DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6357 and ctsba

DIOPT Version :9

Sequence 1:	NP_610907.1	Gene:	CG6357 / 36532	FlyBaseID:	FBgn0033875	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_998501.1	Gene:	ctsba / 406645	ZFINID:	ZDB-GENE-040426-2650	Length:	330	Species:	Danio rerio

Alignment Length:	329	Identity:	56/329 - (17%)
Similarity:	83/329 - (25%)	Gaps:	163/329 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 EEWKEKQTPKVMPEIASESSKEERDKVNCQAAWEKFLIDFGAQYKNANETEKRRNVFCANWRAIV 194
            |:|....|           .||.||:.:|.:.|.     |||.     |....|....::.:..|
Zfish    87 EQWPNCPT-----------LKEIRDQGSCGSCWA-----FGAA-----EAISDRVCIHSDAKVSV 130

  Fly   195 EHNVQ---------------------YEKWA---------------------EPFKRDINQWTDH 217
            |.:.|                     ::.||                     ||.:..:|
Zfish   131 EISSQDLLTCCDSCGMGCNGGYPSAAWDFWATEGLVTGGLYNSHIGCRPYTIEPCEHHVN----- 190

  Fly   218 TIEERSSPAPEIRKEEATTSTSEIDNDNIICQPAWEKFLIDFKPSYQDDTETEKRRNVFCDNFKS 282
                  ...|....|...|     .|.::.|:|.       :.|||:.|
Zfish   191 ------GSRPPCSGEGGDT-----PNCDMKCEPG-------YSPSYKQD---------------- 221

  Fly   283 IHKHNVQFDLGNISFKKGINQWSDLTVEEWKNKQRPAFNPEFSKVEATTKISKDKRDDNTCQAAW 347
              ||     .|..|:....|| :.:..|.:||          ..||....:.:|
Zfish   222 --KH-----FGKTSYSVPSNQ-NSIMAELFKN----------GPVEGAFTVYED----------- 257

  Fly   348 KKFLIDFGAKYQDEKETEKRRTIFCDNWKAIQEHNEQFELGVESFK-------KGINQWSDLTVE 405
              ||:.....||                     |.....:|..:.|       .|:..|  |...
Zfish   258 --FLLYKSGVYQ---------------------HMSGSPVGGHAIKILGWGEENGVPYW--LAAN 297

  Fly   406 EWKT 409
            .|.|
Zfish   298 SWNT 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6357	NP_610907.1	Inhibitor_I29	72..132	CDD:285458	1/1 (100%)
		Inhibitor_I29	162..221	CDD:214853	14/100 (14%)
		Inhibitor_I29	252..311	CDD:214853	10/58 (17%)
		Inhibitor_I29	347..406	CDD:214853	10/65 (15%)
ctsba	NP_998501.1	Propeptide_C1	25..64	CDD:285358
ctsba	NP_998501.1	Peptidase_C1A_CathepsinB	80..327	CDD:239111	56/329 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900