DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6357 and cpr-8

DIOPT Version :9

Sequence 1:	NP_610907.1	Gene:	CG6357 / 36532	FlyBaseID:	FBgn0033875	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_503384.1	Gene:	cpr-8 / 178613	WormBaseID:	WBGene00021070	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	319	Identity:	62/319 - (19%)
Similarity:	99/319 - (31%)	Gaps:	122/319 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 VDFDVHYDNDYERQKRRDIFCENWQK-----VRDHNLK---YDLGVVSFK---KGINQW-SDLT- 128
            :|..:||.|.   ||      ..|..     .|:..||   .|...:.||   .|::|. |||:
Worm    23 IDRIIHYVNS---QK------TTWTAGIPALSRNSMLKTLVTDAATIGFKIQNFGVSQANSDLSP 78

  Fly   129 ----FEEWKEKQTPKVMPEIASESSKEERDKVNCQAAW---------EKFLIDFGAQYKN----- 175
                .|.|.|..:   :|:|        .|...|:.:|         ::..|:.|. :||
Worm    79 SFDARERWPECMS---IPQI--------NDISECKTSWAFAAAESMSDRLCINSGG-FKNTILSA 131

  Fly   176 ------------ANETEKRRNVFCANWRAIVEHNV----QYEK--WAEPFK-----RDINQWTDH 217
                        ..|..:..|.|.| |:.|.:|.:    .||.  ..:|:.     :.:...|..
Worm   132 EELLSCCTGMFSCGEGCEGGNPFKA-WQYIQKHGIPTGGSYESQFGCKPYSIPPCGKTVGNVTYP 195

  Fly   218 TIEERSSPAPEIRK----------------------EEATTSTSEIDNDNIICQPAWEKFLIDFK 260
            .....:||.|...|                      ::...|..||.:|.::..|....|.:
Worm   196 ACTNTTSPTPSCEKKCTSRIGYPIDIDKDRHYGVSVDQLPNSQIEIQSDVMLNGPIQATFEV--- 257

  Fly   261 PSYQDDTETEKRRNVFCDNFKSIHKHNVQFDLGNISFK-------KGINQWSDLTVEEW 312
              |.|          |......|:.|......|::|.:       :|:..|  |....|
Worm   258 --YDD----------FLQYTTGIYVHLTGNKQGHLSVRIIGWGVWQGVPYW--LCANSW 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6357	NP_610907.1	Inhibitor_I29	72..132	CDD:285458	19/71 (27%)
		Inhibitor_I29	162..221	CDD:214853	16/95 (17%)
		Inhibitor_I29	252..311	CDD:214853	11/65 (17%)
		Inhibitor_I29	347..406	CDD:214853
cpr-8	NP_503384.1	Propeptide_C1	24..>40	CDD:369701	7/24 (29%)
cpr-8	NP_503384.1	Peptidase_C1A_CathepsinB	79..330	CDD:239111	44/254 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900