DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stj and CG16868

DIOPT Version :9

Sequence 1:	NP_001246303.1	Gene:	stj / 36526	FlyBaseID:	FBgn0261041	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_611469.1	Gene:	CG16868 / 37298	FlyBaseID:	FBgn0034498	Length:	1449	Species:	Drosophila melanogaster

Alignment Length:	1065	Identity:	208/1065 - (19%)
Similarity:	385/1065 - (36%)	Gaps:	308/1065 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSVLVCLAPCVNLQPAENINYNLVHSWADKLGMELFHLGDFITRRKEVQESFKDAKVVSRNGASI 81
            ||..:..|..|.|:..|.:.|||...|......|    .|......:::...:|  :.:||.||.
  Fly   132 LSKKIQKATYVVLELRELLRYNLTKVWQYSYDDE----DDESESEMDLEMELED--LHARNTASP 190

  Fly    82 VDSMAKEIEMMMDLKVSAVRRIMDT-----AENTALSHQNDMADKMFSYYSAKEMLEPGDPVPPI 141
            .|   :.:::.::.::.:.:...:|     :.:|...|.|....::.:|..:.:
  Fly   191 TD---EHVQLYLNTQIESCQPDYETDLEYGSSSTQSIHYNRQQIQILNYLKSDD----------- 241

  Fly   142 PTPAPDMDKDIGEPLI---YVQPKVVVLE---PRPEFHNTPVNFSVSSVHVPVNVFDRAPDVIKA 200
             ..|..::::....|.   |:..::|:|:   .|.:..|:      :|..:..|.|       |.
  Fly   242 -ARATFLNENNARSLAVNGYISNQLVLLKRRLSRSDAENS------NSKPISGNHF-------KH 292

  Fly   201 IQWSENLDQIFRDNYKNDPTLSWQFFGSSTGFMRQFPASKWRKDVPVDLYDCRLRSWYMEAATSP 265
            |.:..|.|                  |:|...                    ..|..|: :|...
  Fly   293 IYFLSNSD------------------GASASL--------------------HFRQLYV-SAIKQ 318

  Fly   266 KDIVILMDGSGSMLGQRLDIAKHVVNTILDTLGTNDFVNIFTFDKEVSPVVPCFEDTLIQANLG- 329
            |.::.|:|...::..:..|::|..|:.:|..|...|.|::.|...|.:  ....|....:|..|
  Fly   319 KFVLFLIDVGSALSAELFDLSKSFVHEMLQLLEDTDKVSLVTVASEAN--FMSLEAFPAEAGHGI 381

  Fly   330 --NIRELKEGI-----ELFRPKSIANYTAALTKAFELLEETKLSSRGAQCNQAIMIIGDGAPENN 387
              ..|..||.|     .|.|.::..|::.....:||||.         :..|:.||       |.
  Fly   382 YSATRAHKEEIISFINSLSRAQAFTNHSLGFEYSFELLH---------RLQQSGMI-------NT 430

  Fly   388 REVFELHNWRDPPYKPVRVFTYLIGKEVANWDDIRWMACENQGYYVHLSDTAEVREMVLNYIPVM 452
            .|            :||. |.|:                 .:|...:|||...|..:|.:....:
  Fly   431 AE------------QPVE-FVYI-----------------TRGLLTNLSDAMAVLRVVADGQRRL 465

  Fly   453 ARPLVLGRHDHPVIWSQVYADIEDTKL----SDYLWDINQCEYQK--ADVLEYWQVHDRMLEPSE 511
            ..|:::          ...|.:.|.|.    ..:|.|:....|.|  .||..:|....   |.||
  Fly   466 RAPVII----------NTCAVVLDEKRIMYEKQFLNDVASQNYTKYEIDVASWWPSGQ---EASE 517

