Protein Alignment CG6553 and LDLRAD3

DIOPT Version :10

• Sequence 1: NP_610911.1
• Gene: CG6553 / 36537
• FlyBaseID: FBgn0033880
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_777562.1
• Gene: LDLRAD3 / 143458
• HGNCID: 27046
• Length: 345
• Species: Homo sapiens
• Alignment Length: 169
• Identity: 57/169 - (33%)
• Similarity: 73/169 - (43%)
• Gaps: 16/169 - (9%)

  Fly    12 LVIFLSLAVTICL--GSQNATSC----GHRCGGGDCIQLDQLCDGSANCLDGSDETVAMCEKVWC 70
            |.:.||.|....|  |:.....|    ...|..|.||.....|||..:|.|.|||......|..|
Human     7 LCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKC 71

  Fly    71 PGYAFRCSYGA-CIASTAVCDGVQDCVDGSDEQGWLCRAQMQQANCDNWEMYCSSGQCMTYSKLC 134
            ....|.|:.|. ||.....|:|.:||.|||||:.  |.|  ....|.....:|.:|.|:..|.:|
Human    72 GPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEEN--CTA--NPLLCSTARYHCKNGLCIDKSFIC 132

  Fly   135 DGIRDCRDGDDELESLCEGVTIPTTTVSSTTSTTTESSI 173
            ||..:|:|..|| || ||....|.   |.....|:|:.:
Human   133 DGQNNCQDNSDE-ES-CESSQEPG---SGQVFVTSENQL 166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6553	NP_610911.1	LDLa	34..60	CDD:197566	10/25 (40%)
		LDLa	70..101	CDD:197566	13/31 (42%)
		LDLa	115..146	CDD:197566	10/30 (33%)
LDLRAD3	NP_777562.1	(Microbial infection) Interaction with Venezuelan equine encephalitis virus/VEEV spike proteins E1 and E2. /evidence=ECO:0000269|PubMed:34646021	30..57		8/26 (31%)
		LDLa	32..64	CDD:238060	12/31 (39%)
		LDLa	71..106	CDD:238060	15/36 (42%)
		LDLa	113..147	CDD:238060	14/35 (40%)
		Involved in ITCH interaction. /evidence=ECO:0000269|PubMed:26854353	256..259
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..345
		Involved in ITCH interaction. /evidence=ECO:0000269|PubMed:26854353	275..278