DRSC/TRiP Functional Genomics Resources

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Protein Alignment CtsL2 and CTSB

DIOPT Version :10

Sequence 1:NP_610906.1 Gene:CtsL2 / 36531 FlyBaseID:FBgn0033874 Length:352 Species:Drosophila melanogaster
Sequence 2:NP_001899.1 Gene:CTSB / 1508 HGNCID:2527 Length:339 Species:Homo sapiens


Alignment Length:256 Identity:72/256 - (28%)
Similarity:111/256 - (43%) Gaps:50/256 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 LPEMFDWREKGGVTPP----GFQGVGCGACWSFATTGALEGHLFRRTG--VLASLSQQNLVDCAD 188
            ||..||.||:....|.    ..|| .||:||:|....|:...:...|.  |...:|.::|:.|..
Human    80 LPASFDAREQWPQCPTIKEIRDQG-SCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCG 143

  Fly   189 DYGNMGCDGGFQEYGFEYIRDHGVTLANKY-------PYTQTEMQCRQNETAGRPP------RES 240
            .....||:||:....:.:....|:.....|       ||:..  .|..:....|||      ...
Human   144 SMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIP--PCEHHVNGSRPPCTGEGDTPK 206

  Fly   241 LVKIRD--------------YATITPGDEEK--MKEVIATLGPL--ACSMNADTISFEQYSGGIY 287
            ..||.:              |.:.:..:.||  |.|:... ||:  |.|:.:|   |..|..|:|
Human   207 CSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKN-GPVEGAFSVYSD---FLLYKSGVY 267

  Fly   288 EDEECNQGEL--NHSVTVVGYGTENGRDYWIIKNSYSQNWGEGGFMRILRNAGGFCGIASE 346
            :..   .||:  .|::.::|:|.|||..||::.||::.:||:.||.:|||.. ..|||.||
Human   268 QHV---TGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQ-DHCGIESE 324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CtsL2NP_610906.1 Inhibitor_I29 38..97 CDD:462410
Peptidase_C1A 131..350 CDD:239068 71/255 (28%)
CTSBNP_001899.1 Propeptide_C1 26..65 CDD:462365
Peptidase_C1A_CathepsinB 81..328 CDD:239111 71/255 (28%)
Blue background indicates that the domain is not in the aligned region.

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