  Fly   512 MHRRKYRRMKETWNQPVDSNVYQFMTTVSMPIYDRRENALINLTTDINP------AAKINLQVTR 570
            :..|.|...|    ...::::.|..:.:..|::..|   .::.|.:::|      :..:.:.:|.
  Fly   518 LVGRFYVLSK----MHAETSLPQTSSRIFGPLFQER---YLSDTLEVHPPVVDADSGDVLVSITH 575

  Fly   571 IANILGVAGTDVPINE-IKKLLS-PFTL-----GVNGYAFIV-TNNGYVLFHPDF-RPIFQGYIL 626
            .....||.|.::.::: ::.||: |.|.     |: ||||:: .:.|..|.||.| ||:.|....
  Fly   576 AVPPYGVVGVNLYLSDLLEDLLNYPSTTSSAKQGL-GYAFLLDRSTGNTLAHPAFPRPLIQRETS 639

  Fly   627 KPAYNSVDMIEVELLDDDRPARDFNPVLMTIRDSIINQSTGSKWMLVKNHFDEMKRVARVKRQYY 691
            .|       :.:..|::   |.||:   ..|||.::.:.:|:...      |......|::|.||
  Fly   640 YP-------VNIAYLEN---ATDFS---SHIRDRLLREESGNVTT------DVYVGRQRLQRTYY 685

  Fly   692 WTAIKKTPFTLVISYPEQYGVSHMDIRADQEIHRISIKGTNLRSVFSGKRWKIHPDWLFCKHSNR 756
            |.::... :.|.:                     :|..|..||:|.|.:|:.:       |.:..
  Fly   686 WQSVLGF-YVLCL---------------------VSSGGDTLRNVSSTQRYNL-------KDTVS 721

  Fly   757 TFKT----PEIELLYFLERMSEPGWRWPGSRSAMPPEHAAAMFSNNSSTGRYPSINEKESYYCDR 817
            .::.    ..::|||....:::.|        :.||:  ...:....:|...|::
  Fly   722 NYEPGYYGESMDLLYHRLDLNQGG--------SAPPK--TCRYFRQVATMDAPTL---------- 766

  Fly   818 QLMQALVFDARVTGWFSNNTSFNS-----------KDDKGTSASSPIAVLMGLLP--RNEFKQRF 869
             .:.|..|::.. |:..||.....           :|..|..|:      |||.|  |:|....:
  Fly   767 -FLSAAAFESPF-GFLHNNRPRTQLRHVESIMAYLRDSSGLLAN------MGLRPSIRHEVGVLY 823

  Fly   870 GVTVAFLATHS---GLTRWHEFHSNAAEESGVGETF-------SQNNTRAIDEIWYKRAVDQHFV 924
            .........|.   |..|.|......|..|||.:.:       |.:.||   ..|:::|:.|
  Fly   824 QAMQQLRRRHQDARGSLRSHVIRRYIASVSGVLQLYPGCLLSSSYDPTR---RPWFRQAIAQ--- 882

  Fly   925 REESFVYSVPF-DAGESNSEILVTASHAVFHNEGGKTA--------PAAVVGFQFQHSALYKLFH 980
             ....|.:.|: |||  .:..::|.:|.:|  ||...|        |.|||.....::..|:|.
  Fly   883 -PGKIVSTAPYLDAG--GAGYIITIAHTIF--EGKAHALHSAQQDRPVAVVALDVPYAFYYRLI- 941

  Fly   981 NITGN-ACAVDDKDCYILDNNGYVI 1004
             :.|. .|.:....|.:.::.||::
  Fly   942 -LEGTPICQLPHIKCLLFEHEGYLL 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stj	NP_001246303.1	VWA_N	107..241	CDD:285584	20/139 (14%)
		vWA_VGCC_like	253..439	CDD:238740	42/193 (22%)
		Cache_1	524..619	CDD:280839	23/109 (21%)
CG16868	NP_611469.1	vWFA	308..>426	CDD:294047	30/129 (23%)
CG16868	NP_611469.1	Cache_1	559..627	CDD:280839	16/68 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439847
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2353
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840