DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6347 and CTSZ

DIOPT Version :9

Sequence 1:	NP_610906.1	Gene:	CG6347 / 36531	FlyBaseID:	FBgn0033874	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001327.2	Gene:	CTSZ / 1522	HGNCID:	2547	Length:	303	Species:	Homo sapiens

Alignment Length:	256	Identity:	80/256 - (31%)
Similarity:	130/256 - (50%)	Gaps:	43/256 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 ANLPEMFDWREKGGVT---------PPGFQGVGCGACWSFATTGALEGHL-FRRTGVLAS--LSQ 180
            |:||:.:|||...||.         .|.:    ||:||:.|:|.|:...: .:|.|...|  ||.
Human    60 ADLPKSWDWRNVDGVNYASITRNQHIPQY----CGSCWAHASTSAMADRINIKRKGAWPSTLLSV 120

  Fly   181 QNLVDCADDYGNMG-CDGGFQEYGFEYIRDHGV--TLANKYPYTQTEMQ-------CRQNETAGR 235
            ||::||    ||.| |:||.....::|...||:  ...|.|.....|..       |.:.:....
Human   121 QNVIDC----GNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHA 181

  Fly   236 PPRESLVKIRDYATITPGDEEKMKEVIATLGPLACSMNADTISFEQYSGGIYEDEECNQGELNHS 300
            ....:|.::.||.::: |.|:.|.|:.|. ||::|.:.| |.....|:||||.:.: :...:||.
Human   182 IRNYTLWRVGDYGSLS-GREKMMAEIYAN-GPISCGIMA-TERLANYTGGIYAEYQ-DTTYINHV 242

  Fly   301 VTVVGYGTENGRDYWIIKNSYSQNWGEGGFMRILRNA-----GGFCGIASE--CSY--PIL 352
            |:|.|:|..:|.:|||::||:.:.|||.|::||:.:.     |....:|.|  |::  ||:
Human   243 VSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6347	NP_610906.1	Inhibitor_I29	38..97	CDD:285458
CG6347	NP_610906.1	Peptidase_C1A	131..350	CDD:239068	76/249 (31%)
CTSZ	NP_001327.2	Peptidase_C1A_CathepsinX	62..302	CDD:239149	77/251 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3812
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770