DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6347 and Ctsc

DIOPT Version :9

Sequence 1:	NP_610906.1	Gene:	CG6347 / 36531	FlyBaseID:	FBgn0033874	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_058793.1	Gene:	Ctsc / 25423	RGDID:	2445	Length:	462	Species:	Rattus norvegicus

Alignment Length:	313	Identity:	96/313 - (30%)
Similarity:	130/313 - (41%)	Gaps:	85/313 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LGSKISEFGER-YTNGHINFVTARN------------------------------------PAS- 127
            ||....::.|| |::.| |||.|.|                                    ||.
  Rat   156 LGGLQEKYSERLYSHNH-NFVKAINSVQKSWTATTYEEYEKLSIRDLIRRSGHSGRILRPKPAPI 219

  Fly   128 --------ANLPEMFDWREKGGV--TPPGFQGVGCGACWSFATTGALEGHLFRRTGVLAS----- 177
                    .:|||.:|||...|:  ..|......||:|:|||:.|.||.    |..:|.:
  Rat   220 TDEIQQQILSLPESWDWRNVRGINFVSPVRNQESCGSCYSFASLGMLEA----RIRILTNNSQTP 280

  Fly   178 -LSQQNLVDCADDYGNMGCDGGFQE-YGFEYIRDHGVTLANKYPYTQTEMQCRQNETAGRPPRES 240
             ||.|.:|.|: .|. .||||||.. ...:|.:|.||...|.:|||.|:..|:        |:|:
  Rat   281 ILSPQEVVSCS-PYA-QGCDGGFPYLIAGKYAQDFGVVEENCFPYTATDAPCK--------PKEN 335

  Fly   241 LVKIRDYATITPG------DEEKMKEVIATLGPLACSMNADTISFEQYSGGIYE----DEECNQG 295
            .::.........|      :|..||..:...||:|.:..... .|..|..|||.    .:..|..
  Rat   336 CLRYYSSEYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHD-DFLHYHSGIYHHTGLSDPFNPF 399

  Fly   296 EL-NHSVTVVGYGTE--NGRDYWIIKNSYSQNWGEGGFMRILRNAGGFCGIAS 345
            || ||:|.:||||.:  .|.||||:|||:...|||.|:.||.|.... |.|.|
  Rat   400 ELTNHAVLLVGYGKDPVTGLDYWIVKNSWGSQWGESGYFRIRRGTDE-CAIES 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6347	NP_610906.1	Inhibitor_I29	38..97	CDD:285458
CG6347	NP_610906.1	Peptidase_C1A	131..350	CDD:239068	82/237 (35%)
Ctsc	NP_058793.1	CathepsinC_exc	25..138	CDD:400909
		Pox_I6	168..>204	CDD:333259	7/36 (19%)
		Peptidase_C1A_CathepsinC	230..459	CDD:239112	83/238 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820