DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6347 and ctsz

DIOPT Version :9

Sequence 1:	NP_610906.1	Gene:	CG6347 / 36531	FlyBaseID:	FBgn0033874	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001006043.1	Gene:	ctsz / 450022	ZFINID:	ZDB-GENE-041010-139	Length:	301	Species:	Danio rerio

Alignment Length:	255	Identity:	80/255 - (31%)
Similarity:	123/255 - (48%)	Gaps:	44/255 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 LPEMFDWREKGGVT---------PPGFQGVGCGACWSFATTGALEGHL-FRRTGVLAS--LSQQN 182
            ||:.:|||...||.         .|.:    ||:||:..:|.||...: .:|.....|  ||.||
Zfish    54 LPKEWDWRNIKGVNYVSTTRNQHIPQY----CGSCWAHGSTSALADRINIKRKAAWPSAYLSVQN 114

  Fly   183 LVDCADDYGNMG-CDGGFQEYGFEYIRDHGVTLANKYPYTQTEMQCRQNETAGR---------PP 237
            ::||    |:.| |.||.....:||..:.|:.......|...:..|:.....|.         ..
Zfish   115 VIDC----GDAGSCSGGDHSGVWEYAHNKGIPDETCNNYQAKDQDCKPFNQCGTCTTFGVCNIVK 175

  Fly   238 RESLVKIRDYATITPGDEEKMKEVIATLGPLACSMNADTISFEQYSGGIYEDEECNQGELNHSVT 302
            ..:|.|:.||.:.:..|  |||..|.:.||::|.:.| |...:.|:||:| .|...:..:||.|:
Zfish   176 NFTLWKVGDYGSASGLD--KMKAEIYSGGPISCGIMA-TDKLDAYTGGLY-SEYVQEPYINHIVS 236

  Fly   303 VVGYGT-ENGRDYWIIKNSYSQNWGEGGFMRILRNA--GGF-----CGIASECSY--PIL 352
            |.|:|. |||.::|:::||:.:.|||.|::||:.:|  ||.     ..|..:|.|  |||
Zfish   237 VAGWGVDENGVEFWVVRNSWGEPWGEKGWLRIVTSAYKGGSGSQYNLAIEEDCMYGDPIL 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6347	NP_610906.1	Inhibitor_I29	38..97	CDD:285458
CG6347	NP_610906.1	Peptidase_C1A	131..350	CDD:239068	76/250 (30%)
ctsz	NP_001006043.1	Peptidase_C1A_CathepsinX	54..295	CDD:239149	77/252 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820