DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stj and cacna2d2b

DIOPT Version :9

Sequence 1:	NP_001246303.1	Gene:	stj / 36526	FlyBaseID:	FBgn0261041	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_009294385.1	Gene:	cacna2d2b / 568759	ZFINID:	ZDB-GENE-060503-99	Length:	1090	Species:	Danio rerio

Alignment Length:	1338	Identity:	343/1338 - (25%)
Similarity:	570/1338 - (42%)	Gaps:	330/1338 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WWRLCLGLLSVLVCLA---PCVNLQPAENINYNLVHSWADKLGMELFHLGDFITRRKEVQ----E 66
            |...|| ||.::|.|.   ..||...... :|.::| ||.::..|:..:...|:..::::    |
Zfish     4 WAHACL-LLLLMVILGGSWTAVNALTFPQ-HYTIMH-WARRIEQEIDRVLQHISGAQQLKGIYLE 65

  Fly    67 SFKDAKVVSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSH--QNDMADKMFSYYSAK 129
            ..|...:|..|...||:.:|.:||.::..|..|:.|:...||.....|  |:.:.::...||::|
Zfish    66 KKKHFSLVRNNPRDIVEKVATDIERLLAKKRKALERLASEAERLQKEHRWQDGIKEENIEYYNSK 130

  Fly   130 -EMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPVNVFDR 193
             ||...|:          |:|..:...|.:|..        |.|.| .||:|.::|.:|.:::..
Zfish   131 AEMDYDGE----------DIDSQMSLKLDFVYD--------PSFKN-QVNYSHTAVQIPTDIYKG 176

  Fly   194 APDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWY 258
            ||.::..:.|::.|:::|.:|.::||:|.||.|||:||..|.:||:.||....:||||.|.|.||
Zfish   177 APVILNELNWTQALERVFIENSRDDPSLLWQAFGSATGVTRYYPAAPWRAPDKIDLYDVRRRPWY 241

  Fly   259 MEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTL 323
            ::.|:||||:|||:|.|||:.|..|.:.|..|..:||||..:|:||:..|:::...||||| |.|
Zfish   242 IQGASSPKDMVILVDVSGSVSGLTLKLIKASVTEMLDTLSDDDYVNVARFNEKAEAVVPCF-DHL 305

  Fly   324 IQANLGNIRELKEGIELFRPKSIANYTAALTKAF-ELLEETKLSSRGAQCNQAIMIIGDGAPENN 387
            :|||:.|.:..||.::..:.|...:|.:....|| :||.:|.:..  |.||:.||:..||..:..
Zfish   306 VQANVRNKKIFKEAVQQMQAKGTTDYKSGFHFAFNQLLNKTNVPR--ANCNKIIMLFTDGGEDRA 368

  Fly   388 REVFELHNWRDPPYKPVRVFTYLIGKEVANWD--DIRWMACENQGYYVHLSDTAEVREMVLNYIP 450
            :::||.:||   |.|.|||||:.:|:.  |:|  .::|:||.|:|||..:.....:|.....|:.
Zfish   369 QDIFEQYNW---PNKTVRVFTFSVGQH--NYDVTPLQWIACSNKGYYFEIRSICAIRINTQEYLD 428

  Fly   451 VMARPLVL-GRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHR 514
            |:.||:|| ||....|.|:.||.|.....|
Zfish   429 VLGRPMVLAGRIAKQVQWTNVYQDALGLGL----------------------------------- 458

  Fly   515 RKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRIANILGVAG 579
                                 :.|.:||::        |||  :|..::..|       ||||.|
Zfish   459 ---------------------VVTGTMPVF--------NLT--VNGDSQNQL-------ILGVMG 485

  Fly   580 TDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDD 644
            .||.::|:|:|...:.||.|||.|.:..|||||.||:.:|..:..   |...::|.::.|:.|..
Zfish   486 VDVHLDELKRLTPQYKLGANGYIFAIDPNGYVLMHPNLQPREEDL---PEQVTLDFLDAEVEDSS 547

  Fly   645 RPARDFNPVLMTIRDSIINQSTGSKWMLVKNHFDEM--KRVARVKRQYYWTAIKKTPFTLVI--- 704
            :         ..||..:|:..:|.  |.:|.....|  :.:..|.|.|.||.|..|.::|.:
Zfish   548 K---------QEIRRQMIDGRSGD--MTIKTLIKSMDERYIDDVTRMYTWTPINDTDYSLGLVLP 601

