DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Echs1 and Eci3

DIOPT Version :9

Sequence 1:	NP_610910.1	Gene:	Echs1 / 36536	FlyBaseID:	FBgn0033879	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_081223.1	Gene:	Eci3 / 69123	MGIID:	1916373	Length:	317	Species:	Mus musculus

Alignment Length:	284	Identity:	74/284 - (26%)
Similarity:	128/284 - (45%)	Gaps:	42/284 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VATRFSSSSTNNNWEYIKTEVAGEGKNVGV--------ITLNRPKALNALCNGLMKELSTALQQF 81
            |::..|||...:..:....|.|.|.|::.|        ||.|||...||:...:..::..||:..
Mouse    37 VSSLSSSSEAPSQGKRGADEKARESKDILVTSEDGITKITFNRPTKKNAISFQMYLDIMHALKNA 101

  Fly    82 SKDKTISAIVLTGSEKAFAAGADIKEMVGN--------TYSQCIQGNFLNDWTEVARTQKPIIAA 138
            |.|.:: ..|.||:...:::|.|:|.::.:        ..|..|...|:|.:.:.   .||::|.
Mouse   102 STDNSV-ITVFTGTGDYYSSGNDLKNLINDAGEIQDVVATSTKILREFVNCFIDF---PKPLVAV 162

  Fly   139 VNGYALGGGCELAMMCDIIYAGDKAKFGQPEIALGTIPGAGGTQRLTRVVGKSKAMEMCLTGNMI 203
            |||.|:|....:..:.|.::|.|:|.|..|...|..||.|..|....:::|.:||.||.|.|..:
Mouse   163 VNGPAVGIAVTILALFDAVFASDRATFHTPFSQLSQIPEACSTYMFPKIMGPTKAAEMLLFGKKL 227

  Fly   204 GAQEAEKLGLASKVVPADQLLGEAVKLGEKIGTHSNL---IVQLCKEAVNTAYETTLQEGLKFER 265
            .|:||...||.::|.|....   ..::..::.|:|.|   ::::.||.:.           |.|:
Mouse   228 TAREAWAQGLVTEVFPESTF---ETEVWTRLKTYSKLSPNVMRISKELIR-----------KHEK 278

  Fly   266 RTFHATFSTADRKEGMTAFAEKRP 289
            :..:..     ..|...|..|:.|
Mouse   279 QKLYTV-----NAEECAAALERMP 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Echs1	NP_610910.1	crotonase-like	37..294	CDD:304874	70/272 (26%)
Eci3	NP_081223.1	ACBP	<2..37	CDD:376410	74/284 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..60		5/19 (26%)
		crotonase-like	64..256	CDD:119339	55/198 (28%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q05871	120..124		1/3 (33%)
		Microbody targeting signal. /evidence=ECO:0000255	315..317
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810