Protein Alignment CtsL2 and Y65B4A.2

DIOPT Version :10

• Sequence 1: NP_610906.1
• Gene: CtsL2 / 36531
• FlyBaseID: FBgn0033874
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_001293246.1
• Gene: Y65B4A.2 / 171655
• WormBaseID: WBGene00022026
• Length: 448
• Species: Caenorhabditis elegans
• Alignment Length: 419
• Identity: 86/419 - (20%)
• Similarity: 157/419 - (37%)
• Gaps: 125/419 - (29%)

  Fly     2 RMCSTMWLQMTLGLALLGAV--SLQQLQSF-PKLCDVQNFDDFLRQTGKVYSDEERVYRESIFAA 63
            ::.:|:...:.|.||:||.|  |....:.: ....|.::.|::||:..:..:|..    |:.:.|
 Worm    51 QVAATIASVILLLLAVLGLVYGSFYLYRRYVTDANDKRDNDEYLRKLVRQVNDSP----ETTWKA 111

  Fly    64 KMSLITLSNKNADNGVSGFRLGVNTLADMTRKEIATLLGSKISEFGERY--------TNGHINFV 120
            |.:...:.|::     .||:        .||.:.|      :.|:.|:.        ...|::
 Worm   112 KFNKFGVKNRS-----YGFK--------YTRNQTA------VEEYVEQIRKFFESDAMKRHLD-- 155

  Fly   121 TARNPASANLPEMFDWREKGGVTP-----PGFQGVGCGACWSFATTG-ALEGHLFRRTGVLAS-L 178
            ...|..|:::|:.||.|:|....|     |. || |||:|::.|..| |.:.......|...| |
 Worm   156 ELENFNSSDVPKNFDARQKWPNCPSISNVPN-QG-GCGSCFAVAAAGVASDRACIHSNGTFKSLL 218

  Fly   179 SQQNLVDCADDYGNMGCDGGFQEYGFEYIRDHGVTLANK---YPYT-----------QTEMQCRQ 229
            |:::::.|....||  |.||.......|..:.|:....:   .||:           .|..:..:
 Worm   219 SEEDIIGCCSVCGN--CYGGDPLKALTYWVNQGLVTGGRDGCRPYSFDLSCGVPCSPATFFEAEE 281

  Fly   230 NETAGRP------------------------PRESLVKIRDYATITPGDEEK------------- 257
            ..|..:.                        ||.        .|::|..:|:
 Worm   282 KRTCMKRCQNIYYQQKYEEDKHFATFAYSMYPRS--------MTVSPDGKERVKVPTIIGHFNDK 338

  Fly   258 -------------MKEVIATLGPLACSMNADTISFEQYSGGIYE----DEECNQGELNHSVTVVG 305
                         :|:.|...||...:..... .|..||.|::.    |...::....|.|.::|
 Worm   339 KTEKLNVTEYRDIIKKEILLYGPTTMAFPVPE-EFLHYSSGVFRPYPTDGFDDRIVYWHVVRLIG 402

  Fly   306 YG-TENGRDYWIIKNSYSQNWGEGGFMRI 333
            :| :::|..||:..||:..:||:.|..:|
 Worm   403 WGESDDGTHYWLAVNSFGNHWGDNGLFKI 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL2	NP_610906.1	Inhibitor_I29	38..97	CDD:462410	12/58 (21%)
		Peptidase_C1A	131..350	CDD:239068	59/279 (21%)
Y65B4A.2	NP_001293246.1	Peptidase_C1A_CathepsinB	166..444	CDD:239111	59/279 (21%)