DRSC/TRiP Functional Genomics Resources

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Protein Alignment stj and cacna2d2a

DIOPT Version :10

Sequence 1:NP_001246303.1 Gene:stj / 36526 FlyBaseID:FBgn0261041 Length:1271 Species:Drosophila melanogaster
Sequence 2:NP_001013521.4 Gene:cacna2d2a / 541376 ZFINID:ZDB-GENE-050320-71 Length:1109 Species:Danio rerio


Alignment Length:1291 Identity:326/1291 - (25%)
Similarity:558/1291 - (43%) Gaps:287/1291 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 NYNLVHSWADKLGMELFHLGDFITRRKEVQESFKDAK----VVSRNGASIVDSMAKEIEMMMDLK 96
            :|.::| ||.::..||..:...:|..::::..:.|.:    ||......:|:.:|.:|..:::.|
Zfish    37 HYTMMH-WAGRIEKELEKVLQLVTGGQQMRAIYNDKRNQFDVVRNTPKQLVEKVAGDIAKLLNRK 100

  Fly    97 VSAVRRIMDTAENTALSH--QNDMADKMFSYYSAKEMLEPGDPVPPIPTPAPDMDKDIGEPLIYV 159
            ..|:.|:...||:....|  |:.:.:....||.||             ..:..||.|.||.|: .
Zfish   101 RKALERLAREAEDIQREHSWQDAIKENDIQYYDAK-------------ADSDVMDDDDGENLL-D 151

  Fly   160 QPKVVVLE--PRPEFHNTPVNFSVSSVHVPVNVFDRAPDVIKAIQWSENLDQIFRDNYKNDPTLS 222
            .|..:.||  ..|.|.| .||:|.::|.:|.:::..:|.::..:.|:::|:::|.:|.:.||:|.
Zfish   152 NPNSLSLEFVDDPNFKN-KVNYSYTAVQIPTDIYKGSPTILNELNWTQSLERVFIENSREDPSLR 215

  Fly   223 WQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAATSPKDIVILMDGSGSMLGQRLDIAK 287
            ||.|||:||..|.:||:||:....:||||.|.|.||::.|:||||:||::|.|||:.|..|.:.|
Zfish   216 WQVFGSTTGVTRYYPATKWKAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMK 280

  Fly   288 HVVNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANLGNIRELKEGIELFRPKSIANYTAA 352
            ..|..:||||..:|:||:..|:::...||||| .||:|||:.|.:..||.:...:.|...:|...
Zfish   281 TSVIEMLDTLSDDDYVNVARFNEKAYAVVPCF-TTLVQANIKNKKIFKEAVMNMQAKGTTDYKTG 344

  Fly   353 LTKAF-ELLEETKLSSRGAQCNQAIMIIGDGAPENNREVFELHNWRDPPYKPVRVFTYLIGKEVA 416
            ...|| :||.:|  |:..|.||:.||:..||..:..:::||.:||   |.:.|||||:.:|:.  
Zfish   345 FQFAFDQLLNDT--SAPRANCNKMIMMFTDGGEDRAQDIFEKYNW---PNRTVRVFTFSVGQH-- 402

  Fly   417 NWD--DIRWMACENQGYYVHLSDTAEVREMVLNYIPVMARPLVL-GRHDHPVIWSQVYADIEDTK 478
            |:|  .::|:||.|:|||..:.....:|.....|:.|:.||:|| |.....|.|:.||.|.....
Zfish   403 NYDVTPLQWIACFNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGERAKQVQWTNVYQDALGLG 467

  Fly   479 LSDYLWDINQCEYQKADVLEYWQVHDRMLEPSEMHRRKYRRMKETWNQPVDSNVYQFMTTVSMPI 543
            |                                                        :.|.:||:
Zfish   468 L--------------------------------------------------------VITGTMPV 476

  Fly   544 YDRRENALINLTTDINPAAKINLQVTRIANILGVAGTDVPINEIKKLLSPFTLGVNGYAFIVTNN 608
            :        |||.|.:  .|.| |:     :|||.|.|:.:||||:|...:.||.|||.|.:..|
Zfish   477 F--------NLTADRD--TKQN-QL-----MLGVMGVDIALNEIKELTPRYKLGANGYTFAIDPN 525

  Fly   609 GYVLFHPDFRPIFQGYILKPAYNSVDMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWM-- 671
            ||||.||:.:|        ...|..:.:.::.||.:.|.|:..    .||..:|:...|.:.:  
Zfish   526 GYVLLHPNLQP--------KIINFREPVTLDFLDAELPDRNKE----EIRRQMIDGRGGQRKIKT 578

