DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6337 and CtsB1

DIOPT Version :9

Sequence 1:	NP_001286395.1	Gene:	CG6337 / 36530	FlyBaseID:	FBgn0033873	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001259536.2	Gene:	CtsB1 / 32341	FlyBaseID:	FBgn0030521	Length:	340	Species:	Drosophila melanogaster

Alignment Length:	234	Identity:	53/234 - (22%)
Similarity:	83/234 - (35%)	Gaps:	55/234 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 VEDQGVNCSSSWAYATAKAVEIMNAVQTANPLPSSLSAQQLLDCA-GMGTGCSTQTPLAALNYLT 191
            :.||| :|.|.||:...:|:.....:.:...:....||..|:.|. ..|.||:...|.||.:|.|
  Fly   106 IRDQG-SCGSCWAFGAVEAMSDRVCIHSGGKVNFHFSADDLVSCCHTCGFGCNGGFPGAAWSYWT 169

  Fly   192 QLTDAYLYPEVDYPNNNSLKTPGMCQP--------------PSSVSVG-------VKLAGYSTVA 235
            :.......|   |.:|..      |:|              |.....|       |..:||:.
  Fly   170 RKGIVSGGP---YGSNQG------CRPYEISPCEHHVNGTRPPCAHGGRTPKCSHVCQSGYTV-- 223

  Fly   236 DNDDAAVMRYVSNGFPV----------IVEYNPATFGF------MQYSSGVYVQETRALTNPKSS 284
              |.|....:.|..:.|          |:...|....|      :.|..|||..|.   ......
  Fly   224 --DYAKDKHFGSKSYSVRRNVREIQEEIMTNGPVEGAFTVYEDLILYKDGVYQHEH---GKELGG 283

  Fly   285 QFLVVVGYDHDVDSNLDYWRCLNSFGDTWGEEGYIRIVR 323
            ..:.::|:....:..:.||...||:...||:.|:.||:|
  Fly   284 HAIRILGWGVWGEEKIPYWLIGNSWNTDWGDHGFFRILR 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6337	NP_001286395.1	Inhibitor_I29	28..88	CDD:285458
CG6337	NP_001286395.1	Peptidase_C1A	114..336	CDD:239068	53/234 (23%)
CtsB1	NP_001259536.2	Propeptide_C1	24..64	CDD:285358
CtsB1	NP_001259536.2	Peptidase_C1A_CathepsinB	88..336	CDD:239111	53/234 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810