DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stj and cacna2d1a

DIOPT Version :9

Sequence 1:	NP_001246303.1	Gene:	stj / 36526	FlyBaseID:	FBgn0261041	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_009298560.1	Gene:	cacna2d1a / 561434	ZFINID:	ZDB-GENE-041210-215	Length:	1093	Species:	Danio rerio

Alignment Length:	1298	Identity:	314/1298 - (24%)
Similarity:	552/1298 - (42%)	Gaps:	311/1298 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAWSRLLAWWRLCLGLLSVLVCLAPCVNLQPAENINYNLVHSWADKLGMELFHLGDFITRRKEVQ 65
            |:..|::...||...||.:|...:....:|..::.   |...||:|:..:|..|.|..:..||::
Zfish     1 MSVRRMMDALRLSTALLLLLSLCSFGSAIQFPDSF---LTRKWAEKMQEDLVQLIDSESGIKELK 62

  Fly    66 ESFKDAK----VVSRNGASIVDSMAKEIEMMMDLKVSAVRRIMDTAENTALSHQ--NDMADKMFS 124
            :.|.:.:    |...|...:|:..:.|||..:..:..|:..:...|||....||  .|:......
Zfish    63 KIFNNFQRHYTVRQNNPRQLVEKASHEIEEFLANRSKALEALATAAENLQKEHQWKEDLDVNETI 127

  Fly   125 YYSAKEMLEPGDPVPPIPTPAPDMDKDIGEPLIYVQPKVVVLEPR-----------PEFHNTPVN 178
            ||:||                   ||...:           .|||           |.| ..||:
Zfish   128 YYNAK-------------------DKSDNQ-----------TEPRKNRLILDFTEDPAF-KRPVS 161

  Fly   179 FSVSSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKW-- 241
            ::.::||:|.::::.:..::..:.|:..||.:||.|.::||:|.||.|||:||..|.||||.|
Zfish   162 YNTTAVHIPTDIYEGSTIILNELNWTAALDDVFRKNKEDDPSLHWQVFGSATGLARYFPASPWVD 226

  Fly   242 RKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIF 306
            .|: .:||||.|.|.||::.|.||||::||:|.|||:.|..|.:.:..|:.:|:||..:|:|||.
Zfish   227 SKN-KIDLYDVRRRPWYIQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETLSDDDYVNIV 290

  Fly   307 TFDKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAALTKAFELLEETKLSSRGAQ 371
            :|:.....|. |||: |:|||:.|.:.|||.::........:|.....:||..|....:|.  |.
Zfish   291 SFNNSAKSVA-CFEN-LVQANVRNKKTLKEAVQKITANGTTDYKIGFKEAFNQLASMNVSR--AN 351

  Fly   372 CNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVANWD--DIRWMACENQGYYVH 434
            ||:.||:..||..:...|:|:.:|    ..|.||:||:.:|:.  |:|  .|::|||.|:|||..
Zfish   352 CNKIIMLFTDGGEDKASEIFDEYN----SDKRVRIFTFSVGQH--NYDKAPIQYMACHNKGYYYE 410

  Fly   435 LSDTAEVREMVLNYIPVMARPLV-LGRHDHPVIWSQVYADIEDTKLSDYLWDINQCEYQKADVLE 498
            :.....:|.....|:.|:.||:| ..:....|.|:.||.|..:..|
Zfish   411 IPSIGAIRINTQEYLDVLGRPMVKADKKAKNVQWTNVYVDALELGL------------------- 456

  Fly   499 YWQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINPAAK 563
                                                 :.|.::|::::..      |:...|..|
Zfish   457 -------------------------------------VVTGTLPVFNKTR------TSKEKPKGK 478

  Fly   564 INLQVTRIANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNNGYVLFHPDFRPIFQGYILK- 627
             ||..:::  ||||...||.:::||:|...:|||.|||.|.:..|||||.||:.:|    ..||
Zfish   479 -NLGPSQM--ILGVMAIDVSLDDIKRLTPHYTLGPNGYYFAIDPNGYVLLHPNLQP----KDLKS 536