  Fly   672 LVKNHFDEMKRVARVKRQYYWTAIKKTPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSV 736
            |||: .|| :.:...:|.|.|:.::.|.::|.:..| .|..:|:......:|.::.. |::.:..
Zfish   579 LVKS-VDE-RYIDESQRTYIWSPVEGTDYSLGLVLP-SYSENHIRANLSDQILQVQY-GSDFKDF 639

  Fly   737 FSGKRWKIHPDWLFCKHSNRTFKTPEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSST 801
            .|     :.|:         ||::                   .|.....|.|:...:..:|::|
Zfish   640 ES-----LLPN---------TFES-------------------EGHVFIAPREYCKDLELSNNNT 671

  Fly   802 G---RYPSINEK---ESYYCDRQLMQALVFDARVTGWFSNNTSFNSKDDKGTSASSPIAVLMGLL 860
            .   .:.::.||   :|..||..|:..|:.|   ||                       ::..|:
Zfish   672 EFLLNFIALMEKVTPDSKQCDNFLLHNLILD---TG-----------------------IIKQLV 710

  Fly   861 PR----NEFKQRFGVTVAFLATHSGLTRWHEFHSNAAEESGVGETFSQNNTRAIDEIWYKRAVDQ 921
            .|    |:. ..:|....|.||..|:||  .|.:.||      ||: :.::...:..:|:|::| 
Zfish   711 DRVWKINDL-NTYGFLAVFAATDGGITR--VFPNKAA------ETW-EEDSEPFNASYYRRSLD- 764

  Fly   922 HFVREESFVYSVPFDAGE------SNSEILVTASHAVFHNEGGKTAPAAVVGFQFQHSALYKLFH 980
                .:.:::..|:....      .|..|.:..|.||....|.:....||||.:....|....|.
Zfish   765 ----NKGYIFRAPYRTANDDIINPENDTIGILVSTAVDITMGSRNLKPAVVGVKLDLEAWTDKFK 825

  Fly   981 NITGN----------------ACAV------DDKDCYILDNNGYVIISTRV---HETGRFFGEVN 1020
            .:..|                .|.:      ||..||::|:.|::|:|.:.   ::.|.||.||:
Zfish   826 ILASNHTDSNRLSSQTCGPTSGCEMDCEANSDDLLCYLIDDGGFLIMSNQKDHWYKIGMFFSEVD 890

  Fly  1021 GAIMKRLLEENVYRQVTVYDYQAVCFESKNDNNASS---MLLSPLFHLLRVGKWLLHTALWYIVQ 1082
            ..:...|...:.||:...:|||:||....:.|..::   :.:..:..:|.|. ||...|.|.::|
Zfish   891 PTLFYALYNNSFYRRKQSFDYQSVCDPVPSSNTGAAPRGVFVPTIADMLNVA-WLTSAAAWSLLQ 954

  Fly  1083 LLQWAPGVSSHYADMYGDSNDTEPPPPEPHPDHHARNGNGHGKKDDDHWLRYLTLHRTRLKPCDM 1147
            .:.:.....|.:..   |..|.|                |...|:..........:.:.:.    
Zfish   955 QMLYGFAYQSWFMT---DEVDAE----------------GFEYKETSCVTVQTQFYFSNIS---- 996

  Fly  1148 KRDLYTLFNEKDNVVYNMTAHACERPFVVLPIPFSNLILLVIDQL-CPRDGSVVLTVNPQPIDYH 1211
              ..|.:..:.||         |.|......|..:||:.:|.::| |  :...:..::....:| 
Zfish   997 --SSYNILQDCDN---------CSRLIHAKRINNTNLLFVVAERLSC--NSCEIEKLSQVETEY- 1047

  Fly  1212 LSVNDSLACYKQAREFNRMRPHSCISRHANESGIKLCGKACSVYANLGLLLLCHIL 1267
               .::.||...|....|....||......|: ...||:..|...:|..|||..:|
Zfish  1048 ---KETKACETIAAPRYRKGTTSCFDYSVLEN-TSDCGRGHSFRPSLYTLLLLQLL 1099

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stjNP_001246303.1 VWA_N 107..241 CDD:462464 43/137 (31%)
vWA_VGCC_like 253..439 CDD:238740 75/188 (40%)
dCache_1 <528..624 CDD:460673 34/95 (36%)
PDC2_MCP_like 586..708 CDD:350337 37/123 (30%)
VGCC_alpha2 870..>1084 CDD:462488 59/247 (24%)
cacna2d2aNP_001013521.4 None

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