Protein Alignment CG6337 and CTSB

DIOPT Version :9

• Sequence 1: NP_001286395.1
• Gene: CG6337 / 36530
• FlyBaseID: FBgn0033873
• Length: 340
• Species: Drosophila melanogaster
• Sequence 2: NP_001371643.1
• Gene: CTSB / 1508
• HGNCID: 2527
• Length: 339
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 80/351 - (22%)
• Similarity: 133/351 - (37%)
• Gaps: 77/351 - (21%)

  Fly     6 LCCLLLTID--SGWAFNHGQDLVDFQTYEDNFNKTYASTSARNFANYYFIYNRNQVAQH-NAQAD 67
            |||||:..:  |..:|:...|  :...|.:..|.|:  .:..||.|....|.:...... .....
Human     8 LCCLLVLANARSRPSFHPLSD--ELVNYVNKRNTTW--QAGHNFYNVDMSYLKRLCGTFLGGPKP 68

  Fly    68 RNRTTYREAVNQFSDIRLIQFAALLPKAVNTVTSAASDPPASQAASASFDIITDFGLTVAVE--- 129
            ..|..:.|      |::|                           .||||....:.....::
Human    69 PQRVMFTE------DLKL---------------------------PASFDAREQWPQCPTIKEIR 100

  Fly   130 DQGVNCSSSWAYATAKAVEIMNAVQTANPLPSSLSAQQLLDCAG--MGTGCSTQTPLAALNYLTQ 192
            ||| :|.|.||:...:|:.....:.|...:...:||:.||.|.|  .|.||:...|..|.|:.|:
Human   101 DQG-SCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTR 164

  Fly   193 --LTDAYLY-----------PEVDYPNNNSL----------KTPGMCQPPSSVSVGV-KLAGYST 233
              |....||           |..::..|.|.          |...:|:|..|.:... |..||::
Human   165 KGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNS 229

  Fly   234 VA-DNDDAAVMRYVSNGFPVIVEYNPATFGFMQYSSGVYVQETRALTNPKSSQFLVVVGYDHDVD 297
            .: .|.:..:|..:....||...::..: .|:.|.||||...|..:   .....:.::|:  .|:
Human   230 YSVSNSEKDIMAEIYKNGPVEGAFSVYS-DFLLYKSGVYQHVTGEM---MGGHAIRILGW--GVE 288

  Fly   298 SNLDYWRCLNSFGDTWGEEGYIRIVR 323
            :...||...||:...||:.|:.:|:|
Human   289 NGTPYWLVANSWNTDWGDNGFFKILR 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6337	NP_001286395.1	Inhibitor_I29	28..88	CDD:285458	11/60 (18%)
		Peptidase_C1A	114..336	CDD:239068	61/240 (25%)
CTSB	NP_001371643.1	Propeptide_C1	26..65	CDD:400445	8/42 (19%)
		Peptidase_C1A_CathepsinB	81..328	CDD:239111	61/241 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4870
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810