DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6347 and cpr-8

DIOPT Version :9

Sequence 1:	NP_610906.1	Gene:	CG6347 / 36531	FlyBaseID:	FBgn0033874	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_503384.1	Gene:	cpr-8 / 178613	WormBaseID:	WBGene00021070	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	289	Identity:	75/289 - (25%)
Similarity:	114/289 - (39%)	Gaps:	57/289 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 ATLLGSKISEFGERYTNGHIN---FVTARNPASANLPEMFDWREKGGVTPPGFQGVGCGACWSFA 159
            |..:|.||..||....|..::   ....|.|...::|::.|..|             |...|:||
Worm    57 AATIGFKIQNFGVSQANSDLSPSFDARERWPECMSIPQINDISE-------------CKTSWAFA 108

  Fly   160 TTGALEGHLFRRTGVLAS--LSQQNLVDCADDYGNM--GCDGGFQEYGFEYIRDHGVTLANKY-- 218
            ...::...|...:|...:  ||.:.|:.|.....:.  ||:||.....::||:.||:.....|
Worm   109 AAESMSDRLCINSGGFKNTILSAEELLSCCTGMFSCGEGCEGGNPFKAWQYIQKHGIPTGGSYES 173

  Fly   219 -----PYT----------QTEMQCRQNETAGRPPRE-----------SLVKIRDYATIT---PGD 254
                 ||:          .|...| .|.|:..|..|           .:.|.|.|....   |..
Worm   174 QFGCKPYSIPPCGKTVGNVTYPAC-TNTTSPTPSCEKKCTSRIGYPIDIDKDRHYGVSVDQLPNS 237

  Fly   255 EEKMKEVIATLGPLACSMNADTISFEQYSGGIYEDEECN-QGELNHSVTVVGYGTENGRDYWIIK 318
            :.:::..:...||:..:..... .|.||:.|||.....| ||.|  ||.::|:|...|..||:..
Worm   238 QIEIQSDVMLNGPIQATFEVYD-DFLQYTTGIYVHLTGNKQGHL--SVRIIGWGVWQGVPYWLCA 299

  Fly   319 NSYSQNWGEGGFMRILRNAGGFCGIASEC 347
            ||:.:.|||.|..|:||.... ||:.|.|
Worm   300 NSWGRQWGENGTFRVLRGTNE-CGLESNC 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6347	NP_610906.1	Inhibitor_I29	38..97	CDD:285458
CG6347	NP_610906.1	Peptidase_C1A	131..350	CDD:239068	66/253 (26%)
cpr-8	NP_503384.1	Propeptide_C1	24..>40	CDD:369701
cpr-8	NP_503384.1	Peptidase_C1A_CathepsinB	79..330	CDD:239111	68/267 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820