DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6357 and CTSH

DIOPT Version :9

Sequence 1:	NP_610907.1	Gene:	CG6357 / 36532	FlyBaseID:	FBgn0033875	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_004381.2	Gene:	CTSH / 1512	HGNCID:	2535	Length:	335	Species:	Homo sapiens

Alignment Length:	270	Identity:	59/270 - (21%)
Similarity:	94/270 - (34%)	Gaps:	90/270 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 ERQKRRDIFCENWQKVRDHNLKYDLGVVSFKKGINQWSDLTFEE------WKEKQTPKVMPEIAS 146
            |...|...|..||:|:..||    .|..:||..:||:||::|.|      |.|.|
Human    50 EYHHRLQTFASNWRKINAHN----NGNHTFKMALNQFSDMSFAEIKHKYLWSEPQ---------- 100

  Fly   147 ESSKEERDKVNCQAAWEKFLIDFGAQYKNANETEKRRNVFCANWRAIVEHNVQYEKWAEPFKRDI 211
                      ||.|....:|...| .|..:.:..|:.|                  :..|.|
Human   101 ----------NCSATKSNYLRGTG-PYPPSVDWRKKGN------------------FVSPVK--- 133

  Fly   212 NQ------WTDHT---IEERSSPAP----EIRKEEATTSTSEIDNDNIICQ-----PAWEKFLID 258
            ||      ||..|   :|...:.|.    .:.:::......:.:|..  ||     .|:|..|.:
Human   134 NQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG--CQGGLPSQAFEYILYN 196

  Fly   259 FKPSYQDDTETEKRRNVFCDNFKSIHKHNVQFDLGN-ISFKKGINQWSDLTV--EEWKNKQRPAF 320
             |....:||...:.::.:|           :|..|. |.|.|.:   :::|:  ||...:....:
Human   197 -KGIMGEDTYPYQGKDGYC-----------KFQPGKAIGFVKDV---ANITIYDEEAMVEAVALY 246

  Fly   321 NPEFSKVEAT 330
            ||.....|.|
Human   247 NPVSFAFEVT 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6357	NP_610907.1	Inhibitor_I29	72..132	CDD:285458	17/49 (35%)
		Inhibitor_I29	162..221	CDD:214853	12/67 (18%)
		Inhibitor_I29	252..311	CDD:214853	12/61 (20%)
		Inhibitor_I29	347..406	CDD:214853
CTSH	NP_004381.2	Inhibitor_I29	35..90	CDD:285458	16/43 (37%)
CTSH	NP_004381.2	Peptidase_C1	117..332	CDD:278538	33/178 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12411
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910