRDCADGS 2865

  Fly   145 DELESLCEGVTIPTTTVSSTTSTTTESSIHRITPTVPVTRKASRPNPLQENGECVVPQL-PNVMV 208
            |                                                |:.||..|.. ||..
Mouse  2866 D------------------------------------------------ESPECEYPTCGPNEF- 2881

  Fly   209 KHFTDAILTVGSRVANGTRIYYDCPAEHRLKGENQNICQD-ALWARKFPYCETPQ 262
                        |.|||.     |.:..:.:.:.:|.|.| :..|.|.|:|.:|:
Mouse  2882 ------------RCANGR-----CLSSRQWECDGENDCHDHSDEAPKNPHCTSPE 2919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6553	NP_610911.1	LDLa	34..60	CDD:197566	12/32 (38%)
		LDLa	70..101	CDD:197566	11/31 (35%)
		LDLa	115..146	CDD:197566	12/30 (40%)
Lrp1	XP_036011543.1	LDLa	27..60	CDD:197566
		LDLa	72..105	CDD:197566
		FXa_inhibition	120..149	CDD:464251
		FXa_inhibition	159..189	CDD:464251
		LY	276..315	CDD:214531
		LY	317..359	CDD:214531
		LY	362..402	CDD:214531
		FXa_inhibition	487..520	CDD:464251
		LY	552..594	CDD:214531
		LY	595..634	CDD:214531
		LY	641..690	CDD:214531
		LY	<701..734	CDD:214531
		FXa_inhibition	808..843	CDD:464251
		LDLa	854..886	CDD:197566
		LDLa	896..929	CDD:238060
		LDLa	936..968	CDD:197566
		LDLa	979..1012	CDD:238060
		LDLa	1033..1066	CDD:238060
		LDLa	1080..1115	CDD:238060
		LDLa	1122..1158	CDD:238060
		LDLa	1163..1196	CDD:238060
		FXa_inhibition	1203..1239	CDD:464251
		Vgb	1328..>1521	CDD:443399
		LY	1354..1394	CDD:214531
		LY	1398..1441	CDD:214531
		LY	1631..1667	CDD:214531
		LY	1668..1711	CDD:214531
		LY	1715..1752	CDD:214531
		LY	1752..1793	CDD:214531
		FXa_inhibition	1868..1904	CDD:464251
		LY	1934..1974	CDD:214531
		LY	1977..2017	CDD:214531
		LY	2018..2061	CDD:214531
		LY	2063..2105	CDD:214531
		FXa_inhibition	2177..2212	CDD:464251
		LY	2293..2333	CDD:214531
		Ldl_recept_b	2362..2404	CDD:459654
		LY	2388..2429	CDD:214531
		FXa_inhibition	2500..2532	CDD:464251
		LDLa	2545..2575	CDD:238060
		LDLa	2584..2618	CDD:238060
		LDLa	2623..2657	CDD:238060
		LDLa	<2684..2706	CDD:238060
		LDLa	2714..2748	CDD:238060	2/8 (25%)
		LDLa	2752..2783	CDD:197566	12/30 (40%)
		LDLa	2791..2824	CDD:197566	11/32 (34%)
		LDLa	2835..2867	CDD:197566	13/79 (16%)
		LDLa	2875..2908	CDD:197566	10/50 (20%)
		LDLa	2925..2957	CDD:238060
		FXa_inhibition	2969..2998	CDD:464251
		EGF_CA	3000..>3029	CDD:214542
		LY	3067..3111	CDD:214531
		LY	3112..3154	CDD:214531
		LY	3156..3198	CDD:214531
		LY	3200..3241	CDD:214531
		LY	3242..3282	CDD:214531
		FXa_inhibition	3312..3348	CDD:464251
		LDLa	3352..3383	CDD:238060
		LDLa	3392..3426	CDD:238060
		LDLa	3431..3466	CDD:238060
		LDLa	3470..3503	CDD:197566
		LDLa	3511..3544	CDD:197566
		LDLa	3554..3588	CDD:238060
		LDLa	3593..3627	CDD:238060
LDLa	3631..3665	CDD:238060
LDLa	3671..3703	CDD:197566
LDLa	3713..3749	CDD:238060
LDLa	3764..3794	CDD:238060
YncE	3880..4082	CDD:442618
LY	3973..4010	CDD:214531
Ldl_recept_b	4031..4072	CDD:459654
LY	4055..4096	CDD:214531