DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6337 and ctsf

DIOPT Version :9

Sequence 1:	NP_001286395.1	Gene:	CG6337 / 36530	FlyBaseID:	FBgn0033873	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001071036.1	Gene:	ctsf / 565588	ZFINID:	ZDB-GENE-030131-9831	Length:	473	Species:	Danio rerio

Alignment Length:	313	Identity:	80/313 - (25%)
Similarity:	131/313 - (41%)	Gaps:	38/313 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LVDFQTYEDNFNKTYASTSARNFANYYFIYNRN-QVAQHNAQADRNRTTYREAVNQFSDIRLIQF 88
            |..|:.:...:|:||:|.....  ....|:.:| :.||.....::....|  .:.:|||:...:|
Zfish   172 LTMFKNFMITYNRTYSSQEEAE--KRLRIFQQNMKTAQTLQSLEQGSAEY--GITKFSDLTEDEF 232

  Fly    89 AALLPKAVNTVTSAAS-----DP--PASQAASASFDIITDFGLTVAVEDQGVNCSSSWAYATAKA 146
            ..:.   :|.:.|..|     .|  |||..|..::| ..|.|....|::||: |.|.||::....
Zfish   233 RMMY---LNPMLSQWSLKKEMKPAIPASAPAPDTWD-WRDHGAVSPVKNQGM-CGSCWAFSVTGN 292

  Fly   147 VEIMNAVQTANPLPSSLSAQQLLDCAGMGTGCSTQTPLAALNYLTQLTDAYLYPEVDYPNNNSLK 211
            :|.....:|...|  |||.|:|:||..:...|....|..|...:..|  ..|..|.||......:
Zfish   293 IEGQWFKKTGQLL--SLSEQELVDCDKLDQACGGGLPSNAYEAIENL--GGLETETDYSYTGHKQ 353

  Fly   212 TPGMCQPPSSVSVGVKLAGY---STVADNDDAAVMRYVSNGFPVIVEYNPATFGFMQYSSGVYVQ 273
            :   |    ..|.| |:|.|   |.....|:..:..:::...||....|  .|....|..|| ..
Zfish   354 S---C----DFSTG-KVAAYINSSVELPKDEKEIAAFLAENGPVSAALN--AFAMQFYRKGV-SH 407

  Fly   274 ETRALTNP-KSSQFLVVVGYDHDVDSNLDYWRCLNSFGDTWGEEGYIRIVRRS 325
            ..:...|| .....:::||:..  .:.:.:|...||:|:.:||:||..:.|.|
Zfish   408 PLKIFCNPWMIDHAVLLVGFGQ--RNGVPFWAIKNSWGEDYGEQGYYYLYRGS 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6337	NP_001286395.1	Inhibitor_I29	28..88	CDD:285458	13/60 (22%)
CG6337	NP_001286395.1	Peptidase_C1A	114..336	CDD:239068	57/216 (26%)
ctsf	NP_001071036.1	CY	34..144	CDD:214484
		PTZ00203	143..472	CDD:185513	80/313 (26%)
		Inhibitor_I29	175..231	CDD:214853	13/59 (22%)
		Peptidase_C1	262..471	CDD:278538	57/216 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900