Protein Alignment stj and CACNA2D4

DIOPT Version :10

• Sequence 1: NP_001246303.1
• Gene: stj / 36526
• FlyBaseID: FBgn0261041
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_758952.4
• Gene: CACNA2D4 / 93589
• HGNCID: 20202
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 1322
• Identity: 429/1322 - (32%)
• Similarity: 636/1322 - (48%)
• Gaps: 298/1322 - (22%)

  Fly     1 MAW------SRLLAWWRLCLGLLSVLVCLAPCVNLQPA---ENINYNLVHSWADKLGMELF---- 52
            :||      |.||  |.|.||           .:|.||   ..|....|..|||..|.:|:
Human    42 VAWAFVQKTSALL--WLLLLG-----------TSLSPAWGQAKIPLETVKLWADTFGGDLYNTVT 93

  Fly    53 -HLGDFITRR--KEVQESFKDAKVVSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSH 114
             :.|..:.::  |:|:.|.|..:|   :|..:|...::::|.|:..||.||:.:::.||...|:|
Human    94 KYSGSLLLQKKYKDVESSLKIEEV---DGLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNH 155

  Fly   115 Q-NDMADKMFSYYSA---KEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNT 175
            : |:  ..:|.||::   .|..|.|:.|            ::|...:        ||....|.|.
Human   156 EFNE--SLVFDYYNSVLINERDEKGNFV------------ELGAEFL--------LESNAHFSNL 198

  Fly   176 PVNFSVSSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASK 240
            |||.|:|||.:|.||:::.||::..:..||.|:.:|.:|::.||||:||:|||:|||.|.:|..|
Human   199 PVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYPGIK 263

  Fly   241 WRKDV-PVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVN 304
            |..|. .|..:|||.|.||::|||||||||||:|.||||.|.|:.||||.:.|||||||.|||:|
Human   264 WTPDENGVITFDCRNRGWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFIN 328

  Fly   305 IFTFDKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRG 369
            |..::..|..:.|||:..|:||:..|....|..:|....|.:.....||.:||::|::.:.:.:|
Human   329 IIAYNDYVHYIEPCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQG 393

  Fly   370 AQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVH 434
            :.||||||:|.|||.|:...|||.:||   |...|||||||||:||:..|.::|:||.|:|||..
Human   394 SLCNQAIMLISDGAVEDYEPVFEKYNW---PDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQ 455

  Fly   435 LSDTAEVREMVLNYIPVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEY 499
            :|..|:.:|.|:.|:.|::||:|: .|||.:||::.|.   |:||..          .:|..|
Human   456 ISTLADTQENVMEYLHVLSRPMVI-NHDHDIIWTEAYM---DSKLLS----------SQAQSL-- 504

  Fly   500 WQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKI 564
                                              ..:|||:||::.::..
Human   505 ----------------------------------TLLTTVAMPVFSKKNE--------------- 520

  Fly   565 NLQVTRIANI-LGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIF-QGYILK 627
                ||...| |||.|:||.:.|:.||...:.|||:||||:.|||||:|.|||.||:: :|..||
Human   521 ----TRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLK 581

  Fly   628 PA--YNSVDMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWMLVKNHFDEMKRVARVKRQY 690
            |.  |||||:.|||..|...          ::|.::||:.||:..|.||...|:.|||..:...|
Human   582 PKPNYNSVDLSEVEWEDQAE----------SLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDY 636

  Fly   691 YWTAIKKTPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSVFSGKRWKIHP------DWL 749
            ::|.|..|||:|.:.....:|            ..|.:..|   ||..|....:||      ||:
Human   637 FFTDISDTPFSLGVVLSRGHG------------EYILLGNT---SVEEGLHDLLHPDLALAGDWI 686

  Fly   750 FCKHSNRTFKTPEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYY 814
            :|    .|...|:...|..||.|.                        ...|.:.|.:.
Human   687 YC----ITDIDPDHRKLSQLEAMI------------------------RFLTRKDPDLE------ 717

  Fly   815 CDRQLMQALVFDARVTGWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQ-RFGVTVAFLAT 878
            ||.:|::.::|||.||                    :|:......|..|..:: ...|.:|||.|
Human   718 CDEELVREVLFDAVVT--------------------APMEAYWTALALNMSEESEHVVDMAFLGT 762

  Fly   879 HSGLTRWHEFHSNAAEESGVGETF----SQNNTRAIDE--IWYKRAVDQHFVREESFVYSV---- 933
            .:||.|...|   ...|......|    .:.:...:|.  :||::| .:|  ...|||:::
Human   763 RAGLLRSSLF---VGSEKVSDRKFLTPEDEASVFTLDRFPLWYRQA-SEH--PAGSFVFNLRWAE 821

  Fly   934 -PFDAGESNSEILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLFHNITGNACAVD------- 990
             |..|||   .::||||.||......:||.||..|.|.:...|.:.|...|.....||
Human   822 GPESAGE---PMVVTASTAVAVTVDKRTAIAAAAGVQMKLEFLQRKFWAATRQCSTVDGPCTQSC 883

  Fly   991 ---DKDCYILDNNGYVIISTRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDN 1052
               |.||:::||||:::||.|..|||||.|||:||::.:||...|:.|||:|||||:|..|.:.:
Human   884 EDSDLDCFVIDNNGFILISKRSRETGRFLGEVDGAVLTQLLSMGVFSQVTMYDYQAMCKPSSHHH 948

  Fly  1053 NASSMLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHA 1117
            :|:..|:||:...|...:|||...:.:   ||:|:  |...:.|...::...         .||:
Human   949 SAAQPLVSPISAFLTATRWLLQELVLF---LLEWS--VWGSWYDRGAEAKSV---------FHHS 999

  Fly  1118 RNGNGHGKKDDDHWLRYLTLHRTRLKPCDMKRDLYTLF------NEKDNVVYNMTAHACERPFVV 1176
            ..   |.|:|.             |:|||.:   |.:|      .|.:.:|   ....|::.|||
Human  1000 HK---HKKQDP-------------LQPCDTE---YPVFVYQPAIREANGIV---ECGPCQKVFVV 1042

  Fly  1177 LPIPFSNLILLVIDQLCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHAN 1241
            ..||.|||:|||.|..|  |.|:...|..:..:  :..|.|:.|.:...:..|.||.||.:.|..
Human  1043 QQIPNSNLLLLVTDPTC--DCSIFPPVLQEATE--VKYNASVKCDRMRSQKLRRRPDSCHAFHPE 1103

  Fly  1242 ESGIKLCGKACSVYANLGLLLL 1263
            |:. :.||.|....|:..||||
Human  1104 ENA-QDCGGASDTSASPPLLLL 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:462464	48/137 (35%)
		vWA_VGCC_like	253..439	CDD:238740	92/185 (50%)
		dCache_1	<528..624	CDD:460673	35/97 (36%)
		PDC2_MCP_like	586..708	CDD:350337	53/124 (43%)
		VGCC_alpha2	870..>1084	CDD:462488	81/234 (35%)
CACNA2D4	NP_758952.4	VWA_N	148..264	CDD:462464	48/137 (35%)
		vWA_VGCC_like	277..460	CDD:238740	92/185 (50%)
		MIDAS-like motif	297..301		2/3 (67%)
		HK_sensor	<484..537	CDD:365792	22/120 (18%)
		HK_sensor	539..654	CDD:365792	53/124 (43%)
		VGCC_alpha2	661..1110	CDD:462488	154/555 (28%)