DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stj and cacna2d4a

DIOPT Version :9

Sequence 1:	NP_001246303.1	Gene:	stj / 36526	FlyBaseID:	FBgn0261041	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_021330935.1	Gene:	cacna2d4a / 568225	ZFINID:	ZDB-GENE-041210-213	Length:	1105	Species:	Danio rerio

Alignment Length:	1318	Identity:	403/1318 - (30%)
Similarity:	622/1318 - (47%)	Gaps:	279/1318 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WSRLLAWWRLCLGLLSVLVCLAPCVNLQPAENINYNLVHSWADKLGMELFHLGDFITRRKEVQES 67
            |..|:...| .:.||.|| |.:..:..|....|:...|..||:..|.:|..|.:..:..:.:|:.
Zfish     2 WQGLMGRMR-SVTLLWVL-CSSWTIQTQAQMRISPETVQQWANNFGKQLMALSNRYSGAQLLQKK 64

  Fly    68 FKDAKVVSR----NGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSHQNDMADKMFSYYSA 128
            :|:.:.:.:    :|..:|...|:|:|.|:..|:.:|:|:.:|||:....|:.: |...|.||::
Zfish    65 YKEVEPIVKMEEIDGLKMVKEFAEEMENMLGRKMKSVKRMAETAEDADFYHEFN-ATLEFDYYNS 128

  Fly   129 ---KEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPVNV 190
               ..:.|.|:.:            ::|...        .||....|:|.|||...|.|.||.||
Zfish   129 MLINTLNEDGNNI------------ELGGEF--------PLEENEHFNNLPVNTQQSVVQVPTNV 173

  Fly   191 FDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDV-PVDLYDCRL 254
            :::.||::..:..||.|:.||..|::.||||:||:|||||||.|.:|..||..|. .|..:|.|.
Zfish   174 YNKDPDILNGVFMSEALNDIFISNFEKDPTLTWQYFGSSTGFFRLYPGIKWTPDENGVVTFDGRN 238

  Fly   255 RSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCF 319
            |:||::||||||||:|.:|.||||.|.||.||||.:||||||||.|||||:..:...|..|.|||
Zfish   239 RNWYIQAATSPKDIIIAVDISGSMKGLRLTIAKHTINTILDTLGENDFVNVIAYSDYVQYVEPCF 303

  Fly   320 EDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAIMIIGDGAP 384
            :.||:||:|.|....|..::..:.|.......|:.::|::|.|.....||:.||||||:|.|||.
Zfish   304 KGTLVQADLDNREHFKLLVQELQVKGEGKVKKAMKESFKILNEAAAEGRGSLCNQAIMLITDGAM 368

  Fly   385 ENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMVLNYI 449
            |:.::|||..||   |.:.|||||||||:|:....:::|:||.|:|||.|:|..|:|:|.|:.|:
Zfish   369 EDFQQVFEEFNW---PDRKVRVFTYLIGRELTFASNVKWIACNNKGYYTHISTLADVQENVMEYL 430

  Fly   450 PVMARPLVLGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHR 514
            .|::||:|: .|||.:||::.|.|                     .||.
Zfish   431 HVLSRPMVI-NHDHDIIWTEAYMD---------------------SVLP---------------- 457

  Fly   515 RKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRIANILGVAG 579
                ...|.:|...:|.:  .||:|:||::.::|..|.:                  ..:|||.|
Zfish   458 ----NTAELFNTQAESLL--LMTSVAMPVFSKKEETLSH------------------GILLGVVG 498

  Fly   580 TDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQ-GYILKPA--YNSVDMIEVELL 641
            ||||:.|:.:|...:.|||:||||:.|||||:|.|||.||::: |..|||.  |||||:.|||..
Zfish   499 TDVPLKELMRLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYKDGKKLKPKPNYNSVDLSEVEWE 563

  Fly   642 DDDRPARDFNPVLMTIRDSIINQSTGSKWMLVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISY 706
            |.:.          .:|.:::...||:..:.|:...::.|||..:|.:|::|.|.:|||:|.|..
Zfish   564 DTED----------ALRTAMVKGETGTISLDVRATVEKGKRVVFLKNEYFYTTINETPFSLGIVL 618

