DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6347 and ctsba

DIOPT Version :9

Sequence 1:	NP_610906.1	Gene:	CG6347 / 36531	FlyBaseID:	FBgn0033874	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_998501.1	Gene:	ctsba / 406645	ZFINID:	ZDB-GENE-040426-2650	Length:	330	Species:	Danio rerio

Alignment Length:	274	Identity:	72/274 - (26%)
Similarity:	112/274 - (40%)	Gaps:	60/274 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 RYTNGHINFVTARNPASANLPEMFDWREKGGVTPP----GFQGVGCGACWSFATTGALEGH--LF 169
            :||.|            ..||:.||.||:....|.    ..|| .||:||:|....|:...  :.
Zfish    72 QYTEG------------LKLPKNFDAREQWPNCPTLKEIRDQG-SCGSCWAFGAAEAISDRVCIH 123

  Fly   170 RRTGVLASLSQQNLVDCADDYGNMGCDGGFQEYGFEYIRDHGVTLANKY-------PYTQTEMQC 227
            ....|...:|.|:|:.|.|..| |||:||:....:::....|:.....|       |||..  .|
Zfish   124 SDAKVSVEISSQDLLTCCDSCG-MGCNGGYPSAAWDFWATEGLVTGGLYNSHIGCRPYTIE--PC 185

  Fly   228 RQNETAGRPP-------------------RESLVKIRDYATITPGDEEKMKEVIATL---GPLAC 270
            ..:....|||                   ..|..:.:.:...:.........::|.|   ||:.
Zfish   186 EHHVNGSRPPCSGEGGDTPNCDMKCEPGYSPSYKQDKHFGKTSYSVPSNQNSIMAELFKNGPVE- 249

  Fly   271 SMNADTI--SFEQYSGGIYEDEECNQ-GELNHSVTVVGYGTENGRDYWIIKNSYSQNWGEGGFMR 332
              .|.|:  .|..|..|:|:....:. |  .|::.::|:|.|||..||:..||::.:||:.|:.:
Zfish   250 --GAFTVYEDFLLYKSGVYQHMSGSPVG--GHAIKILGWGEENGVPYWLAANSWNTDWGDNGYFK 310

  Fly   333 ILRNAGGFCGIASE 346
            |||.. ..|||.||
Zfish   311 ILRGE-DHCGIESE 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6347	NP_610906.1	Inhibitor_I29	38..97	CDD:285458
CG6347	NP_610906.1	Peptidase_C1A	131..350	CDD:239068	68/254 (27%)
ctsba	NP_998501.1	Propeptide_C1	25..64	CDD:285358
ctsba	NP_998501.1	Peptidase_C1A_CathepsinB	80..327	CDD:239111	68/254 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820