DRSC/TRiP Functional Genomics Resources

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Protein Alignment stj and CACNA2D4

DIOPT Version :9

Sequence 1:NP_001246303.1 Gene:stj / 36526 FlyBaseID:FBgn0261041 Length:1271 Species:Drosophila melanogaster
Sequence 2:NP_758952.4 Gene:CACNA2D4 / 93589 HGNCID:20202 Length:1137 Species:Homo sapiens


Alignment Length:1322 Identity:429/1322 - (32%)
Similarity:636/1322 - (48%) Gaps:298/1322 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MAW------SRLLAWWRLCLGLLSVLVCLAPCVNLQPA---ENINYNLVHSWADKLGMELF---- 52
            :||      |.||  |.|.||           .:|.||   ..|....|..|||..|.:|:    
Human    42 VAWAFVQKTSALL--WLLLLG-----------TSLSPAWGQAKIPLETVKLWADTFGGDLYNTVT 93

  Fly    53 -HLGDFITRR--KEVQESFKDAKVVSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSH 114
             :.|..:.::  |:|:.|.|..:|   :|..:|...::::|.|:..||.||:.:::.||...|:|
Human    94 KYSGSLLLQKKYKDVESSLKIEEV---DGLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNH 155

  Fly   115 Q-NDMADKMFSYYSA---KEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNT 175
            : |:  ..:|.||::   .|..|.|:.|            ::|...:        ||....|.|.
Human   156 EFNE--SLVFDYYNSVLINERDEKGNFV------------ELGAEFL--------LESNAHFSNL 198

  Fly   176 PVNFSVSSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASK 240
            |||.|:|||.:|.||:::.||::..:..||.|:.:|.:|::.||||:||:|||:|||.|.:|..|
Human   199 PVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIK 263

  Fly   241 WRKDV-PVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVN 304
            |..|. .|..:|||.|.||::|||||||||||:|.||||.|.|:.||||.:.|||||||.|||:|
Human   264 WTPDENGVITFDCRNRGWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFIN 328

  Fly   305 IFTFDKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRG 369
            |..::..|..:.|||:..|:||:..|....|..:|....|.:.....||.:||::|::.:.:.:|
Human   329 IIAYNDYVHYIEPCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQG 393

  Fly   370 AQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVH 434
            :.||||||:|.|||.|:...|||.:||   |...|||||||||:||:..|.::|:||.|:|||..
Human   394 SLCNQAIMLISDGAVEDYEPVFEKYNW---PDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQ 455

  Fly   435 LSDTAEVREMVLNYIPVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEY 499
            :|..|:.:|.|:.|:.|::||:|: .|||.:||::.|.   |:||..          .:|..|  
Human   456 ISTLADTQENVMEYLHVLSRPMVI-NHDHDIIWTEAYM---DSKLLS----------SQAQSL-- 504

  Fly   500 WQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKI 564
                                              ..:|||:||::.::..               
Human   505 ----------------------------------TLLTTVAMPVFSKKNE--------------- 520

  Fly   565 NLQVTRIANI-LGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIF-QGYILK 627
                ||...| |||.|:||.:.|:.||...:.|||:||||:.|||||:|.|||.||:: :|..||
Human   521 ----TRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLK 581

  Fly   628 PA--YNSVDMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWMLVKNHFDEMKRVARVKRQY 690
            |.  |||||:.|||..|...          ::|.::||:.||:..|.||...|:.|||..:...|
Human   582 PKPNYNSVDLSEVEWEDQAE----------SLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDY 636

  Fly   691 YWTAIKKTPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSVFSGKRWKIHP------DWL 749
            ::|.|..|||:|.:.....:|            ..|.:..|   ||..|....:||      ||:
Human   637 FFTDISDTPFSLGVVLSRGHG------------EYILLGNT---SVEEGLHDLLHPDLALAGDWI 686

  Fly   750 FCKHSNRTFKTPEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYY 814
            :|    .|...|:...|..||.|.                        ...|.:.|.:.      
Human   687 YC----ITDIDPDHRKLSQLEAMI------------------------RFLTRKDPDLE------ 717

  Fly   815 CDRQLMQALVFDARVTGWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQ-RFGVTVAFLAT 878
            ||.:|::.::|||.||                    :|:......|..|..:: ...|.:|||.|
Human   718 CDEELVREVLFDAVVT--------------------APMEAYWTALALNMSEESEHVVDMAFLGT 762

  Fly   879 HSGLTRWHEFHSNAAEESGVGETF----SQNNTRAIDE--IWYKRAVDQHFVREESFVYSV---- 933
            .:||.|...|   ...|......|    .:.:...:|.  :||::| .:|  ...|||:::    
Human   763 RAGLLRSSLF---VGSEKVSDRKFLTPEDEASVFTLDRFPLWYRQA-SEH--PAGSFVFNLRWAE 821

  Fly   934 -PFDAGESNSEILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLFHNITGNACAVD------- 990
             |..|||   .::||||.||......:||.||..|.|.:...|.:.|...|.....||       
Human   822 GPESAGE---PMVVTASTAVAVTVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSC 883

  Fly   991 ---DKDCYILDNNGYVIISTRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDN 1052
               |.||:::||||:::||.|..|||||.|||:||::.:||...|:.|||:|||||:|..|.:.:
Human   884 EDSDLDCFVIDNNGFILISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHH 948

  Fly  1053 NASSMLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHA 1117
            :|:..|:||:...|...:|||...:.:   ||:|:  |...:.|...::...         .||:
Human   949 SAAQPLVSPISAFLTATRWLLQELVLF---LLEWS--VWGSWYDRGAEAKSV---------FHHS 999

  Fly  1118 RNGNGHGKKDDDHWLRYLTLHRTRLKPCDMKRDLYTLF------NEKDNVVYNMTAHACERPFVV 1176
            ..   |.|:|.             |:|||.:   |.:|      .|.:.:|   ....|::.|||
Human  1000 HK---HKKQDP-------------LQPCDTE---YPVFVYQPAIREANGIV---ECGPCQKVFVV 1042

  Fly  1177 LPIPFSNLILLVIDQLCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHAN 1241
            ..||.|||:|||.|..|  |.|:...|..:..:  :..|.|:.|.:...:..|.||.||.:.|..
Human  1043 QQIPNSNLLLLVTDPTC--DCSIFPPVLQEATE--VKYNASVKCDRMRSQKLRRRPDSCHAFHPE 1103

  Fly  1242 ESGIKLCGKACSVYANLGLLLL 1263
            |:. :.||.|....|:..||||
Human  1104 ENA-QDCGGASDTSASPPLLLL 1124

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stjNP_001246303.1 VWA_N 107..241 CDD:285584 48/137 (35%)
vWA_VGCC_like 253..439 CDD:238740 92/185 (50%)
Cache_1 524..619 CDD:280839 33/95 (35%)
CACNA2D4NP_758952.4 VWA_N 148..264 CDD:285584 48/137 (35%)
vWA_VGCC_like 277..460 CDD:238740 92/185 (50%)
MIDAS-like motif 297..301 2/3 (67%)
Cache_1 487..579 CDD:280839 43/159 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142053
Domainoid 1 1.000 158 1.000 Domainoid score I4113
eggNOG 1 0.900 - - E1_KOG2353
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45864
OrthoDB 1 1.010 - - D110668at33208
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 1 1.000 - - mtm8612
orthoMCL 1 0.900 - - OOG6_103783
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5109
SonicParanoid 1 1.000 - - X365
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.750

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