Protein Alignment CtsL2 and Ctsb

DIOPT Version :10

• Sequence 1: NP_610906.1
• Gene: CtsL2 / 36531
• FlyBaseID: FBgn0033874
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_031824.1
• Gene: Ctsb / 13030
• MGIID: 88561
• Length: 339
• Species: Mus musculus
• Alignment Length: 385
• Identity: 94/385 - (24%)
• Similarity: 140/385 - (36%)
• Gaps: 106/385 - (27%)

  Fly     7 MWLQMTLGLALLGAVSLQQLQSFPKLCDVQNFDDFLRQTGKVYSDEERVYRESIFAAKMSLITLS 71
            ||..:.|...||...|.....||..|.|                               .||...
Mouse     1 MWWSLILLSCLLALTSAHDKPSFHPLSD-------------------------------DLINYI 34

  Fly    72 NKNADNGVSGFRLGVNTLADMTRKEIATLLGS-KIS---EFGERYTNGHINFVTARNPASANLPE 132
            ||......:| |...|......:|...|:||. |:.   .|||                ..:|||
Mouse    35 NKQNTTWQAG-RNFYNVDISYLKKLCGTVLGGPKLPGRVAFGE----------------DIDLPE 82

  Fly   133 MFDWREK-------GGVTPPGFQGVGCGACWSFATTGALEGHLFRRTG--VLASLSQQNLVDCAD 188
            .||.||:       |.:...|    .||:||:|....|:.......|.  |...:|.::|:.|..
Mouse    83 TFDAREQWSNCPTIGQIRDQG----SCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCCG 143

  Fly   189 DYGNMGCDGGFQEYGFEYIRDHGVTLANKY-------PYTQTEMQCRQNETAGRPP--------- 237
            .....||:||:....:.:....|:.....|       |||..  .|..:....|||
Mouse   144 IQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIP--PCEHHVNGSRPPCTGEGDTPR 206

  Fly   238 ---------RESLVKIRDYATITPGDEEKMKEVIATL---GPLACSMNADTI--SFEQYSGGIYE 288
                     ..|..:.:.:...:......:||::|.:   ||:.   .|.|:  .|..|..|:|:
Mouse   207 CNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVE---GAFTVFSDFLTYKSGVYK 268

  Fly   289 DEECNQGEL--NHSVTVVGYGTENGRDYWIIKNSYSQNWGEGGFMRILRNAGGFCGIASE 346
            .|   .|::  .|::.::|:|.|||..||:..||::.:||:.||.:|||.. ..|||.||
Mouse   269 HE---AGDMMGGHAIRILGWGVENGVPYWLAANSWNLDWGDNGFFKILRGE-NHCGIESE 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CtsL2	NP_610906.1	Inhibitor_I29	38..97	CDD:462410	8/58 (14%)
		Peptidase_C1A	131..350	CDD:239068	68/257 (26%)
Ctsb	NP_031824.1	Propeptide_C1	26..65	CDD:462365	12/70 (17%)
		Peptidase_C1A_CathepsinB	81..328	CDD:239111	68/257 (26%)