DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6347 and ctsf

DIOPT Version :9

Sequence 1:	NP_610906.1	Gene:	CG6347 / 36531	FlyBaseID:	FBgn0033874	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001071036.1	Gene:	ctsf / 565588	ZFINID:	ZDB-GENE-030131-9831	Length:	473	Species:	Danio rerio

Alignment Length:	333	Identity:	102/333 - (30%)
Similarity:	171/333 - (51%)	Gaps:	53/333 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 FDDFLRQTGKVYSDEE------RVYRESIFAAKMSLITLSNKNADNGVSGFRLGVNTLADMTRKE 96
            |.:|:....:.||.:|      |::::::..|: :|.:|...:|:.|::.|       :|:|.
Zfish   175 FKNFMITYNRTYSSQEEAEKRLRIFQQNMKTAQ-TLQSLEQGSAEYGITKF-------SDLTE-- 229

  Fly    97 IATLLGSKISEFGERYTNGHINFVTARN------PASANLPEMFDWREKGGVTPPGFQGVGCGAC 155
                     .||...|.|..::..:.:.      ||||..|:.:|||:.|.|:|...||: ||:|
Zfish   230 ---------DEFRMMYLNPMLSQWSLKKEMKPAIPASAPAPDTWDWRDHGAVSPVKNQGM-CGSC 284

  Fly   156 WSFATTGALEGHLFRRTGVLASLSQQNLVDCADDYGNMGCDGGFQEYGFEYIRD-HGVTLANKYP 219
            |:|:.||.:||..|::||.|.|||:|.||||  |..:..|.||.....:|.|.: .|:.....|.
Zfish   285 WAFSVTGNIEGQWFKKTGQLLSLSEQELVDC--DKLDQACGGGLPSNAYEAIENLGGLETETDYS 347

  Fly   220 YTQTEMQCRQNETAGRPPRESLVKIRDYATIT---PGDEEKMKEVIATLGPLACSMNADTISFEQ 281
            ||..:..|  :.:.|        |:..|...:   |.||:::...:|..||::.::||..:.|
Zfish   348 YTGHKQSC--DFSTG--------KVAAYINSSVELPKDEKEIAAFLAENGPVSAALNAFAMQF-- 400

  Fly   282 YSGGIYEDEE--CNQGELNHSVTVVGYGTENGRDYWIIKNSYSQNWGEGGFMRILRNAGGFCGIA 344
            |..|:....:  ||...::|:|.:||:|..||..:|.||||:.:::||.|:..:.|.: |.|||.
Zfish   401 YRKGVSHPLKIFCNPWMIDHAVLLVGFGQRNGVPFWAIKNSWGEDYGEQGYYYLYRGS-GLCGIH 464

  Fly   345 SECSYPIL 352
            ..||..|:
Zfish   465 KMCSSAIV 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6347	NP_610906.1	Inhibitor_I29	38..97	CDD:285458	14/64 (22%)
CG6347	NP_610906.1	Peptidase_C1A	131..350	CDD:239068	79/224 (35%)
ctsf	NP_001071036.1	CY	34..144	CDD:214484
		PTZ00203	143..472	CDD:185513	101/331 (31%)
		Inhibitor_I29	175..231	CDD:214853	14/74 (19%)
		Peptidase_C1	262..471	CDD:278538	78/224 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820