DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6357 and CTSW

DIOPT Version :9

Sequence 1:	NP_610907.1	Gene:	CG6357 / 36532	FlyBaseID:	FBgn0033875	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001326.3	Gene:	CTSW / 1521	HGNCID:	2546	Length:	376	Species:	Homo sapiens

Alignment Length:	375	Identity:	75/375 - (20%)
Similarity:	116/375 - (30%)	Gaps:	157/375 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ECQFAWQRFLVDFDVHYDNDYERQKRRDIFCENW---QKVRDHNLKYDLGVVSFKKGINQWSDLT 128
            |.:.|::.|.:.|:..|.:..|...|.|||..|.   |::::.    |||...|  |:..:||||
Human    37 ELKEAFKLFQIQFNRSYLSPEEHAHRLDIFAHNLAQAQRLQEE----DLGTAEF--GVTPFSDLT 95

  Fly   129 FEEWKEKQ--------TPKVMPEIASESSKEE-----------------RDKVNCQAAWE----- 163
            .||:.:..        .|.:..||.||..:|.                 :|:.||...|.
Human    96 EEEFGQLYGYRRAAGGVPSMGREIRSEEPEESVPFSCDWRKVASAISPIKDQKNCNCCWAMAAAG 160

  Fly   164 ------------------KFLIDFG----------------AQYKNANETEKRRNVFCANWRAIV 194
                              :.|:|.|                ....|:....::...|....||..
Human   161 NIETLWRISFWDFVDVSVQELLDCGRCGDGCHGGFVWDAFITVLNNSGLASEKDYPFQGKVRAHR 225

  Fly   195 EHNVQYEK--WAEPFKRDINQWTDH------------TIEERSSPAPEIRKE--EATTSTSEIDN 243
            .|..:|:|  |.:.|  .:.|..:|            |:.....|....||.  :||.:|
Human   226 CHPKKYQKVAWIQDF--IMLQNNEHRIAQYLATYGPITVTINMKPLQLYRKGVIKATPTT----- 283

  Fly   244 DNIICQPAWEKFLIDFKPSYQDDTETEKRRNVFCDNFKSIHKHNVQF-DLGNISFKKGINQWSDL 307
                |.|.    |:|                           |:|.. ..|::..::||  |::
Human   284 ----CDPQ----LVD---------------------------HSVLLVGFGSVKSEEGI--WAE- 310

  Fly   308 TVEEWKNKQRPAFNPEFSKVEATTKISKDK--------------RDDNTC 343
            ||......|.|...|.:        |.|:.              |..|||
Human   311 TVSSQSQPQPPHPTPYW--------ILKNSWGAQWGEKGYFRLHRGSNTC 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6357	NP_610907.1	Inhibitor_I29	72..132	CDD:285458	20/62 (32%)
		Inhibitor_I29	162..221	CDD:214853	16/111 (14%)
		Inhibitor_I29	252..311	CDD:214853	10/59 (17%)
		Inhibitor_I29	347..406	CDD:214853
CTSW	NP_001326.3	Inhibitor_I29	42..98	CDD:214853	19/61 (31%)
CTSW	NP_001326.3	Peptidase_C1A	129..358	CDD:239068	46/277 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900