  Fly   628 --PAYNSVDMIEVELLDDDRPARDFNPVLMTIRDSIIN-QSTGSKWMLVKNHFDEMKRVARVKRQ 689
              |.  ::|.::.|:.|:         |.:.||.|:|: :.:..::..:....|| :.:.:..|.
Zfish   537 QEPV--TLDFLDAEMEDE---------VKVDIRRSMIDGERSQIRFHTLMKSQDE-RYIDKGFRT 589

  Fly   690 YYWTAIKKTPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSVFSGKRWKIHPDWLFCKHS 754
            |.|:.:....::|.:..|: |.:|:             ||.|...::...|.|
Zfish   590 YTWSPVTDADYSLALVLPD-YSMSY-------------IKATIGDTITQAKSW------------ 628

  Fly   755 NRTFKTPEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSST-------GRYPSINEKES 812
                   .:|.|...|.:....:...|.....|.::...:.:.|.:.       ..|..:.....
Zfish   629 -------ILENLAVSESLQVDKFEEYGYTLIAPRDYCEDLKAQNENMTQFLIDFNEYIDVKTPND 686

  Fly   813 YYCDRQLMQALVFDARVTGWFSNNTSFNSKDDKGTSASSPIAVLMGLLPRNEFKQRFGVTVAFLA 877
            ..|:..||..|:.||.:|.....:.:.|...|:                         :...|:|
Zfish   687 PQCNMDLMNRLLLDAGITAELVKHWNKNQLSDR-------------------------IKAKFVA 726

  Fly   878 THSGLTRWHEFHSNAAEESGVGETFSQNNTRAIDEIWYKRAVDQHFVREESFVYS-VPFDAGESN 941
            |..|:||.:. .|..:|.:|..||:..:        :|||::|     .:.:|:: :||...::.
Zfish   727 TDGGVTRVYP-ASAGSEWTGQAETYESS--------FYKRSLD-----NDLYVFTPLPFTGNKTE 777

  Fly   942 SEILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLFHNIT------GNACAV--DDK--DCYI 996
            ..:||:.:..:..:|  .....||||.:....:..:.|.|.|      |..|..  :|:  ||.:
Zfish   778 ESVLVSRAMDLRIDE--FWLKPAVVGVKLDVQSWMESFMNTTITPKCEGEICGCRRNDEYLDCVL 840

  Fly   997 LDNNGYVIISTR---VHETGRFFGEVNGAIMKRLLEENVYRQVTVYDYQAVC---FESKNDNNAS 1055
            ||:.|:::::.:   :.:.|.|||.::.::|:.|:..:::.....|||||:|   .|||......
Zfish   841 LDDGGFLVMANQDKYIDQIGEFFGMIDPSLMRNLMNVSLFSVNITYDYQALCEPTRESKAAAGLR 905

  Fly  1056 SMLLSPLFHLLRVGKWLLHTALWYIVQLLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNG 1120
            |:.:..:..:|.:| |....|.|.|:|.| :......::.:....|:::|.|..|
Zfish   906 SVYVPTIADILNIG-WWASAAAWSIMQQL-FVSITFPNFLEAVDISDESETPSKE---------- 958

  Fly  1121 NGHGKKDDDHWLRYLTLHRTRLKPCDMKRDLYTLFNEKDNVVYNMTAHA--CERPFVVLPIPFSN 1183
                                   .|..::..|  |.:.::..:..|...  |.|.|:...:..:|
Zfish   959 -----------------------SCIKEQTQY--FFDSNDTTFKGTVDCQNCSRQFIAEKLMKTN 998

  Fly  1184 LILLVID-----QLC------------PRDGSVVLTVNPQ----PID-YHLSVNDSLACYKQA 1224
            |:|:|.|     |:|            |.....:::.||:    |:: :..:|||...|.:.|
Zfish   999 LVLIVADTEMCSQMCEEKPFSQEEKPSPGPDPCLISQNPRYRKGPMECFDNNVNDEAMCRRNA 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:285584	43/146 (29%)
		vWA_VGCC_like	253..439	CDD:238740	69/187 (37%)
		Cache_1	524..619	CDD:280839	30/94 (32%)
cacna2d1a	XP_009298560.1	VWA_N	110..224	CDD:285584	41/144 (28%)
		vWFA	237..415	CDD:294047	69/187 (37%)
		Cache_1	444..532	CDD:280839	36/156 (23%)
		VGCC_alpha2	545..627	CDD:285647	19/105 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.840