DRSC/TRiP Functional Genomics Resources

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Protein Alignment stj and CACNA2D2

DIOPT Version :9

Sequence 1:NP_001246303.1 Gene:stj / 36526 FlyBaseID:FBgn0261041 Length:1271 Species:Drosophila melanogaster
Sequence 2:XP_011532545.1 Gene:CACNA2D2 / 9254 HGNCID:1400 Length:1151 Species:Homo sapiens


Alignment Length:1328 Identity:343/1328 - (25%)
Similarity:565/1328 - (42%) Gaps:318/1328 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LSVLVCLAPCVNLQPAENINYNLVHS---WADKLGMELFHLGDFITRRKEVQESFKDAK----VV 74
            |.:|:.|.|.:....|...::...|:   ||.:|..|:..:.......::::|.:||.:    |.
Human    44 LWLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQ 108

  Fly    75 SRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSH--QNDMADKMFSYYSAKEMLEPGDP 137
            ......:|:.:|.:||.::|.||.|::|:.|.|||...:|  |:::.::...||.||...|..||
Human   109 ENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDP 173

  Fly   138 VPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPVNVFDRAPDVIKAIQ 202
                  .:.|:::......:    ::..:|. |.|.| .||:|.::|.:|.:::..:..::..:.
Human   174 ------ESEDVERGSKASTL----RLDFIED-PNFKN-KVNYSYAAVQIPTDIYKGSTVILNELN 226

  Fly   203 WSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAATSPKD 267
            |:|.|:.:|.:|.:.||||.||.|||:||..|.:||:.||....:||||.|.|.||::.|:||||
Human   227 WTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKD 291

  Fly   268 IVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANLGNIR 332
            :||::|.|||:.|..|.:.|..|..:||||..:|:||:.:|:::..| |.||.. |:|||:.|.:
Human   292 MVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQP-VSCFTH-LVQANVRNKK 354

  Fly   333 ELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWR 397
            ..||.::....|....|.|....||:.|:.:.::.  |.||:.||:..||..:..::|||.:|| 
Human   355 VFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR--ANCNKMIMMFTDGGEDRVQDVFEKYNW- 416

  Fly   398 DPPYKPVRVFTYLIGKEVANWD--DIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVL-G 459
              |.:.|||||:.:|:.  |:|  .::||||.|:|||..:.....:|.....|:.|:.||:|| |
Human   417 --PNRTVRVFTFSVGQH--NYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAG 477

  Fly   460 RHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETW 524
            :....|.|:.||.|.....|                                             
Human   478 KEAKQVQWTNVYEDALGLGL--------------------------------------------- 497

  Fly   525 NQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRIANILGVAGTDVPINEIKK 589
                       :.|.::|::        |||.| .|..|.| |:     ||||.|.||.:|:||:
Human   498 -----------VVTGTLPVF--------NLTQD-GPGEKKN-QL-----ILGVMGIDVALNDIKR 536

  Fly   590 LLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDFNPVL 654
            |...:|||.|||.|.:..|||||.||:.:|....: .:|.  ::|.::.||.|:::.        
Human   537 LTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNF-REPV--TLDFLDAELEDENKE-------- 590

  Fly   655 MTIRDSIINQSTGSKWM--LVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGVSHMDI 717
             .||.|:|:.:.|.|.:  |||: .|| :.:..|.|.|.|..|:.|.::|.:..| .|...::..
Human   591 -EIRRSMIDGNKGHKQIRTLVKS-LDE-RYIDEVTRNYTWVPIRSTNYSLGLVLP-PYSTFYLQA 651

  Fly   718 RADQEIHRISIKGTNLRS--------------VFSGKRWKIHPDWLFCKHSNRTFKTPEIELLYF 768
            ....:|.::.:..:.|:.              ||...|       .:||..|.:....|. |..|
Human   652 NLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPR-------EYCKDLNASDNNTEF-LKNF 708

  Fly   769 LERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYYCDRQLMQALVFDARVTGWF 833
            :|.|.:           :.|                      :|..|:..|:..|:.|..:|   
Human   709 IELMEK-----------VTP----------------------DSKQCNNFLLHNLILDTGIT--- 737

  Fly   834 SNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWHEFHSNAAEESGV 898
                                ..|:..:.|::....:.:...|.||..|:||  .|.:.|||:   
Human   738 --------------------QQLVERVWRDQDLNTYSLLAVFAATDGGITR--VFPNKAAED--- 777

  Fly   899 GETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPF-DA-----GESNSEILVTASHAVFHNEG 957
                ...|....:..:|:|::|.|     .:|:..|. ||     ...|..:.:..|.||..:.|
Human   778 ----WTENPEPFNASFYRRSLDNH-----GYVFKPPHQDALLRPLELENDTVGILVSTAVELSLG 833

  Fly   958 GKTAPAAVVGFQFQHSALYKLFHNITGNA-------------------CAVDDKD--CYILDNNG 1001
            .:|...||||.:....|..:.|..:..|.                   |.|:::|  |.::|:.|
Human   834 RRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKQCGPNSHCEMDCEVNNEDLLCVLIDDGG 898

  Fly  1002 YVIISTRVH---ETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASS---MLLS 1060
            ::::|.:.|   :.||||.||:..:|..|...:.|.:...|||||.|......|..::   :.:.
Human   899 FLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVP 963

  Fly  1061 PLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGNGHGK 1125
            .:...|.:. |....|.|.:.|.|.        |..:|......:|...|..|:           
Human   964 TVADFLNLA-WWTSAAAWSLFQQLL--------YGLIYHSWFQADPAEAEGSPE----------- 1008

  Fly  1126 KDDDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYN--MTAHACERPFVVLPIPFSNLILLV 1188
                          ||...|.||:..|  :....|..||  :....|.|.|....:..:||:.:|
Human  1009 --------------TRESSCVMKQTQY--YFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVV 1057

  Fly  1189 IDQ-LCPR-------------DGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRH 1239
            .:: ||.:             ||       |:            .|....|...|..||.|...:
Human  1058 AEKPLCSQCEAGRLLQKETHSDG-------PE------------QCELVQRPRYRRGPHICFDYN 1103

  Fly  1240 ANESGIKLCGKACSVYANLGLLLLCHIL 1267
            |.|. ...||:..|...:||:|:...:|
Human  1104 ATED-TSDCGRGASFPPSLGVLVSLQLL 1130

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stjNP_001246303.1 VWA_N 107..241 CDD:285584 41/135 (30%)
vWA_VGCC_like 253..439 CDD:238740 73/187 (39%)
Cache_1 524..619 CDD:280839 35/94 (37%)
CACNA2D2XP_011532545.1 VWA_N 141..265 CDD:285584 41/135 (30%)
vWA_VGCC_like 277..456 CDD:238740 73/187 (39%)
Cache_1 485..573 CDD:280839 41/159 (26%)
VGCC_alpha2 580..663 CDD:285647 24/94 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142054
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2353
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X365
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.840

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