DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6357 and CTSK

DIOPT Version :9

Sequence 1:	NP_610907.1	Gene:	CG6357 / 36532	FlyBaseID:	FBgn0033875	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_000387.1	Gene:	CTSK / 1513	HGNCID:	2536	Length:	329	Species:	Homo sapiens

Alignment Length:	146	Identity:	31/146 - (21%)
Similarity:	54/146 - (36%)	Gaps:	35/146 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EEECQFAWQRFLVDFDVHYDNDYERQKRRDIFCENWQKVRDHNLKYDLGVVSFKKGINQWSDLTF 129
            ||.....|:.:.......|:|..:...||.|:.:|.:.:..|||:..|||.:::..:|...|:|.
Human    19 EEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTS 83

  Fly   130 EEWKEKQTPKVMPEIASESSKEERDKVNCQAAWEKFLIDFGAQYKNANETEKRRNVFCANWRAIV 194
            ||..:|.|...:|                            ..:..:|:|     ::...|....
Human    84 EEVVQKMTGLKVP----------------------------LSHSRSNDT-----LYIPEWEGRA 115

  Fly   195 EHNVQYEK--WAEPFK 208
            ..:|.|.|  :..|.|
Human   116 PDSVDYRKKGYVTPVK 131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6357	NP_610907.1	Inhibitor_I29	72..132	CDD:285458	17/59 (29%)
		Inhibitor_I29	162..221	CDD:214853	8/49 (16%)
		Inhibitor_I29	252..311	CDD:214853
		Inhibitor_I29	347..406	CDD:214853
CTSK	NP_000387.1	Inhibitor_I29	26..85	CDD:214853	16/58 (28%)
CTSK	NP_000387.1	Peptidase_C1	115..327	CDD:306594	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12369
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910