DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Echs1 and Cdyl

DIOPT Version :9

Sequence 1:	NP_610910.1	Gene:	Echs1 / 36536	FlyBaseID:	FBgn0033879	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_034011.1	Gene:	Cdyl / 12593	MGIID:	1339956	Length:	593	Species:	Mus musculus

Alignment Length:	274	Identity:	64/274 - (23%)
Similarity:	124/274 - (45%)	Gaps:	13/274 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RFSSSSTNNNWEYIKTEVAGEGKNVGVITLNRPKALNALCNGLMKELSTALQQFSKDKTISAIVL 92
            |||...|.:.:.|....|..:.....::...:....|:|...:|||:.:||...:.|.: ..::|
Mouse   324 RFSVRQTESAYRYRDIVVRKQDGFTHILLSTKSSENNSLNPEVMKEVQSALSTAAADDS-KLVLL 387

  Fly    93 TGSEKAFAAGAD----IKEMVGNTYSQCIQ-----GNFLNDWTEVARTQKPIIAAVNGYALGGGC 148
            :.....|..|.|    |:.:..:...:..:     .||:|.:.:.   :||||.||||.|:|.|.
Mouse   388 SAVGSVFCCGLDFIYFIRRLTDDRKRESTKMADAIRNFVNTFIQF---KKPIIVAVNGPAIGLGA 449

  Fly   149 ELAMMCDIIYAGDKAKFGQPEIALGTIPGAGGTQRLTRVVGKSKAMEMCLTGNMIGAQEAEKLGL 213
            .:..:||:::|.:||.|..|....|..|....|....:::|.:.|.||..:|..:.||||...||
Mouse   450 SILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLFSGRKLTAQEACGKGL 514

  Fly   214 ASKVVPADQLLGEAVKLGEKIGTHSNLIVQLCKEAVNTAYETTLQEGLKFERRTFHATFSTADRK 278
            .|:|........|.:...:::.:.:.::::..|..|....:..|::..:.|.......:.:|...
Mouse   515 VSQVFWPGTFTQEVMVRIKELASCNPVVLEESKALVRCNMKMELEQANERECEVLKKIWGSAQGM 579

  Fly   279 EGMTAFAEKRPAKF 292
            :.|..:.:::..:|
Mouse   580 DSMLKYLQRKIDEF 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Echs1	NP_610910.1	crotonase-like	37..294	CDD:304874	60/265 (23%)
Cdyl	NP_034011.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		CHROMO	55..109	CDD:214605
		Interaction with EZH2. /evidence=ECO:0000250\|UniProtKB:Q9Y232	56..304
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..223
		crotonase-like	339..535	CDD:119339	52/199 (26%)
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	357..589		57/235 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810