DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6337 and ctsc

DIOPT Version :9

Sequence 1:	NP_001286395.1	Gene:	CG6337 / 36530	FlyBaseID:	FBgn0033873	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_999887.1	Gene:	ctsc / 368704	ZFINID:	ZDB-GENE-030619-9	Length:	455	Species:	Danio rerio

Alignment Length:	255	Identity:	70/255 - (27%)
Similarity:	104/255 - (40%)	Gaps:	33/255 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 AALLPKAVNTVTSAASDPPASQAASA-----SFDIITDFGLTVAVEDQGVNCSSSWAYATAKAVE 148
            |:.:|:.|..||.||.    |:|||.     .:..:........|.:| ..|.|.:::||...:|
Zfish   202 ASRIPRRVRPVTVAAD----SKAASGLPQHWDWRNVNGVNFVSPVRNQ-AQCGSCYSFATMGMLE 261

  Fly   149 IMNAVQTANPLPSSLSAQQLLDCAGMGTGCSTQTPLAALNYLTQL----TDAYLYPEVDYPNNNS 209
            ....:||.|......|.||::.|:....||....|.....|:...    .|.:.|...|.|.|
Zfish   262 ARVRIQTNNTQQPVFSPQQVVSCSQYSQGCDGGFPYLIGKYIQDFGIVEEDCFPYTGSDSPCN-- 324

  Fly   210 LKTPGMCQPPSSVS---VGVKLAGYSTVADNDDAAVMRYVSNG-FPVIVEYNPATFGFMQYSSGV 270
              .|..|....:..   ||....|.|     :.|.::..|.|| ..|.:|..|   .||.|..|:
Zfish   325 --LPAKCTKYYASDYHYVGGFYGGCS-----ESAMMLELVKNGPMGVALEVYP---DFMNYKEGI 379

  Fly   271 YVQE-TRALTNP--KSSQFLVVVGYDHDVDSNLDYWRCLNSFGDTWGEEGYIRIVRRSNQ 327
            |... .|...||  .::..:::|||.....:...||...||:|..|||.|:.||.|.:::
Zfish   380 YHHTGLRDANNPFELTNHAVLLVGYGQCHKTGEKYWIVKNSWGSGWGENGFFRIRRGTDE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6337	NP_001286395.1	Inhibitor_I29	28..88	CDD:285458
CG6337	NP_001286395.1	Peptidase_C1A	114..336	CDD:239068	59/230 (26%)
ctsc	NP_999887.1	CathepsinC_exc	20..132	CDD:285926
ctsc	NP_999887.1	Peptidase_C1A_CathepsinC	224..452	CDD:239112	59/229 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275401at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010