DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6347 and CTSK

DIOPT Version :9

Sequence 1:	NP_610906.1	Gene:	CG6347 / 36531	FlyBaseID:	FBgn0033874	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_000387.1	Gene:	CTSK / 1513	HGNCID:	2536	Length:	329	Species:	Homo sapiens

Alignment Length:	308	Identity:	116/308 - (37%)
Similarity:	172/308 - (55%)	Gaps:	19/308 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KVYSDE-ERVYRESIFAAKMSLITLSNKNADNGVSGFRLGVNTLADMTRKEIA-TLLGSKISEFG 109
            |.|::: :.:.|..|:...:..|::.|..|..||..:.|.:|.|.|||.:|:. .:.|.|:....
Human    35 KQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSH 99

  Fly   110 ERYTNGHINFVTARNPA-SANLPEMFDWREKGGVTPPGFQGVGCGACWSFATTGALEGHLFRRTG 173
            .|..:      |...|. ....|:..|:|:||.|||...|| .||:||:|::.|||||.|.::||
Human   100 SRSND------TLYIPEWEGRAPDSVDYRKKGYVTPVKNQG-QCGSCWAFSSVGALEGQLKKKTG 157

  Fly   174 VLASLSQQNLVDCADDYGNMGCDGGFQEYGFEYI-RDHGVTLANKYPYTQTEMQCRQNETAGRPP 237
            .|.:||.||||||..:  |.||.||:....|:|: ::.|:...:.|||...|..|..|      |
Human   158 KLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYN------P 214

  Fly   238 RESLVKIRDYATITPGDEEKMKEVIATLGPLACSMNADTISFEQYSGGIYEDEECNQGELNHSVT 302
            .....|.|.|..|..|:|:.:|..:|.:||::.:::|...||:.||.|:|.||.||...|||:|.
Human   215 TGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVL 279

  Fly   303 VVGYGTENGRDYWIIKNSYSQNWGEGGFMRILRNAGGFCGIASECSYP 350
            .||||.:.|..:||||||:.:|||..|::.:.||....||||:..|:|
Human   280 AVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6347	NP_610906.1	Inhibitor_I29	38..97	CDD:285458	15/50 (30%)
CG6347	NP_610906.1	Peptidase_C1A	131..350	CDD:239068	94/219 (43%)
CTSK	NP_000387.1	Inhibitor_I29	26..85	CDD:214853	15/49 (31%)
CTSK	NP_000387.1	Peptidase_C1	115..327	CDD:306594	94/220 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53545
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830