Protein Alignment stj and CACNA2D2

DIOPT Version :10

• Sequence 1: NP_001246303.1
• Gene: stj / 36526
• FlyBaseID: FBgn0261041
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_011532545.1
• Gene: CACNA2D2 / 9254
• HGNCID: 1400
• Length: 1151
• Species: Homo sapiens
• Alignment Length: 1328
• Identity: 343/1328 - (25%)
• Similarity: 565/1328 - (42%)
• Gaps: 318/1328 - (23%)

  Fly    17 LSVLVCLAPCVNLQPAENINYNLVHS---WADKLGMELFHLGDFITRRKEVQESFKDAK----VV 74
            |.:|:.|.|.:....|...::...|:   ||.:|..|:..:.......::::|.:||.:    |.
Human    44 LWLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQ 108

  Fly    75 SRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSH--QNDMADKMFSYYSAKEMLEPGDP 137
            ......:|:.:|.:||.::|.||.|::|:.|.|||...:|  |:::.::...||.||...|..||
Human   109 ENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDP 173

  Fly   138 VPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPVNVFDRAPDVIKAIQ 202
                  .:.|:::......:    ::..:|. |.|.| .||:|.::|.:|.:::..:..::..:.
Human   174 ------ESEDVERGSKASTL----RLDFIED-PNFKN-KVNYSYAAVQIPTDIYKGSTVILNELN 226

  Fly   203 WSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAATSPKD 267
            |:|.|:.:|.:|.:.||||.||.|||:||..|.:||:.||....:||||.|.|.||::.|:||||
Human   227 WTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKD 291

  Fly   268 IVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANLGNIR 332
            :||::|.|||:.|..|.:.|..|..:||||..:|:||:.:|:::..| |.||.. |:|||:.|.:
Human   292 MVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQP-VSCFTH-LVQANVRNKK 354

  Fly   333 ELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWR 397
            ..||.::....|....|.|....||:.|:.:.::.  |.||:.||:..||..:..::|||.:||
Human   355 VFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR--ANCNKMIMMFTDGGEDRVQDVFEKYNW- 416

  Fly   398 DPPYKPVRVFTYLIGKEVANWD--DIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVL-G 459
              |.:.|||||:.:|:.  |:|  .::||||.|:|||..:.....:|.....|:.|:.||:|| |
Human   417 --PNRTVRVFTFSVGQH--NYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAG 477

  Fly   460 RHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETW 524
            :....|.|:.||.|.....|
Human   478 KEAKQVQWTNVYEDALGLGL--------------------------------------------- 497

  Fly   525 NQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRIANILGVAGTDVPINEIKK 589
                       :.|.::|::        |||.| .|..|.| |:     ||||.|.||.:|:||:
Human   498 -----------VVTGTLPVF--------NLTQD-GPGEKKN-QL-----ILGVMGIDVALNDIKR 536

  Fly   590 LLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDFNPVL 654
            |...:|||.|||.|.:..|||||.||:.:|....: .:|.  ::|.::.||.|:::.
Human   537 LTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNF-REPV--TLDFLDAELEDENKE-------- 590

  Fly   655 MTIRDSIINQSTGSKWM--LVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGVSHMDI 717
             .||.|:|:.:.|.|.:  |||: .|| :.:..|.|.|.|..|:.|.::|.:..| .|...::..
Human   591 -EIRRSMIDGNKGHKQIRTLVKS-LDE-RYIDEVTRNYTWVPIRSTNYSLGLVLP-PYSTFYLQA 651

  Fly   718 RADQEIHRISIKGTNLRS--------------VFSGKRWKIHPDWLFCKHSNRTFKTPEIELLYF 768
            ....:|.::.:..:.|:.              ||...|       .:||..|.:....|. |..|
Human   652 NLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPR-------EYCKDLNASDNNTEF-LKNF 708

  Fly   769 LERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYYCDRQLMQALVFDARVTGWF 833
            :|.|.:           :.|                      :|..|:..|:..|:.|..:|
Human   709 IELMEK-----------VTP----------------------DSKQCNNFLLHNLILDTGIT--- 737

  Fly   834 SNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWHEFHSNAAEESGV 898
                                ..|:..:.|::....:.:...|.||..|:||  .|.:.|||:
Human   738 --------------------QQLVERVWRDQDLNTYSLLAVFAATDGGITR--VFPNKAAED--- 777

  Fly   899 GETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPF-DA-----GESNSEILVTASHAVFHNEG 957
                ...|....:..:|:|::|.|     .:|:..|. ||     ...|..:.:..|.||..:.|
Human   778 ----WTENPEPFNASFYRRSLDNH-----GYVFKPPHQDALLRPLELENDTVGILVSTAVELSLG 833

  Fly   958 GKTAPAAVVGFQFQHSALYKLFHNITGNA-------------------CAVDDKD--CYILDNNG 1001
            .:|...||||.:....|..:.|..:..|.                   |.|:::|  |.::|:.|
Human   834 RRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKQCGPNSHCEMDCEVNNEDLLCVLIDDGG 898

  Fly  1002 YVIISTRVH---ETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASS---MLLS 1060
            ::::|.:.|   :.||||.||:..:|..|...:.|.:...|||||.|......|..::   :.:.
Human   899 FLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVP 963

  Fly  1061 PLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGNGHGK 1125
            .:...|.:. |....|.|.:.|.|.        |..:|......:|...|..|:
Human   964 TVADFLNLA-WWTSAAAWSLFQQLL--------YGLIYHSWFQADPAEAEGSPE----------- 1008

  Fly  1126 KDDDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYN--MTAHACERPFVVLPIPFSNLILLV 1188
                          ||...|.||:..|  :....|..||  :....|.|.|....:..:||:.:|
Human  1009 --------------TRESSCVMKQTQY--YFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVV 1057

  Fly  1189 IDQ-LCPR-------------DGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRH 1239
            .:: ||.:             ||       |:            .|....|...|..||.|...:
Human  1058 AEKPLCSQCEAGRLLQKETHSDG-------PE------------QCELVQRPRYRRGPHICFDYN 1103

  Fly  1240 ANESGIKLCGKACSVYANLGLLLLCHIL 1267
            |.|. ...||:..|...:||:|:...:|
Human  1104 ATED-TSDCGRGASFPPSLGVLVSLQLL 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:462464	41/135 (30%)
		vWA_VGCC_like	253..439	CDD:238740	73/187 (39%)
		dCache_1	<528..624	CDD:460673	36/95 (38%)
		PDC2_MCP_like	586..708	CDD:350337	41/123 (33%)
		VGCC_alpha2	870..>1084	CDD:462488	61/246 (25%)
CACNA2D2	XP_011532545.1	VWA_N	141..265	CDD:462464	41/135 (30%)
		vWA_VGCC_like	277..456	CDD:238740	73/187 (39%)
		HK_sensor	<448..531	CDD:365792	33/153 (22%)
		HK_sensor	533..642	CDD:365792	41/122 (34%)
		VGCC_alpha2	669..1112	CDD:462488	115/576 (20%)