DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Echs1 and ech-6

DIOPT Version :9

Sequence 1:	NP_610910.1	Gene:	Echs1 / 36536	FlyBaseID:	FBgn0033879	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_001366674.1	Gene:	ech-6 / 176376	WormBaseID:	WBGene00001155	Length:	288	Species:	Caenorhabditis elegans

Alignment Length:	280	Identity:	181/280 - (64%)
Similarity:	216/280 - (77%)	Gaps:	5/280 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQAAARQPQVATRFSSSSTNNNWEYIKTEVAGEGKNVGVITLNRPKALNALCNGLMKELSTALQQ 80
            |.|...|.|||. |||.:.    |.||.|..||.:||.:|.|||||||||||..||.||:.||:.
Worm    14 LCANVNQMQVAA-FSSKAP----EMIKIEKVGEKQNVALIKLNRPKALNALCAQLMTELADALEV 73

  Fly    81 FSKDKTISAIVLTGSEKAFAAGADIKEMVGNTYSQCIQGNFLNDWTEVARTQKPIIAAVNGYALG 145
            ...||::.|||:||||:|||||||||||..|.::....|:||::||.|:..:||:||||||:|||
Worm    74 LDTDKSVGAIVITGSERAFAAGADIKEMTNNEFATTFSGSFLSNWTAVSDVKKPVIAAVNGFALG 138

  Fly   146 GGCELAMMCDIIYAGDKAKFGQPEIALGTIPGAGGTQRLTRVVGKSKAMEMCLTGNMIGAQEAEK 210
            ||.||||||||||||:||:||||||.:|||||||||||..|..|||.|||:|||||.:.||||::
Worm   139 GGNELAMMCDIIYAGEKARFGQPEINIGTIPGAGGTQRWARAAGKSFAMEVCLTGNHVTAQEAKE 203

  Fly   211 LGLASKVVPADQLLGEAVKLGEKIGTHSNLIVQLCKEAVNTAYETTLQEGLKFERRTFHATFSTA 275
            .|:.||:.||||::||||||||||...|.||||:.|||||.|||.||||||.||||.|||||:|.
Worm   204 HGIVSKIFPADQVVGEAVKLGEKIADQSPLIVQMAKEAVNKAYELTLQEGLHFERRLFHATFATK 268

  Fly   276 DRKEGMTAFAEKRPAKFTNE 295
            |||||||||||||..::.::
Worm   269 DRKEGMTAFAEKRKPQWESK 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Echs1	NP_610910.1	crotonase-like	37..294	CDD:304874	172/256 (67%)
ech-6	NP_001366674.1	crotonase-like	32..284	CDD:419961	172/251 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166681
Domainoid	1	1.000	332	1.000	Domainoid score	I604
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3018
Inparanoid	1	1.050	345	1.000	Inparanoid score	I1373
Isobase	1	0.950	-	0	Normalized mean entropy	S1663
OMA	1	1.010	-	-		QHG61099
OrthoDB	1	1.010	-	-		D1221604at2759
OrthoFinder	1	1.000	-	-		FOG0003513
OrthoInspector	1	1.000	-	-		oto19565
orthoMCL	1	0.900	-	-		OOG6_101534
Panther	1	1.100	-	-	LDO	PTHR11941
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2501
SonicParanoid	1	1.000	-	-		X3958
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790