DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Echs1 and Echs1

DIOPT Version :9

Sequence 1:	NP_610910.1	Gene:	Echs1 / 36536	FlyBaseID:	FBgn0033879	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_511178.1	Gene:	Echs1 / 140547	RGDID:	69330	Length:	290	Species:	Rattus norvegicus

Alignment Length:	282	Identity:	170/282 - (60%)
Similarity:	213/282 - (75%)	Gaps:	4/282 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RAQCVLQAAARQPQVATRFSSSSTNNNWEYIKTEVAGEGKNVGVITLNRPKALNALCNGLMKELS 75
            ||...|.:..|.|:. .||:|.:   |::||.||..|:..:||:|.||||||||||||||::||:
  Rat    10 RACNSLLSPVRCPEF-RRFASGA---NFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELN 70

  Fly    76 TALQQFSKDKTISAIVLTGSEKAFAAGADIKEMVGNTYSQCIQGNFLNDWTEVARTQKPIIAAVN 140
            .||:.|.:|..:.||||||.|||||||||||||...|:..|..|.||:.|..:.|.:||:|||||
  Rat    71 QALETFEEDPAVGAIVLTGGEKAFAAGADIKEMQNRTFQDCYSGKFLSHWDHITRIKKPVIAAVN 135

  Fly   141 GYALGGGCELAMMCDIIYAGDKAKFGQPEIALGTIPGAGGTQRLTRVVGKSKAMEMCLTGNMIGA 205
            ||||||||||||||||||||:||:||||||.|||||||||||||||.||||.||||.|||:.|.|
  Rat   136 GYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISA 200

  Fly   206 QEAEKLGLASKVVPADQLLGEAVKLGEKIGTHSNLIVQLCKEAVNTAYETTLQEGLKFERRTFHA 270
            |:|::.||.||:.|.:.|:.||::..|||..:|.:||.:.||:||.|:|.||.||.|.|::.|::
  Rat   201 QDAKQAGLVSKIFPVETLVEEAIQCAEKIANNSKIIVAMAKESVNAAFEMTLTEGNKLEKKLFYS 265

  Fly   271 TFSTADRKEGMTAFAEKRPAKF 292
            ||:|.||:|||:||.|||.|.|
  Rat   266 TFATDDRREGMSAFVEKRKANF 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Echs1	NP_610910.1	crotonase-like	37..294	CDD:304874	162/256 (63%)
Echs1	NP_511178.1	crotonase-like	32..288	CDD:419961	159/255 (62%)
Echs1	NP_511178.1	Substrate binding	98..101		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353106
Domainoid	1	1.000	322	1.000	Domainoid score	I1181
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3018
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2324
OMA	1	1.010	-	-		QHG61099
OrthoDB	1	1.010	-	-		D1221604at2759
OrthoFinder	1	1.000	-	-		FOG0003513
OrthoInspector	1	1.000	-	-		oto97641
orthoMCL	1	0.900	-	-		OOG6_101534
Panther	1	1.100	-	-	LDO	PTHR11941
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3958
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770