  Fly   705 SYPEQYGVSHMDIRADQEIHRISIKGTNLRSVF------SGKRWKIHPDW---LFCKHSNRTFKT 760
            .|.|.|      |:||  :..:.::...|:|:.      :|..:....|:   |....:|..|
Zfish   602 PYSEHY------IQAD--LSDVMLQLQYLQSLLPNSFESAGHVFLAPRDYCRRLHISENNTQF-- 656

  Fly   761 PEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYYCDRQLMQALVF 825
                |:.||..|.|           :.|                      ||..||:.|:..|:.
Zfish   657 ----LVDFLSLMVE-----------ISP----------------------ESEDCDQGLIHNLIL 684

  Fly   826 DARVTGWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWHEFHS 890
            |:.:. |......:.:| |.||                     :|....|.:|:.|:||   .:.
Zfish   685 DSGIL-WQLATRVWQNK-DLGT---------------------YGFLALFASTNGGVTR---VYP 723

  Fly   891 NAAEESGVGETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPFDAGESNSEILV--------- 946
            |.|.||.      ..:...::..:|:|::|     .:.:::..|  ...|..::|:
Zfish   724 NMAAESW------DEDPEPLNSNFYRRSLD-----NKGYIFRAP--TRTSMDDLLISENGTVGIL 775

  Fly   947 --TASHAVFHNEGGKTAPAAVVGFQFQHSALYKLFHNITGNA-------------------CAV- 989
              ||....|   |.||...||||.:....|....|..:..|.                   |.|
Zfish   776 VTTAVEVAF---GSKTMKPAVVGVKLDLEAWVDKFKILASNVSDSRQAAHKCGPSRSCEMDCEVN 837

  Fly   990 -DDKDCYILDNNGYVIIST-RVH--ETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKN 1050
             ||..||::|:.|::::|. |.|  :.|.|||||:..:|..|...::|.:...:.||:.|..:.:
Zfish   838 SDDLLCYLIDDGGFLVMSNQRDHWKKVGLFFGEVDPYLMFALYNNSIYSRHQTFQYQSACEPTAS 902

  Fly  1051 DNNASS---MLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHY--ADMYGDSNDTEPPPPE 1110
            .:..::   ..:..:...|.:. |....|.|.|:|...:....||.:  ||::.:|.|::
Zfish   903 SHTGAAHRGFYVPSIADFLSLA-WWTSAAAWSILQQFLYGVMYSSWFTTADVWAESADSK----- 961

  Fly  1111 PHPDHHARNGNGHGKKDDDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYNMTAHACERPFV 1175
                     |:.          ..:|::         .:..:|......||:.:  ...|.|.|.
Zfish   962 ---------GSS----------SCVTVY---------SQFYFTNTTNSFNVLQD--CGNCSRLFH 996

  Fly  1176 VLPIPFSNLILLVIDQL----CPRDGSVVLTVNPQ---PIDYHLSVNDSLACYKQAREFNRMRPH 1233
            ...|..:||:.:|.:.|    |..:..:.:....|   |.|...|     |.|::.       |.
Zfish   997 AKRIENTNLLFVVAETLPCSSCEIEKLLPVRTKSQEENPCDVLNS-----ARYRKG-------PD 1049

  Fly  1234 SCISRHANESGIKLCGKACSVYANLGLLLLCHILSRWL 1271
            .|.. :.:|.....||.|.|::..|..|||..:...:|
Zfish  1050 KCFD-YNSEENTSQCGSAHSLHCPLPALLLVQLFLIYL 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:285584	41/136 (30%)
		vWA_VGCC_like	253..439	CDD:238740	76/188 (40%)
		Cache_1	524..619	CDD:280839	31/94 (33%)
cacna2d2b	XP_009294385.1	Phage_portal	<33..65	CDD:302783	6/32 (19%)
		VWA_N	106..224	CDD:285584	41/136 (30%)
		vWA_VGCC_like	236..416	CDD:238740	76/187 (41%)
		Cache_1	446..525	CDD:280839	36/151 (24%)
		VGCC_alpha2	539..616	CDD:285647	23/95 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575004
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.840