DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6357 and Ctsr

DIOPT Version :9

Sequence 1:	NP_610907.1	Gene:	CG6357 / 36532	FlyBaseID:	FBgn0033875	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_064680.1	Gene:	Ctsr / 56835	MGIID:	1861723	Length:	334	Species:	Mus musculus

Alignment Length:	334	Identity:	71/334 - (21%)
Similarity:	113/334 - (33%)	Gaps:	116/334 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LYLMGVALGVPVSTSSPATQKINPEIGVTTGKSDADSSTPTIEHTSGLSEFEEECQFAWQRFLVD 78
            ||| |||.||||..||                .||:                      ||    |
Mouse    10 LYL-GVASGVPVLDSS----------------LDAE----------------------WQ----D 31

  Fly    79 FDVHYDNDY---ERQKRRDIFCENWQKVRDHNLKYDLGVVSFKKGINQWSDLTFEEWKEKQTPKV 140
            :.:.|:..|   |.:.:|.::.|..:.::.||.:..||...|...:|::.|.|.||::     |:
Mouse    32 WKIKYNKSYSLKEEKLKRVVWEEKLKMIKLHNRENSLGKNGFTMKMNEFGDQTDEEFR-----KM 91

  Fly   141 MPEIASESSKEERDKVNCQAAWEKFLIDFGAQYKNANETEKRRNVFC-ANWRAIVEHNVQYEK-W 203
            |.||:..:.:|.:..:..:|.  ..|..|....|....|..||...| |.|...|...::.:. |
Mouse    92 MIEISVWTHREGKSIMKREAG--SILPKFVDWRKKGYVTPVRRQGDCDACWAFAVTGAIEAQAIW 154

  Fly   204 AEPFKRDINQWTDHTIEERSSPAPEIRKEEATTSTSEIDNDNII-CQPAWEKFLIDFKPSYQDDT 267
                                          .|...:.:...|:: |.          ||...:..
Mouse   155 ------------------------------QTGKLTPLSVQNLVDCS----------KPQGNNGC 179

  Fly   268 ETEKRRNVFCDNFKSIHKHNVQFDLGNISFKKGINQWSDLTVEEWKNKQRPA-FNPEFSKVEATT 331
            ......|.|            |:.|.|...:      |:.|. .::.|..|. :||:.||.|.|.
Mouse   180 LGGDTYNAF------------QYVLHNGGLE------SEATY-PYEGKDGPCRYNPKNSKAEITG 225

  Fly   332 KISKDKRDD 340
            .:|..:.:|
Mouse   226 FVSLPQSED 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6357	NP_610907.1	Inhibitor_I29	72..132	CDD:285458	17/62 (27%)
		Inhibitor_I29	162..221	CDD:214853	11/60 (18%)
		Inhibitor_I29	252..311	CDD:214853	9/58 (16%)
		Inhibitor_I29	347..406	CDD:214853
Ctsr	NP_064680.1	PTZ00203	15..332	CDD:185513	66/328 (20%)
		Inhibitor_I29	29..87	CDD:214853	16/61 (26%)
		Peptidase_C1A	116..332	CDD:239068	32/178 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910