Protein Alignment CtsL2 and CTSS

DIOPT Version :10

• Sequence 1: NP_610906.1
• Gene: CtsL2 / 36531
• FlyBaseID: FBgn0033874
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_004070.3
• Gene: CTSS / 1520
• HGNCID: 2545
• Length: 331
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 122/309 - (39%)
• Similarity: 174/309 - (56%)
• Gaps: 19/309 - (6%)

  Fly    46 GKVYSDE-ERVYRESIFAAKMSLITLSNKNADNGVSGFRLGVNTLADMTRKEIATLLGS-KISEF 108
            ||.|.:: |...|..|:...:..:.|.|.....|:..:.||:|.|.|||.:|:.:|:.| ::...
Human    36 GKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQ 100

  Fly   109 GERYTNGHINFVTARNPASANLPEMFDWREKGGVTPPGFQGVGCGACWSFATTGALEGHLFRRTG 173
            .:|      |.....|| :..||:..||||||.||...:|| .|||||:|:..||||..|..:||
Human   101 WQR------NITYKSNP-NRILPDSVDWREKGCVTEVKYQG-SCGACWAFSAVGALEAQLKLKTG 157

  Fly   174 VLASLSQQNLVDCA-DDYGNMGCDGGFQEYGFEYIRDH-GVTLANKYPYTQTEMQCRQNETAGRP 236
            .|.|||.||||||: :.|||.||:|||....|:||.|: |:.....|||...:.:|:.:.
Human   158 KLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDS----- 217

  Fly   237 PRESLVKIRDYATITPGDEEKMKEVIATLGPLACSMNADTISFEQYSGGIYEDEECNQGELNHSV 301
             :........|..:..|.|:.:||.:|..||::..::|...||..|..|:|.:..|.| .:||.|
Human   218 -KYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQ-NVNHGV 280

  Fly   302 TVVGYGTENGRDYWIIKNSYSQNWGEGGFMRILRNAGGFCGIASECSYP 350
            .|||||..||::||::|||:..|:||.|::|:.||.|..|||||..|||
Human   281 LVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYP 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL2	NP_610906.1	Inhibitor_I29	38..97	CDD:462410	16/51 (31%)
		Peptidase_C1A	131..350	CDD:239068	96/220 (44%)
CTSS	NP_004070.3	Inhibitor_I29	28..87	CDD:214853	16/50 (32%)
		Peptidase_C1	115..329	CDD:425470	97/221 (44%)