DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syngr and SYNGR1

DIOPT Version :9

Sequence 1:	NP_610908.1	Gene:	Syngr / 36533	FlyBaseID:	FBgn0033876	Length:	241	Species:	Drosophila melanogaster
Sequence 2:	NP_004702.2	Gene:	SYNGR1 / 9145	HGNCID:	11498	Length:	233	Species:	Homo sapiens

Alignment Length:	237	Identity:	96/237 - (40%)
Similarity:	133/237 - (56%)	Gaps:	32/237 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GGAYGGGKAGGAFDPLTFAMKPQVVIRALCWLFSVVVFGCISSEGW--TEKDGKEYCLYNGDGMA 75
            |||||.|||||||||.|...:|..::|.:.||||:||||.|.:||:  :..:|:|:|:||.:..|
Human     3 GGAYGAGKAGGAFDPYTLVRQPHTILRVVSWLFSIVVFGSIVNEGYLNSASEGEEFCIYNRNPNA 67

  Fly    76 CKYGNMVGVFGFLASMGFMGGEFLFERMSSVKSRKRYVMADMGFSALWTFMYFVAFLYLWSQWSS 140
            |.||..|||..||..:.::..:..|.::||||.||:.|::|:|.||.|.|::||.|.||.:||..
Human    68 CSYGVAVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSAFWAFLWFVGFCYLANQWQV 132

  Fly   141 SAPP--PLGIGAGSMKTAIWFCLFSIVSWALCALMAYKRFLIGAGDEFTSAFETDPANVVHQQAY 203
            |.|.  ||..|..:.:.||.|..|||.:||..|::|::|:.|||.....|....||:
Human   133 SKPKDNPLNEGTDAARAAIAFSFFSIFTWAGQAVLAFQRYQIGADSALFSQDYMDPS-------- 189

  Fly   204 GYSMDNDNDQYSASPFGQ------PQQGGMEQQQSGMEYQQP 239
                     |.|:.|:..      |...||     |..||||
Human   190 ---------QDSSMPYAPYVEPTGPDPAGM-----GGTYQQP 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syngr	NP_610908.1	MARVEL	34..169	CDD:307448	60/138 (43%)
SYNGR1	NP_004702.2	MARVEL	21..167	CDD:279608	62/145 (43%)
SYNGR1	NP_004702.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..233		9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157821
Domainoid	1	1.000	127	1.000	Domainoid score	I5355
eggNOG	1	0.900	-	-		E1_KOG4016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3456
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4079
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45451
OrthoDB	1	1.010	-	-		D1549362at2759
OrthoFinder	1	1.000	-	-		FOG0001420
OrthoInspector	1	1.000	-	-		otm40745
orthoMCL	1	0.900	-	-		OOG6_104437
Panther	1	1.100	-	-	O	PTHR10838
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2805
SonicParanoid	1	1.000	-	-		X989
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800