  Fly   707 PEQYG--VSHMDIRADQEIHRISIKGTNLRSVFSGKRWKIHPDWLFCKHSNRTFKTPEIELLYFL 769
            ...:|  |...::..::.:|.::....:           |..:|.:|:
Zfish   619 TNGHGKNVFIGNVSVEEGLHDLTASDVS-----------IAQEWTYCE----------------- 655

  Fly   770 ERMSEPGWRWPGSRSAMPPEH-------AAAMFSNNSSTGRYPSINEKESYYCDRQLMQALVFDA 827
                          :.:.|.|       |...:    .||:.|.:.      ||.:|:|..:|||
Zfish   656 --------------TDIDPHHRKLTQLQAVVRY----LTGKEPDLE------CDERLLQQTLFDA 696

  Fly   828 RVTGWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWHEFHSNA 892
            .||                    :|:......|..|......||..|||.|.|||.|...:   |
Zfish   697 VVT--------------------APMEAYWTALLLNASGIDGGVETAFLGTRSGLMRMIRY---A 738

  Fly   893 AEESGVGETF----SQNNTRAIDE--IWYKRAVDQHFVREESFVYSVPFDAGESNSEI---LVTA 948
            ..|..|.:.|    .:.|...:|.  :||:||.:....|   |:|.||   .|.||.:   .|.|
Zfish   739 GVEKRVAKKFLTASDKENIFTLDHFPVWYRRAAENPAGR---FLYYVP---TEDNSGVNGRFVIA 797

  Fly   949 SHAVFHNEGGKTAPAAVVGFQFQHSALYKLFHNITGNACAVD----------------DKDCYIL 997
            ...|..:...|||.|..:|.|.....|.|.|.:|.......|                |..||::
Zfish   798 VTPVTVSVSKKTAVAGAIGVQMSLEMLEKRFWSIANQPNDTDCSGIEGLCPLSCSDNPDISCYVI 862

  Fly   998 DNNGYVIISTRVHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASSMLLSPL 1062
            |:||::|||....:.|:|.|::.|::|.:||:..::::|.:|||||:|....:..:.:..||||.
Zfish   863 DSNGFIIISRDKADVGKFLGKIEGSVMSQLLKMGMFKRVVLYDYQAMCKAHAHSASGARPLLSPF 927

  Fly  1063 FHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGNGHGKKD 1127
            ::||...||.|...|:.::....:....|.|:.              |.....|:.:     ||
Zfish   928 YNLLAALKWFLSNFLFLLLDFNIYNLWHSDHFT--------------EAKTSFHSSS-----KK- 972

  Fly  1128 DDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYN---------MTAHACERPFVVLPIPFSN 1183
                     |....|:|||         .|..:.||.         :....|::.||:..||.||
Zfish   973 ---------LKGGFLQPCD---------TEYPSFVYEPSIKETNSLIKCGRCQKVFVIQQIPDSN 1019

  Fly  1184 LILLVI--DQLCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRPHSCISRHANESGIK 1246
            |:|:||  |..|.|....: |:.|:.:.|    |.|:.|.:...:..|.||.||.:.|..|:. |
Zfish  1020 LLLVVIQADCDCSRQYPPI-TMEPKEVKY----NASVKCDRMRSQKIRRRPESCHAYHPQENA-K 1078

  Fly  1247 LCGKACSVYANLGLLLLC 1264
            .||.|.::..::.|...|
Zfish  1079 DCGGAVAISLSIMLFFAC 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:285584	46/136 (34%)
		vWA_VGCC_like	253..439	CDD:238740	93/185 (50%)
		Cache_1	524..619	CDD:280839	35/94 (37%)
cacna2d4a	XP_021330935.1	VWA_N	114..224	CDD:312040	44/130 (34%)
		vWA_VGCC_like	237..420	CDD:238740	93/185 (50%)
		dCache_1	<472..576	CDD:308398	49/131 (37%)
		VGCC_alpha2	652..1032	CDD:312092	120/487 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4044
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm6553
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820