DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fl(2)d and wtap

DIOPT Version :9

Sequence 1:	NP_523732.2	Gene:	fl(2)d / 36527	FlyBaseID:	FBgn0000662	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_989199.1	Gene:	wtap / 394807	XenbaseID:	XB-GENE-482822	Length:	393	Species:	Xenopus tropicalis

Alignment Length:	456	Identity:	155/456 - (33%)
Similarity:	232/456 - (50%)	Gaps:	79/456 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 HHHPHPHHHHHQEQQQQQQQQQHLQQQQQQQQQQHAAAVAEAVAAAEQRQR-LLEDEIENLKLEQ 122
            :..|.|......|...:...::.|.|:.:|.:..        |.|.|.:.. |..:::..|:..:
Frog     3 NEEPLPKKVRLNESDFKVLPREELLQRWKQFEAY--------VQALENKYTDLNSNDVTGLRESE 59

  Fly   123 VRMAQQCADAQRREKILMRRLANKEQEFQDYVSQIAEYKAQQAPTALALRTALLDPAVNLLFERL 187
            .::.||..|:.|||.||:.|||.||||.|:..:||...|..|.|:...||..::|||:||.|.::
Frog    60 EKLKQQQQDSARRENILVMRLATKEQEMQECTTQIQHLKQVQQPSVAQLRATMVDPAINLFFIKM 124

  Fly   188 KKELKATKAKLEETQNELSAWKFTPDSNTGKRLMAKCRLLYQENEELGKMTSNGRLAKLETELAM 252
            |.||:.||.|||:.|||||||||||||.|||:||||||:|.|||:|||:..|.||:|:||.|||:
Frog   125 KAELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELAL 189

  Fly   253 QKSFSEEVKKSQSELDDFLQELDEDVEGMQSTILFLQQELKTTRDRIQTLEKENAQLKQAIKDEV 317
            ||.:|||:|.||.||:||:.:|||:|||||||||.|||:||.:|.::       :|.:|.|:
Frog   190 QKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKDSRQQL-------SQFQQQIQ--- 244

  Fly   318 VAPAAATNGGTNTTINKLETIHEDACMANNPTNPDCYNGNTNNEQIAAVPQIPLSDDGSN--MNG 380
                  |:|  |.|                |::.....|.|:.:....:...| |:.||:  ...
Frog   245 ------TSG--NRT----------------PSSESKDEGETSGKDCGRILNGP-SNGGSSHQRTH 284

  Fly   381 NAARLARKRNYQEEEALPTVVVVPTPTPVGNNVQEAPPIREVTAPRTLPPKKSKLRGITTRRNSQ 445
            ::..|.|:.:..||:.                  .|.||.|...|.....:.|  ||.::..| |
Frog   285 SSVGLYREGSSTEEDF------------------SASPINEGKLPNHSEERTS--RGGSSYMN-Q 328

  Fly   446 LEEDHQPVTTPVAVPMIVDNAVAGMA--------SEEAAAAAAAVNNSNTGIIPETGVQVGVPVE 502
            |...::.|.:|..    .:|::...:        |:|....:...|.:.:....:.|:...|.|:
Frog   329 LSTGYESVDSPTG----SENSLTHQSNDTDSNHDSQEEKPVSGKGNRTVSSRHLQNGLDSSVNVQ 389

  Fly   503 G 503
            |
Frog   390 G 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fl(2)d	NP_523732.2	Wtap	110..305	CDD:293703	107/194 (55%)
fl(2)d	NP_523732.2	TBPIP	<227..318	CDD:284512	49/90 (54%)
wtap	NP_989199.1	Wtap	1..247	CDD:293703	120/267 (45%)
wtap	NP_989199.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..393		38/204 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3087
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006292
OrthoInspector	1	1.000	-	-		otm48685
Panther	1	1.100	-	-	LDO	PTHR15217
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4571
SonicParanoid	1	1.000	-	-		X6014
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.040