Protein Alignment stj and Cacna2d2

DIOPT Version :9

• Sequence 1: NP_001246303.1
• Gene: stj / 36526
• FlyBaseID: FBgn0261041
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_017168985.1
• Gene: Cacna2d2 / 56808
• MGIID: 1929813
• Length: 1160
• Species: Mus musculus
• Alignment Length: 1335
• Identity: 343/1335 - (25%)
• Similarity: 559/1335 - (41%)
• Gaps: 325/1335 - (24%)

  Fly    16 LLSVLVCLAPCVNLQPAENINYNLVHS---WADKLGMELFHLGDFITRRKEVQESFKDAK----V 73
            ||...:.|.|.:....|...::...|:   ||.:|..|:..:.......::::|.:||.:    |
Mouse    46 LLLPPLLLLPLLTAPGASAYSFPQQHTMQHWARRLEQEIDGVMRIFGGVQQLREIYKDNRNLFEV 110

  Fly    74 VSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSH--QNDMADKMFSYYSAKEMLEPGD 136
            .......:|:.:|.:||.::|.||.|::|:.|.|||...:|  |:::.::...||.||...|..|
Mouse   111 QENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDD 175

  Fly   137 PVPPIPTPAPDMD---KDIGEPLIYVQPKVVVLEPRPEFHNTPVNFSVSSVHVPVNVFDRAPDVI 198
            |      .:.||:   |.....|.:::.        |.|.| .||:|.::|.:|.:::..:..::
Mouse   176 P------ESEDMERGSKTSALRLDFIED--------PNFKN-KVNYSYTAVQIPTDIYKGSTVIL 225

  Fly   199 KAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAAT 263
            ..:.|:|.|:.:|.:|.:.||||.||.|||:||..|.:||:.||....:||||.|.|.||::.|:
Mouse   226 NELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGAS 290

  Fly   264 SPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANL 328
            ||||:||::|.|||:.|..|.:.|..|..:||||..:|:||:.:|:::..| |.||.. |:|||:
Mouse   291 SPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQP-VSCFTH-LVQANV 353

  Fly   329 GNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAIMIIGDGAPENNREVFEL 393
            .|.:..||.::....|....|.|....||:.|:.:.::.  |.||:.||:..||..:..::|||.
Mouse   354 RNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR--ANCNKMIMMFTDGGEDRVQDVFEK 416

  Fly   394 HNWRDPPYKPVRVFTYLIGKEVANWD--DIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPL 456
            :||   |.:.|||||:.:|:.  |:|  .::||||.|:|||..:.....:|.....|:.|:.||:
Mouse   417 YNW---PNRTVRVFTFSVGQH--NYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPM 476

  Fly   457 VL-GRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRM 520
            || |:....|.|:.||.|.....|
Mouse   477 VLAGKDAKQVQWTNVYEDALGLGL----------------------------------------- 500

  Fly   521 KETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAKINLQVTRIANILGVAGTDVPIN 585
                           :.|.::|::        |||.| .|..|.| |:     ||||.|.||.:|
Mouse   501 ---------------VVTGTLPVF--------NLTQD-GPGEKKN-QL-----ILGVMGIDVALN 535

  Fly   586 EIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRP-IFQGYILKPAYNSVDMIEVELLDDDRPARD 649
            :||:|...:|||.|||.|.:..|||||.||:.:| :.|....:... ::|.::.||.|:::.
Mouse   536 DIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQVSQTTNFREPV-TLDFLDAELEDENKE--- 596

  Fly   650 FNPVLMTIRDSIINQSTGSKWM--LVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGV 712
                  .||.|:|:...|.|.:  |||: .|| :.:..|.|.|.|..|:.|.::|.:..| .|..
Mouse   597 ------EIRRSMIDGDKGHKQIRTLVKS-LDE-RYIDEVIRNYTWVPIRSTNYSLGLVLP-PYST 652

  Fly   713 SHMDIRADQEIHRISIKGTNLRS--------------VFSGKRWKIHPDWLFCKHSNRTFKTPEI 763
            .::......:|.::.:..:.|:.              ||...|       .:||..|.:....|.
Mouse   653 YYLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPR-------EYCKDLNASDNNTEF 710

  Fly   764 ELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYYCDRQLMQALVFDAR 828
             |..|:|.|.:           :.|                      :|..|:..|:..|:.|..
Mouse   711 -LKNFIELMEK-----------VTP----------------------DSKQCNNFLLHNLILDTG 741

  Fly   829 VTGWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLATHSGLTRWHEFHSNAA 893
            :|                       ..|:..:.|::....:.:...|.||..|:||  .|.:.||
Mouse   742 IT-----------------------QQLVERVWRDQDLNTYSLLAVFAATDGGITR--VFPNKAA 781

  Fly   894 EESGVGETFSQNNTRAIDEIWYKRAVDQHFVREESFVYSVPFDAG------ESNSEILVTASHAV 952
            |:       ...|....:..:|:|::|.|     .:::..|....      ..|..:.|..|.||
Mouse   782 ED-------WTENPEPFNASFYRRSLDNH-----GYIFKPPHQDSLLRPLELENDTVGVLVSTAV 834

  Fly   953 FHNEGGKTAPAAVVGFQFQHSALYKLFHNITGNA-------------------CAVDDKD--CYI 996
            ..:.|.:|...||||.:....|..:.|..:..|.                   |.|:::|  |.:
Mouse   835 ELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVL 899

  Fly   997 LDNNGYVIISTRVH---ETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASS-- 1056
            :|:.|::::|.:.|   :.||||.||:..:|..|...:.|.:...|||||.|......|..::
Mouse   900 IDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPR 964

  Fly  1057 -MLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNG 1120
             :.:..:...|.:. |....|.|.:.|.|.        |..:|......:|...|..|:
Mouse   965 GVFVPTIADFLNLA-WWTSAAAWSLFQQLL--------YGLIYHSWFQADPAEAEGSPE------ 1014

  Fly  1121 NGHGKKDDDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYN--MTAHACERPFVVLPIPFSN 1183
                               ||...|.||:..|  :....|..||  :....|.|.|....:..:|
Mouse  1015 -------------------TRESSCVMKQTQY--YFGSVNASYNAIIDCGNCSRLFHAQRLTNTN 1058

  Fly  1184 LILLVIDQ----------------LCPRDGSVVLTVNPQPIDYHLSVNDSLACYKQAREFNRMRP 1232
            |:.:|.::                .||.||       |:            .|....|...|..|
Mouse  1059 LLFVVAEKPLCSQCEAGRLLQKETHCPADG-------PE------------QCELVQRPRYRRGP 1104

  Fly  1233 HSCISRHANESGIKLCGKACSVYANLGLLLLCHIL 1267
            |.|...:|.|. ...||:..|...:||:|:...:|
Mouse  1105 HICFDYNATED-TSDCGRGASFPPSLGVLVSLQLL 1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:285584	43/138 (31%)
		vWA_VGCC_like	253..439	CDD:238740	73/187 (39%)
		Cache_1	524..619	CDD:280839	35/94 (37%)
Cacna2d2	XP_017168985.1	VWA_N	144..268	CDD:369855	43/138 (31%)
		vWA_VGCC_like	280..459	CDD:238740	73/187 (39%)
		HK_sensor	536..648	CDD:365792	41/123 (33%)
		VGCC_alpha2	675..1120	CDD:369894	113/578 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832113
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840